This trial is evaluating whether SPH3127 will improve 1 primary outcome, 4 secondary outcomes, and 2 other outcomes in patients with Colitis, Ulcerative. Measurement will happen over the course of Screening (baseline) to Day 56 (main study).
This trial requires 30 total participants across 3 different treatment groups
This trial involves 3 different treatments. SPH3127 is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"The predominant risk factors for development of UC and CD are age, gender, ethnicity and HLA class II alleles. A model based on a combination of specific HLA-DR/DQ alleles and environmental exposures has proven useful to predict the development of UC and CD. Identification of those patients requiring early diagnosis is of great importance in the course of both diseases. Findings from a recent study also indicate a role for certain foods, lifestyle factors and genetic factors." - Anonymous Online Contributor
"Colitis shares many general treatment options that are common to the treatment of inflammatory bowel disease overall. Therapies that focus on controlling inflammation or inducing healing may be effective in certain type of colitis. The treatment choices may be more complicated in individual patients because of the severity and progress of the disease. The therapeutic goals are more similar to colitis compared with Crohn's disease because of the tendency to mucosal ulceration, the rarity of fistulas, and the lack of stricturing disease. The treatment in colitis may be more complicated because of the presence of an immune defect." - Anonymous Online Contributor
"About 60% of cases of colitis can be cured, although the average remission length is short. If there is a medical cure, colitis can be suppressed in almost all patients." - Anonymous Online Contributor
"These can be divided into the following four categories:\n1. Signs that may indicate a condition other than colitis\n2. Indications of an underlying colitis\n3. Symptoms that are a sign of an underlying condition\n4. Symptoms that are the sign of an underlying condition\n\nThe pathogenesis of inflammatory bowel disease is not known, but this is believed to be a complication resulting from chronic, uncontrolled inflammation mediated by tissue damage (inflammation). It arises from a complex interaction of genetic, environmental, and nutritional factors. Inflammation is stimulated by a variety of factors, such as infections, food allergies, and toxins." - Anonymous Online Contributor
"Colitis describes inflammation of the colon. About 3 million Americans have colitis diagnosed and the disease is more frequent in females. The disease can begin with a set of warning symptoms and often requires surgical intervention to alleviate the severity of symptoms. If individuals are not taken and treated early, complications can occur and potentially cause a life-threatening condition called hemorrhagic colitis. Diagnosing colitis can be difficult especially where there are other more obvious signs that seem to be triggering the disorder." - Anonymous Online Contributor
"In 1990, 13 million adults and children had at least one episode of chronic abdominal disease. Approximately 11 million of these cases were colitis, but a significant proportion of these cases (30,000) were misdiagnosed as chronic diarrhea. Approximately 90% of colitis patients had the inflammatory form of the disorder. Most of these patients needed only supportive care (76.5% of colitis patients, vs. 18.7% for diarrhea only). An additional 12 million adults had at least one episode of nonspecific gastrointestinal disease. Most of these cases (71%, 63,000) were in a noninflammatory state, and thus were likely to have been misdiagnosed as GI infection, or even misdiagnosed gastroenteritis." - Anonymous Online Contributor
"Sph3127 can exert significant antiinflammatory effects, without affecting viability or function of intestinal epithelial cells in a mouse model of colitis. It is tempting to speculate that sph3127 may be of therapeutic value to treat inflammatory bowel disease." - Anonymous Online Contributor
"The present study was a preliminary study designed to evaluate the short term effectiveness of SPH3127 for the treatment of UC. Recent findings suggest that the combination of oral steroid and oral SPH3127 have a positive therapeutic effect in the treating UC as compared to the other treatments, but there are limitations in current data." - Anonymous Online Contributor
"About 2% of the study group complained of colitis symptoms when they were 10 years old, whereas 8.1% had UC symptoms when they were 45 years old, suggesting that colitis symptoms typically don't begin until someone is in their 30s--in other words, the typical age of onset of colitis is considerably later than the age of onset of UC, and the former may be more common--but the rate of onset of the two diseases is similar for all ages." - Anonymous Online Contributor
"Sph3127 appears to ameliorate colitis symptoms in most patients in clinical trials, with no apparent exacerbation of symptoms or side effects during the course of the trial." - Anonymous Online Contributor
"These data support the proposed role of Sph3127 as an antiinflammatory, and suggest that Sph3127 may be used in the management of inflammatory bowel disease." - Anonymous Online Contributor
"Colitis can be very intense disease, it can lead to serious conditions in an untreated patient. It is very important to tell the doctor or gastroenterologist every detail concerning the severity and severity as well as the course because they will provide the best care. In an untreated patient Colitis can be debilitating, with pain and diarrhea, which may result in vomiting, nausea, dehydration and electrolyte imbalance. This situation can lead to dehydration, electrolyte imbalance, anaemia of the bloodstream, which can lead to heart complications. In a few cases, the disease can lead to other serious conditions for example: liver damage and the development of colon cancer." - Anonymous Online Contributor