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Stem Cell Transplant for Sickle Cell Disease
Study Summary
This trial is testing a new transplant regime to see if it is effective, safe and well tolerated in people with sickle cell disease.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My kidney function test shows a filtration rate above 60 mL/min.I have a sibling donor who is a perfect match for me.My heart pumps blood effectively.I need help with my daily activities due to my health condition.I am 18 years old or older.I do not have any major illnesses that would make a stem cell transplant too risky.I have sickle cell disease and am at high risk for stroke or early death.
- Group 1: recipient
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there specific requirements to qualify for this research project?
"This study is seeking to enrol 98 patients that suffer from anemia and sickle cell between the ages of 2 and 80. To be eligible, potential participants must have experienced at least one episode of acute chest syndrome resulting in admission to intensive care requiring non-mechanical ventilatory support (i.e. simple nasal cannula, face mask that requires oxygen content [venti mask, non-rebreather], continuous positive airway pressure [CPAP], bilevel positive airway pressure [BiPAP], high flow nasal cannula [HFNC] or invasive mechanical ventilatory support delivered by endotr"
Do elderly patients qualify for this trial?
"As long as they are between the ages of 2 and 80, patients meet the age requirements for this trial."
Are there any current openings for this clinical research?
"This clinical trial is actively recruiting patients, as indicated on the listing on clinicaltrials.gov. The listing was first posted on April 6th, 2017 and was last edited on November 16th, 2022."
How many volunteers are taking part in this experiment?
"That is accurate, the clinical trial referenced is recruiting patients at this time. The listing was first posted on 4/6/2017 and updated as recently as 11/16/2022. They are enrolling 98 individuals total across 1 site."
Are there any other clinical trials that have used haploidentical stem cells in their research?
"Out of the 986 ongoing trials concerning haploidentical stem cell transplants, 178 have reached Phase 3. Most research surrounding this topic is based in San Antonio, Texas; however, there are 29372 locations running studies related to this treatment."
Can you please explain what haploidentical stem cell transplantation is typically used to treat?
"Haploidentical stem cell transplants are not only used to treat organ transplantation, but also multiple sclerosis, leukemia, myelocytic, acute, thrombocythemia, and essential."
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