Ultrasound for Acute Chest Syndrome

(POCUS Trial)

Overseen By Anne Bubnick, BS

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Hemodynamically unstable, ACS diagnosis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 1 week

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

Feasibility and reliability of ultrasound in the inpatient hematology setting.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is point-of-care ultrasound safe for humans?

Point-of-care ultrasound (PoCUS) is widely used in emergency medicine and has been studied for various conditions, showing it is generally safe for humans. ^{1 2 3 4 5}

How does point-of-care ultrasound differ from other treatments for acute chest syndrome?

Point-of-care ultrasound (POCUS) is unique because it allows for rapid bedside imaging to assess and manage acute chest conditions, unlike traditional methods that may rely on more time-consuming imaging techniques. This approach can speed up diagnosis and treatment decisions, especially in emergency settings, making it a valuable tool for immediate care. ^{1 6 7 8 9}

What data supports the effectiveness of the treatment Point of Care Ultrasound for Acute Chest Syndrome?

Research shows that Point of Care Ultrasound (POCUS) can help quickly diagnose conditions related to chest pain and breathing problems, which may lead to faster treatment and potentially better outcomes. This suggests that POCUS could be effective in managing Acute Chest Syndrome by aiding in rapid diagnosis and treatment decisions. ^{1 3 6 10 11}

Who Is on the Research Team?

Seethal Jacob, MD

Principal Investigator

Indiana University

Are You a Good Fit for This Trial?

This clinical trial is open to individuals who have been diagnosed with conditions such as Acute Coronary Syndrome or Sickle Cell Disease, specifically those experiencing Acute Chest Syndrome. The study seems to focus on patients in a hospital setting under the care of a hematology team.

Inclusion Criteria

I have been diagnosed with sickle cell disease.

I was hospitalized for a sickle cell disease complication.

I am 25 years old or younger.

Exclusion Criteria

Patient is considered hemodynamically unstable to undergo consent and study procedures

POCUS operator not available

I was diagnosed with acute coronary syndrome before being admitted.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

Treatment

Participants undergo ultrasound on days 1, 3, and 5 of hospitalization to diagnose acute chest syndrome

1 week

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after ultrasound diagnosis

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Point of Care Ultrasound

Trial Overview The trial is testing the feasibility and reliability of using point-of-care ultrasound for patients with certain cardiovascular and blood disorders while they are admitted to the hospital.

How Is the Trial Designed?

Group I: Ultrasound Experimental Treatment 1 Intervention

Ultrasound days 1, 3, and 5 of hospitalization

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

Citations

1. Germany pubmed.ncbi.nlm.nih.gov

The effect of point-of-care ultrasound on length of stay and mortality in patients with chest pain/dyspnea. [2023]

2. Pakistan pubmed.ncbi.nlm.nih.gov

Effects of Point-of-care Ultrasonography on the Diagnostic Process of Patients Admitted to the Emergency Department with Chest Pain: A Randomised Controlled Trial. [2021]

3. Netherlands pubmed.ncbi.nlm.nih.gov

POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence. [2022]

4. Poland pubmed.ncbi.nlm.nih.gov

POCUS in cardiac arrest and its therapeutic implications - a case report. [2021]

5. Australia pubmed.ncbi.nlm.nih.gov

Update on echocardiography: do we still need a stethoscope? [2022]

6. Korea (South) pubmed.ncbi.nlm.nih.gov

The Use of Point-of-care Ultrasound in Emergency Medical Centers in Korea: a National Cross-sectional Survey. [2021]

7. United States pubmed.ncbi.nlm.nih.gov

Point of care prehospital ultrasound in Basic Emergency Services in Portugal. [2022]

8. England pubmed.ncbi.nlm.nih.gov

Earlier point-of-care ultrasound, shorter length of stay in patients with acute flank pain. [2022]

9. United States pubmed.ncbi.nlm.nih.gov

Point-of-care ultrasound with pocket-size devices in emergency department. [2020]

10. Germany pubmed.ncbi.nlm.nih.gov

[Point-of-care ultrasonography of the abdomen in emergency and intensive care medicine]. [2019]

11. Germany pubmed.ncbi.nlm.nih.gov

[Recommendations for education in ultrasound in medical intensive care and emergency medicine: position paper of DGIIN, DEGUM and DGK]. [2020]