Carafate

Mucositis, Curling Ulcer, Indigestion + 9 more
Treatment
2 FDA approvals
20 Active Studies for Carafate

What is Carafate

SucralfateThe Generic name of this drug
Treatment SummarySucralfate is a medication used to protect cells in the gastrointestinal tract from damage caused by irritants like stomach acid, bile salts, alcohol, and aspirin. It is used to treat and prevent a range of gastrointestinal diseases such as duodenal ulcers, gastroesophageal reflux disease (GERD), gastritis, peptic ulcer disease, and stress ulcers. It is generally thought to be a safe drug with few side effects and is available in both tablet and suspension forms. Sucralfate was approved by the FDA in 1982 for tablet form and in 1994 for suspension form.
Carafateis the brand name
image of different drug pills on a surface
Carafate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Carafate
Sucralfate
1981
91

Approved as Treatment by the FDA

Sucralfate, otherwise known as Carafate, is approved by the FDA for 2 uses like active Duodenal ulcer and Duodenal Ulcer .
active Duodenal ulcer
Duodenal Ulcer

Effectiveness

How Carafate Affects PatientsThis drug helps heal duodenal ulcers by forming a protective barrier between the gastrointestinal tract and the substances that cause inflammation. It also increases the amount of growth factors and prostaglandins in the area, which help to heal the tissue lining the gastrointestinal tract.
How Carafate works in the bodySucralfate is used to help heal duodenal ulcers, but its exact mechanism of action is not yet known. It appears to form a protective barrier over the ulcer, blocking stomach acid and pepsin from damaging the tissue. It also increases levels of healing growth factors and prostaglandins in the area, and it is believed that it might also trap bile salts, which can cause further damage to the ulcer.

When to interrupt dosage

The recommended measure of Carafate is contingent upon the diagnosed condition, for example, Healing, Mucositis and Indigestion. Dosage varies in accordance with the approach of delivery outlined in the table beneath.
Condition
Dosage
Administration
Mucositis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Curling Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Indigestion
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Gastritis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Duodenal Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Healing
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Chemotherapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Stomach Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Peptic Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Stress Ulcers
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Anti-platelet Therapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Heartburn
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical

Warnings

Carafate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sucralfate may interact with Pulse Frequency
There are 20 known major drug interactions with Carafate.
Common Carafate Drug Interactions
Drug Name
Risk Level
Description
Deferasirox
Major
Sucralfate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir
Major
Sucralfate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
The serum concentration of Technetium Tc-99m oxidronate can be increased when it is combined with Sucralfate.
Abacavir
Minor
Sucralfate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abafungin
Minor
Sucralfate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Carafate Toxicity & Overdose RiskTaking too much sucralfate is unlikely to cause death, but may lead to constipation. Pregnant women should use this drug only if it is necessary for their health—studies on animals have not shown any harm to fetuses. It is currently unclear if this drug is excreted in breast milk, so caution should be taken when using it while nursing. No signs of cancer have been found in animals given up to 12 times the recommended human dose.
image of a doctor in a lab doing drug, clinical research

Carafate Novel Uses: Which Conditions Have a Clinical Trial Featuring Carafate?

Currently, there are 46 active clinical trials assessing the therapeutic potential of Carafate in managing Heartburn, Indigestion and Anti-platelet Therapy.
Condition
Clinical Trials
Trial Phases
Chemotherapy
3 Actively Recruiting
Phase 1, Phase 3, Not Applicable
Peptic Ulcer
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Indigestion
7 Actively Recruiting
Phase 3, Early Phase 1, Phase 2, Not Applicable, Phase 4
Stress Ulcers
0 Actively Recruiting
Duodenal Ulcer
0 Actively Recruiting
Anti-platelet Therapy
0 Actively Recruiting
Gastritis
0 Actively Recruiting
Stomach Ulcer
2 Actively Recruiting
Phase 4, Not Applicable
Healing
0 Actively Recruiting
Heartburn
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Phase 4
Mucositis
1 Actively Recruiting
Phase 2

Carafate Reviews: What are patients saying about Carafate?

5Patient Review
11/5/2016
Carafate for Inflammation of Esophagus from Backflow of Stomach Acid
Carafate has been a godsend. I've suffered from reflux for years, to the point where it was difficult to swallow. All medications gave me diarrhea- until Carafate.
5Patient Review
3/26/2019
Carafate for Heartburn
Carafate has made an incredible difference for me-- I haven't experienced any reflux and I'm able to eat without feeling sick constantly.
5Patient Review
5/31/2019
Carafate for Medication Treatment for Healing Stomach Ulcer
Sucrafate has been a game changer for me and my stomach problems. It's bland, easy to take without water, and really works fast. I'm so grateful to have found this medication.
5Patient Review
3/21/2015
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
I unfortunately always feel nauseous after taking this medication, to the point where I have difficulty eating.
5Patient Review
12/3/2015
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
Carafate is a great medication for those with hiatal hernias and GERD. It's not the most pleasant tasting drug, but it beats having GERD symptoms!
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about carafate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Carafate to work?

"Before taking Carafate, it is important to speak with a doctor. They will explain how long it may take to see the full benefits of the medicine. In some cases, it may only take a few weeks to see results, while in others it may take up to two months. It is important to follow the doctor's instructions and take the medicine for the full prescribed length of time, even if symptoms improve quickly. Once the active ulcer has healed, the doctor may want the patient to continue taking Carafate at a lower dose."

Answered by AI

What symptoms does Carafate help?

"Reflux esophagitis is the inflammation of the esophagus from the backflow of stomach acid. Gastroesophageal reflux disease is a stomach ulcer. The medication treatment for healing a stomach ulcer is an ulcer of the duodenum. The medication treatment for healing an ulcer of the duodenum is stress ulcer prevention."

Answered by AI

Is Carafate an antacid?

"Sucralfate is a medication used to treat duodenal ulcers. It works by healing the ulcer, but cannot be used to prevent future ulcers from occurring."

Answered by AI

What is Carafate used for?

"This medication is used to treat and prevent ulcers in the intestines. Sucralfate coats and protects ulcers, which helps them heal more quickly."

Answered by AI

Clinical Trials for Carafate

Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.
Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.
Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.
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