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What is Delzicol
MesalazineThe Generic name of this drug
Treatment SummaryMesalazine is an anti-inflammatory drug used to treat and keep ulcerative colitis in remission. It is related to aspirin and other non-steroidal anti-inflammatory drugs. In the past, mesalazine was difficult to keep stable, but now there are formulations such as Asacol and Pentasa that have been designed to make it more stable. Mesalazine has also been studied for its potential to reduce the risk of colorectal cancer in conditions like ulcerative colitis.
Rowasais the brand name
Delzicol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rowasa
Mesalazine
1988
107
Approved as Treatment by the FDA
Mesalazine, otherwise called Rowasa, is approved by the FDA for 1 uses which include Crohn Disease .Crohn Disease
Effectiveness
How Delzicol Affects PatientsMesalazine is a component of sulphasalazine, and is the active part of the drug used to treat ulcerative colitis. It helps reduce inflammation by blocking the production of prostaglandins, leukotrienes and free radicals. Mesalazine is more effective when applied directly to the inflammation, rather than taken as a general medication. In experiments, it had similar effects to prednisolone and sulphasalazine in reducing inflammation in mice and guinea pigs.
How Delzicol works in the bodyMesalazine works to reduce inflammation in the colon. It does this by blocking the production of prostaglandins and leukotrienes, two molecules that are produced in large amounts when the body is suffering from inflammation. Mesalazine also works by blocking the activation of Nuclear Factor kappa B, which helps produce inflammatory cytokines, and by activating PPAR gamma receptors, which help reduce inflammation. Additionally, mesalazine has been shown to inhibit leukocyte chemotaxis, decrease cytokine and leukotriene production and scavenge for free radicals.
When to interrupt dosage
The dose of Delzicol is contingent upon the indicated condition. The amount of dosage fluctuates, contingent upon the technique of delivery outlined in the table below.Condition
Dosage
Administration
Proctitis
400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg
Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal
Proctosigmoiditis
400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg
Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal
moderate Ulcerative colitis
400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg
Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal
Ulcerative Colitis
400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg
Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal
Crohn Disease
400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg
Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal
Warnings
Delzicol ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Mesalazine may interact with Pulse Frequency
Common Delzicol Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Mesalazine.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Mesalazine.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mesalazine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Mesalazine is combined with Omacetaxine mepesuccinate.
Delzicol Toxicity & Overdose RiskTests on rats found that taking up to 1.7 times the recommended dose of mesalazine for humans did not cause any increase in cancer, and it was not found to be mutagenic in several tests. However, overdose symptoms can include nausea, vomiting, fast or heavy breathing, ringing in the ears, confusion, and headache. Severe intoxication may also cause an imbalance of electrolytes and blood pH, and can affect other organs such as the kidneys and liver. There is no specific antidote to mesalazine overdose, but treatment may involve decontaminating the digestive tract and providing intravenous therapy to correct fluid and electrolyte
Delzicol Novel Uses: Which Conditions Have a Clinical Trial Featuring Delzicol?
Currently, 96 active studies are assessing the potential of Delzicol to provide relief from Ulcerative Colitis.Condition
Clinical Trials
Trial Phases
Proctitis
1 Actively Recruiting
Phase 3
Crohn Disease
0 Actively Recruiting
moderate Ulcerative colitis
0 Actively Recruiting
Ulcerative Colitis
0 Actively Recruiting
Proctosigmoiditis
0 Actively Recruiting
Delzicol Reviews: What are patients saying about Delzicol?
5Patient Review
9/18/2013 I would not recommend this drug to anyone. It's been nothing but problems since I started taking it a few weeks ago.
5Patient Review
2/22/2014 I've been on Delzicol for about 10 months now. I feel that the Asacol worked better with no flareups. Recently, though, I've been having more lower back pains and anxiety-related issues with tingling and prickly skin. I never experienced this while taking Asacol. Has anyone else had similar side effects?
4.3Patient Review
9/6/2014 I developed muscle and joint pain a few months into taking this medication. It's quite uncomfortable, to the point where it's difficult to sleep. I'm hesitant to stop taking the medication because it does such a great job at managing my UC symptoms.
4.3Patient Review
6/11/2014 After being in the sun, I started experiencing some negative side effects. Has anyone else had this happen to them? I was on Asacol for 20 years and didn't have this problem.
4Patient Review
6/18/2015 The only downside is that you might feel bloated until your body gets used to the medicine.
4Patient Review
7/30/20133.7Patient Review
10/9/2015 After taking Asocol for years, doctor prescribed Delzicol. I discovered that inside the Delzicol capsule is the Asocol tablet. Spoke to pharmasist and he said that it is now delayed release. I wonder if this change in medication has really done anything???
3.7Patient Review
1/14/2016 At first, I felt dizzy and had some discomfort in my muscles and tendons. However, those effects went away after a short while. Now, I sometimes see very dark urine, which is concerning to me.
3.3Patient Review
4/30/2015 I've been having severe pains in my stomach/lower bowel for over 15 years. I had an endoscopy and sigmoidoscopy which showed that my colon was inflamed. The doctor prescribed this medication, but after taking it I feel very bloated. Is anyone else experiencing this side effect?
3Patient Review
10/22/2013 The new timing requirements are hard to follow. 2 hrs before a meal and 1 hr after you take the medication. That's 3 hrs of not eating...and thats hard for me to manage.
3Patient Review
7/27/20132.3Patient Review
10/12/2013 I have not been feeling well since I started taking this medication. I'll be discussing options with my doctor soon.
1Patient Review
9/16/2013 I have Ulcerative Colitis and took Asacol for 1 year until manufacturer recommended switching to this. These are a little harder to swallow, but they do seem to dissolve more thoroughly. I have not noticed any difference in therapy outcome. I take 8 tabs a day (3,3,2) and I would like to decrease, but even though symptoms have mostly relieved, my SED level is still elevated. Will continue on this. So far, no problems or concerns 3 months into it. Transitioned fine.
1Patient Review
9/26/2013 It was tough to keep track of when I needed to take this medicine at first, but now that I'm used to it, it's no problem.
Patient Q&A Section about delzicol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is DELZICOL the same as Asacol?
"These three medications work to lessen the inflammation caused by UC by containing the active ingredient mesalamine. By controlling the inflammation, the symptoms of UC can be more manageable."
Answered by AI
What is the difference between DELZICOL and mesalamine?
"DELZICOL is a medication used to treat mildly to moderately active ulcerative colitis. The active ingredient in DELZICOL is mesalamine, which is also known as 5-aminosalicylic acid or 5-ASA. Mesalamine is a common treatment for ulcerative colitis."
Answered by AI
What is DELZICOL used for?
"This medication is used to treat ulcerative colitis, a bowel disease that causes symptoms like diarrhea, rectal bleeding, and stomach pain. Mesalamine is an aminosalicylate, a class of drugs that work by decreasing swelling in the colon."
Answered by AI
How long does it take DELZICOL to work?
"This drug is called an aminosalicylate, which is also known as a 5-ASA. It helps to reduce the irritation and swelling (inflammation) in the lining of the intestines. If taken as prescribed, these drugs can work as quickly as 2 to 4 weeks."
Answered by AI