Trokendi Xr

Migraine, Caloric Restriction, High cholesterol + 16 more
Treatment
20 Active Studies for Trokendi Xr

What is Trokendi Xr

TopiramateThe Generic name of this drug
Treatment SummaryTopiramate is an anticonvulsant medication used to treat seizures and prevent migraines. It was first approved by the FDA in 1996. In 2004, it was also approved for the prevention of migraines in adults. Since 2012, it has been approved in combination with phentermine to help adults manage their weight. It has a unique chemical structure and is made up of 40% oxygen. It was created when scientists were trying to create a new diabetes drug.
Topamaxis the brand name
image of different drug pills on a surface
Trokendi Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Topamax
Topiramate
1997
526

Effectiveness

How Trokendi Xr Affects PatientsTopiramate is used to prevent seizures and treat migraine symptoms by decreasing activity in the brain. It may cause dangerous side effects such as metabolic acidosis, mood changes, suicidal thoughts and attempts, and kidney stones. When taken with valproic acid, topiramate can also lead to hypothermia.
How Trokendi Xr works in the bodySeizures are caused by uncontrolled electrical activity in the brain. Topiramate works to reduce this activity in order to treat seizures and migraines. It does this by affecting GABA receptors, which normally inhibit nerve activity, and glutamate receptors, which stimulate activity. By increasing GABA activity and decreasing glutamate activity, topiramate blocks nerve signals from firing, preventing seizures and migraines. It also blocks voltage-dependent sodium channels in the brain, another way of reducing seizure activity. It is also known to affect certain carbonic anhydrase molecules, but we don't know what effect this has yet.

When to interrupt dosage

The prescribed measure of Trokendi Xr is contingent upon the diagnosed state, such as Seizures, Weight Reduction and Tonic - clonic seizures. The amount of dosage can be found in the table below, depending on the administration technique (e.g. Tablet, coated or Tablet).
Condition
Dosage
Administration
Alcoholism
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
High cholesterol
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
at least one weight-related comorbid condition
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
prophylaxis of migraine headaches
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Type 2 Diabetes
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Hypertensive disease
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Caloric Restriction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight Reduction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Lennox Gastaut Syndrome (LGS)
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
increase in physical activity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Chronic Weight Management therapy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Exercise
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
BMI >27 kg/m2
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Seizures
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Epilepsy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Mood Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Migraine
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Warnings

Trokendi Xr Contraindications
Condition
Risk Level
Notes
Metabolic Acidosis
Do Not Combine
There are 20 known major drug interactions with Trokendi Xr.
Common Trokendi Xr Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Topiramate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Topiramate.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Topiramate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Topiramate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Topiramate.
Trokendi Xr Toxicity & Overdose RiskRats have been found to tolerate doses of up to 1500mg/kg of topiramate. In humans, overdosing on topiramate can cause symptoms ranging from mild to severe, such as low blood pressure, extreme acidosis, abdominal pain, seizures, confusion, dizziness, depression, and more. To treat an overdose, doctors may induce vomiting, give activated charcoal, or use dialysis.
image of a doctor in a lab doing drug, clinical research

Trokendi Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Trokendi Xr?

At present, there are 313 active trials investigating the potential of Trokendi Xr to address Type 2 Diabetes, Migraine and Exercise-associated conditions.
Condition
Clinical Trials
Trial Phases
prophylaxis of migraine headaches
0 Actively Recruiting
Weight
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
High cholesterol
4 Actively Recruiting
Phase 2, Phase 1
Type 2 Diabetes
191 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Seizures
2 Actively Recruiting
Phase 3
increase in physical activity
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
BMI >27 kg/m2
0 Actively Recruiting
Weight Reduction
1 Actively Recruiting
Not Applicable
at least one weight-related comorbid condition
0 Actively Recruiting
Epilepsy
0 Actively Recruiting
Obesity
0 Actively Recruiting
Alcoholism
8 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Mood Disorders
1 Actively Recruiting
Not Applicable
Lennox Gastaut Syndrome (LGS)
3 Actively Recruiting
Phase 2, Phase 3
Exercise
54 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3

Trokendi Xr Reviews: What are patients saying about Trokendi Xr?

5Patient Review
1/16/2020
Trokendi Xr for Migraine Prevention
I was 60 when I developed cluster headaches. tried Topamax regular and had the same side effects as others have described. My neuro switched me to the 25mg XR, and no more side effects, and about 1 cluster headache per year now.
4.7Patient Review
11/13/2017
Trokendi Xr for Migraine Prevention
I've only had one migraine in the five months since I started this treatment, which is amazing because I was getting them two to three times a week previously. .25m at night does the trick for me with no negative side effects that I can tell.
4.3Patient Review
1/10/2018
Trokendi Xr for Essential Tremor
Trokendi XR was recommended to me by my doctor, and I'm glad I gave it a try. After trying out different strengths, I found that the 50mg dosage worked best for me in terms of reducing hand shaking and other symptoms. The generic version didn't work as well for me, so be aware of that when you're considering this drug.
2.3Patient Review
5/31/2018
Trokendi Xr for Migraine Prevention
At first, this medication seemed to help. I increased the dosage from 25mg to 50mg to 100mg. However, at 100mg I felt completely useless and bedridden. Tingling in my fingers and feet was a constant issue throughout the entire process. Now that I'm stopping the medication, I'm experiencing bone pain, tingling fingers and feet, frequent urination, back pain, and signs of kidney stones – all considered serious side effects.
1.7Patient Review
11/29/2021
Trokendi Xr for Migraine Prevention
Dizziness, slurred speech, short term memory loss, no energy, loss of appetite, forgetful, frequent urination with incontence, hair breaking/ loss, very brittle finger / toe nails, increase headaches. These are just some of the issues I experienced while taking this medication. Please do not take it. I went cold turkey and after a bit more than two weeks felt so much better. Also able to start managing my life again.
1Patient Review
5/12/2018
Trokendi Xr for Migraine Prevention
I have only been taking Trokendi for a short while, but it has already caused me serious problems. I started hallucinating a few hours after taking the medication, and it has made my speech slurred and walking difficult. I will be asking my neurologist to take me off this med as soon as possible. It also is not helping my migraines at all and has given me terrible acne.
1Patient Review
1/10/2020
Trokendi Xr for Migraine Prevention
I was taking topiramate 25mg twice daily and it helped reduce my migraines to about 2-3 per month. However, when my neuro prescribed Trokendi XR at 25mg and then 50mg, my migraines came back with a vengeance. I'm going back on the topiramate soon if things don't improve.
1Patient Review
5/10/2021
Trokendi Xr for Migraine Prevention
This medication was extremely dangerous and almost killed me. I lost 30 pounds as a result of taking it, and my BP plummeted to 53/30. I also developed neuropathy in both hands (which is now permanent) and suffered from fatigue, hair loss, and nail loss. This medication ruined my life and I would urge anyone considering taking it to avoid doing so at all costs.
1Patient Review
9/10/2021
Trokendi Xr for Migraine Prevention
The side effects were really intense and debilitating. I felt constantly dizzy, my speech was slurred, and I had a lot of trouble concentrating or thinking clearly. On top of all that, I also experienced extreme anxiety. Luckily, I only lost 12 pounds in the two weeks that I took this medication.
1Patient Review
4/15/2019
Trokendi Xr for Migraine Prevention
I had terrible side effects that began after only six weeks of taking the medication. I was constantly feeling low, exhausted, and anxious. If you have any history of mental illness or depression, I would not recommend this drug. It made me feel insane. Within two days of stopping the medication, most of the side effects dissipated. However, I still suffer from migraines on a daily basis.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about trokendi xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Trokendi XR make you sleepy?

"Trokendi may cause tiredness, sleepiness, drowsiness, dizziness, changes in vision, and slowed reactions. The use of alcohol with Trokendi may increase these side effects."

Answered by AI

What is Trokendi XR used for?

"Trokendi XR is a prescription medicine that is used to prevent migraines in adults and adolescents who are at least 12 years old. It is also used to treat certain types of seizures in people who are at least 6 years old."

Answered by AI

Is Trokendi XR the same as Topamax?

"Both drugs contain the same active ingredient called topiramate. Trokendi XR comes as an extended-release (long-acting) oral capsule and Topamax come as an immediate-release tablet or capsule. Trokendi XR is taken once a day, while Topamax is usually taken twice a day, in the morning and evening."

Answered by AI

Is Trokendi XR used for weight loss?

"While Trokendi XR is not approved as a weight loss medication, it is common for patients to lose weight while taking the drug, especially at higher doses. Your doctor may prescribe Trokendi XR off-label for binge eating disorder. If you have questions about Trokendi XR and weight loss, speak with your doctor."

Answered by AI

Clinical Trials for Trokendi Xr

Have you considered Trokendi Xr clinical trials? We made a collection of clinical trials featuring Trokendi Xr, we think they might fit your search criteria.
Have you considered Trokendi Xr clinical trials? We made a collection of clinical trials featuring Trokendi Xr, we think they might fit your search criteria.
Have you considered Trokendi Xr clinical trials? We made a collection of clinical trials featuring Trokendi Xr, we think they might fit your search criteria.