Phrenilin Forte
Inadequate analgesia, Tension-Type Headache
Treatment
3 FDA approvals
0 Active Studies for Phrenilin Forte
Treatment for
Inadequate analgesia
What is Phrenilin Forte
Butalbital
The Generic name of this drug
Treatment Summary
Acetaminophen, also known as Tylenol, is a pain reliever and fever reducer that is widely used around the world. It comes in many forms, such as syrup, tablets, injections, and suppositories. Acetaminophen is often found in combination with other drugs in many over-the-counter medications for allergies, colds, sleep, and pain relief. It is important to follow the recommended dosing guidelines from national and manufacturer sources when taking acetaminophen, as incorrect use can lead to fatal overdose and liver failure.
Fiorinal
is the brand name
Phrenilin Forte Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fiorinal
Butalbital
1976
283
Approved as Treatment by the FDA
Butalbital, also known as Fiorinal, is approved by the FDA for 3 uses such as Tension-Type Headache and Tension Headache .
Tension-Type Headache
Used to treat Tension Headache in combination with Acetaminophen
Tension Headache
Used to treat Tension Headache in combination with Acetaminophen
Inadequate analgesia
Used to treat Inadequate analgesia in combination with Acetaminophen
Effectiveness
How Phrenilin Forte Affects Patients
Research on animals and humans has shown that acetaminophen is effective for reducing fever and pain. It does not have anti-inflammatory effects like other drugs, and won't cause problems with uric acid levels or acid-base balance when taken as directed. Acetaminophen also has no effect on blood clotting, and allergic reactions after taking it are uncommon.
How Phrenilin Forte works in the body
Acetaminophen relieves pain by interfering with the production of prostaglandins, chemicals that can cause pain. It does this by targeting two types of cyclooxygenase (COX) enzymes, COX-1 and COX-2. Acetaminophen has no anti-inflammatory effects on its own, but studies suggest it may block a third type of COX enzyme, called COX-3. Acetaminophen also has antipyretic actions, which means it lowers fever by affecting the temperature control center in the brain. The exact way acetaminophen works is still unclear, but further research
When to interrupt dosage
The suggested dosage of Phrenilin Forte is contingent upon the diagnosed circumstance, such as Pain, Spasm and Inflammation. The amount of dosage can be found in the table below, based on the method of administration.
Condition
Dosage
Administration
Tension-Type Headache
, 50.0 mg, 5.0 mg/mL, 25.0 mg, 25.0 mg/mg
Capsule, Tablet, , Oral, Tablet - Oral, Capsule - Oral, Syrup, Syrup - Oral, Tablet, coated - Oral, Tablet, coated
Inadequate analgesia
, 50.0 mg, 5.0 mg/mL, 25.0 mg, 25.0 mg/mg
Capsule, Tablet, , Oral, Tablet - Oral, Capsule - Oral, Syrup, Syrup - Oral, Tablet, coated - Oral, Tablet, coated
Warnings
Phrenilin Forte Contraindications
Condition
Risk Level
Notes
Porphyrias
Do Not Combine
Post-Tonsillectomy
Do Not Combine
Porphyrias
Do Not Combine
post-adenoidectomy
Do Not Combine
There are 20 known major drug interactions with Phrenilin Forte.
Common Phrenilin Forte Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Butalbital.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Butalbital.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Butalbital.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Butalbital.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Butalbital.
Phrenilin Forte Toxicity & Overdose Risk
Acetaminophen is toxic if taken in too high of a dose. Signs of overdose include kidney damage, low blood sugar, low platelet count, and liver damage which can lead to death or the need for a liver transplant. NAPQI, a toxic metabolite of acetaminophen, is responsible for the toxic effects of the drug. Long-term studies in mice and rats have not shown any signs of cancer, but the drug can cause mutations at high doses. Acetaminophen has not been shown to affect fertility or cause any adverse effects in pregnant or nursing women, although it is advised to use caution when taking
Phrenilin Forte Novel Uses: Which Conditions Have a Clinical Trial Featuring Phrenilin Forte?
698 active clinical trials are investigating the possibility of Phrenilin Forte to alleviate Chronic Pain, Rheumatoid Arthritis and Allergic reactions.
Condition
Clinical Trials
Trial Phases
Inadequate analgesia
0 Actively Recruiting
Tension-Type Headache
0 Actively Recruiting
Phrenilin Forte Reviews: What are patients saying about Phrenilin Forte?
5
Patient Review
11/18/2013
Phrenilin Forte for Tension Headache
5
Patient Review
5/26/2009
Phrenilin Forte for Tension Headache
5
Patient Review
5/2/2009
Phrenilin Forte for Tension Headache
4
Patient Review
1/20/2009
Phrenilin Forte for Tension Headache
3.7
Patient Review
1/3/2008
Phrenilin Forte for Tension Headache
2
Patient Review
11/30/2007
Phrenilin Forte for Tension Headache
Patient Q&A Section about phrenilin forte
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is Phrenilin available?
"The Phrenilin brand has been discontinued in the U.S., but generic versions may be available if they have been approved by the FDA."
Answered by AI
What is Phrenilin Forte used for?
"The medication is a combination of acetaminophen and butalbital. It is used to treat tension headaches by decreasing pain and causing sleepiness and relaxation."
Answered by AI
Will butalbital make you sleepy?
"Barbiturates like butalbital can make people drowsy, but sometimes children get excited instead."
Answered by AI
What is the drug butalbital used for?
"This medication is a pain reliever and relaxant that is used to treat tension headaches. It contains butalbital, which belongs to the group of medicines called barbiturates. These drugs work by acting on the central nervous system to produce their effects."
Answered by AI