← Back to Search

Exercise + Nicotinamide Riboside for Cancer Survivors with Insulin Resistance

N/A
Recruiting
Led By Rusha Bhandari
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Able to access online exercise program at home
Time between completion of cancer-directed therapy and study entry: >= 6 months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 weeks
Awards & highlights

Study Summary

This trial is testing the effect of exercise and nicotinamide riboside (a supplement similar to vitamin B3) on muscle health and insulin resistance in adult survivors of childhood cancer. The results may help develop regimens to improve these outcomes in future survivors.

Who is the study for?
Adult survivors of childhood cancer who are at least 18 years old, in remission for at least 6 months, and have prediabetes can join. They must be able to exercise at home using an online program, speak English, and sign a consent form. Those with pacemakers, recent NAD+ precursor use, diabetes medication use, MRI contraindications or current injuries cannot participate.Check my eligibility
What is being tested?
The trial is testing the combination of exercise and a vitamin B3-like supplement called Nicotinamide Riboside on muscle health and insulin resistance in adults who survived childhood cancer but now face prediabetes. The goal is to find ways to improve their metabolic health.See study design
What are the potential side effects?
Nicotinamide Riboside may cause mild side effects similar to those of vitamin supplements such as nausea or indigestion. Exercise might result in typical discomforts like muscle soreness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I can access an online exercise program from home.
Select...
It has been 6 months or more since I finished my cancer treatment.
Select...
I am 18 years old or older.
Select...
My cancer is currently in remission.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Malignant Neoplasms

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm II (home exercise, nicotinamide riboside)Experimental Treatment2 Interventions
Patients complete home exercise as in Arm I. Patients also receive nicotinamide riboside PO daily for 6 weeks.
Group II: Arm I (home exercise)Active Control1 Intervention
Patients complete 18 home exercise sessions over 30 minutes each, 3 days per weeks for 6 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nicotinamide Riboside
2022
N/A
~160

Find a Location

Who is running the clinical trial?

City of Hope Medical CenterLead Sponsor
561 Previous Clinical Trials
1,918,232 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,627 Previous Clinical Trials
40,927,375 Total Patients Enrolled
1 Trials studying Blood Cancers
70 Patients Enrolled for Blood Cancers
Rusha BhandariPrincipal InvestigatorCity of Hope Medical Center

Media Library

Blood Cancers Research Study Groups: Arm I (home exercise), Arm II (home exercise, nicotinamide riboside)
Blood Cancers Clinical Trial 2023: Exercise Intervention Highlights & Side Effects. Trial Name: NCT05023993 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals has the study recruited thus far?

"Yes, current information on clinicaltrials.gov confirms the active recruitment of participants for this project which was first posted on June 23rd 2022. The last update was done at the end of that month with a goal to enroll 20 patients from one site."

Answered by AI

Are recruitment efforts ongoing for this research project?

"As per the clinicaltrials.gov listing, this investigation is currently recruiting patients. This trial was first made public on June 23rd 2022 and its details have since been updated as recently as June 30th 2022."

Answered by AI
~4 spots leftby Sep 2024