Indomethacin for Preventing Acute Pancreatitis After EUS-FNA
What You Need to Know Before You Apply
What is the purpose of this trial?
The aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing EUS-FNA of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during EUS-FNA.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is indomethacin safe for humans?
Indomethacin, a type of nonsteroidal anti-inflammatory drug (NSAID), can cause stomach and intestinal issues like bleeding and ulcers, especially when used in high doses or for a long time. Studies in animals have shown that it can lead to gastric and intestinal injuries, but certain protective drugs can help reduce these effects.12345
How does the drug indomethacin differ from other treatments for preventing acute pancreatitis after EUS-FNA?
Indomethacin is unique because it is a nonsteroidal anti-inflammatory drug (NSAID) that is administered rectally to help prevent pancreatitis, particularly after procedures like ERCP. This method of administration and its role in reducing inflammation make it different from other treatments that might not use NSAIDs or the rectal route.678910
What data supports the effectiveness of the drug Indomethacin for preventing acute pancreatitis after EUS-FNA?
Research shows that Indomethacin is effective in reducing the frequency and severity of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), a procedure similar to EUS-FNA, especially in high-risk patients. This suggests it may also help prevent pancreatitis after EUS-FNA.78111213
Who Is on the Research Team?
Ji Young Bang, MD MPH
Principal Investigator
Orlando Health, Digestive Health Institute
Are You a Good Fit for This Trial?
This trial is for adults over 18 with suspected or confirmed pancreatic cysts needing EUS-FNA. It's not for those with chronic pancreatitis, pregnant women, people allergic to Aspirin/NSAIDs, or those with renal failure.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of indomethacin or placebo administered rectally during EUS-FNA
Follow-up
Participants are monitored for safety and effectiveness after treatment, focusing on post-procedure pancreatitis and other adverse events
What Are the Treatments Tested in This Trial?
Interventions
- Indomethacin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Orlando Health, Inc.
Lead Sponsor