Exercise + Nicotinamide Riboside for Cancer Survivors with Insulin Resistance

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: City of Hope Medical Center

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 18

Duration: 6 weeks

20 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial studies the effect of exercise and a vitamin-like supplement on muscle health and insulin resistance in adult survivors of childhood cancer with prediabetes. Participants will either do regular home exercise or do the same exercise while also taking a supplement similar to vitamin B3. The goal is to see if these interventions can improve their muscle health and how their body handles insulin.

Research Team

Rusha Bhandari

Principal Investigator

City of Hope Medical Center

Eligibility Criteria

Adult survivors of childhood cancer who are at least 18 years old, in remission for at least 6 months, and have prediabetes can join. They must be able to exercise at home using an online program, speak English, and sign a consent form. Those with pacemakers, recent NAD+ precursor use, diabetes medication use, MRI contraindications or current injuries cannot participate.

Inclusion Criteria

You can handle the specific exercise program given to you.

I can access an online exercise program from home.

It has been 6 months or more since I finished my cancer treatment.

Exclusion Criteria

You have a pacemaker.

You are unable to have a magnetic resonance imaging (MRI) scan for medical reasons.

I have taken a NAD+ precursor in the last two weeks.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants complete home exercise sessions and may receive nicotinamide riboside for 6 weeks

6 weeks

18 home exercise sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Exercise Intervention
• Nicotinamide Riboside

Trial Overview The trial is testing the combination of exercise and a vitamin B3-like supplement called Nicotinamide Riboside on muscle health and insulin resistance in adults who survived childhood cancer but now face prediabetes. The goal is to find ways to improve their metabolic health.

Participant Groups

Group I: Arm II (home exercise, nicotinamide riboside) Experimental Treatment 2 Interventions

Patients complete home exercise as in Arm I. Patients also receive nicotinamide riboside PO daily for 6 weeks.

Group II: Arm I (home exercise) Active Control 1 Intervention

Patients complete 18 home exercise sessions over 30 minutes each, 3 days per weeks for 6 weeks.

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials

614

Recruited

1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+