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Veto Cell Therapy for Leukemia and Lymphoma
Study Summary
This trial is studying how well cytokine-treated veto cells work in treating patients with hematologic malignancies following stem cell transplant.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
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- I am able to care for myself but may not be able to do active work.I have an active brain or spinal cord tumor.I have a related donor aged 12-70 who is a partial genetic match.You must have a lung function test that shows your lungs are working at least 50% as well as expected for your age and gender.Your blood creatinine level is less than or equal to 1.5 mg/dl.Your SGPT blood test result is no higher than 200 IU/ml.Your bilirubin level is less than 1.5 mg/dl, unless you have Gilbert's syndrome.Your white blood cell count should be between 3.0 and 11.0 thousand per microliter.I do not have any active autoimmune diseases.Chest X-ray shows no signs of infection or cancer.My blood cancer has not improved with initial treatment but responded to the latest one.I have severe thalassemia or sickle cell disease with serious symptoms.Your platelet count is very high (more than 150,000 per microliter).I do not have any severe infections or health/mental conditions that could affect my treatment.My heart pumps at least 40% of its blood each time it beats.My hemoglobin levels meet the required criteria for my gender and condition.Your EKG does not show signs of uncontrolled heart problems.Your blood test does not show any signs of a blood disorder.I am mostly independent and can care for myself.You are not allergic to cytokines if they are going to be used in the study.Your blood pressure should not be too high. Your systolic blood pressure should be less than 170 mmHg, and your diastolic blood pressure should be less than 95 mmHg.My donor is between 12 and 70 years old and medically suitable.I am between 12 and 75 years old.I have been diagnosed with a specific type of blood cancer.I am HIV positive.Women who can have babies must have a negative pregnancy test.I have a family member who is a match for stem cell donation.I have a severe immune deficiency or a non-cancerous condition affecting my bone marrow.
- Group 1: Treatment (chemotherapy, PBSCT, cytokine-treated veto cells)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the desired outcome of this investigation?
"The primary endpoint of this study, evaluated within 42 days after the cytokine-treated veto cell infusion is to measure efficacy. Secondary endpoints are tracking adverse events, time to progression, and infections; all will be estimated using Kaplan and Meier's method with a Bayesian piecewise exponential survival regression for correlation analysis against prognostic covariates and dose level."
What health conditions do Cytokine-treated Veto Cells address?
"Cytokine-treated Veto Cells are a standard treatment for multiple sclerosis, but they can also assist lymphoma, leukemia, myelocytic, acute and retinoblastoma patients in their fight against cancer."
Does the trial encompass individuals under two decades of age?
"As indicated on the entry criteria, this medical trial is for individuals aged 12 to 75. Additionally, there are an abundance of clinical trials available for children and elderly patients – 1034 and 4115 respectively."
Is this experiment actively seeking out participants?
"According to the data on clinicaltrials.gov, this research project is presently accepting participants. It was initially launched on August 8th 2019 and most recently updated on September 30th 2022."
Am I eligible to join the medical experiment?
"Eligible applicants for this trial must be diagnosed with aplastic anemia and between the ages of 12 to 75. Currently, approximately 24 patients are being sought out."
What is the aggregate headcount of those participating in this clinical study?
"Affirmative. Clinicaltrials.gov shows that the medical trial is still enrolling, as it was initially published on August 8th 2019 and updated most recently on September 30th 2022. The plan requires 24 individuals to be recruited from one site."
Could you provide a synopsis of research conducted on Cytokine-treated Veto Cells?
"Presently, 889 clinical trials are investigating Cytokine-treated Veto Cells with 161 of them in their third phase. Although Philadelphia is the main hub for this research, 28443 medical centres have organized studies around it."
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