Lamictal Xr

Bipolar Disorder, Seizures, Seizures + 3 more
Treatment
4 FDA approvals
7 Active Studies for Lamictal Xr

What is Lamictal Xr

LamotrigineThe Generic name of this drug
Treatment SummaryLamotrigine is a drug used to treat epileptic seizures and stabilize moods in people with bipolar disorder. It is the first medication to receive FDA approval for the long-term treatment of bipolar disorder type I. Lamotrigine is approved in over 30 countries and has few side effects, making it a safe and reliable treatment option. Additionally, it has demonstrated some effectiveness in treating certain types of nerve pain.
Lamictalis the brand name
image of different drug pills on a surface
Lamictal Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lamictal
Lamotrigine
1995
543

Approved as Treatment by the FDA

Lamotrigine, also known as Lamictal, is approved by the FDA for 4 uses such as Partial-Onset Seizures and Seizures .
Partial-Onset Seizures
Seizures
Currently on standardized therapy
Conversion to monotherapy

Effectiveness

How Lamictal Xr Affects PatientsLamotrigine is thought to help prevent seizures and mood problems by stabilizing cell membranes and stopping the release of certain brain chemicals. It has been reported that a metabolite of lamotrigine, 2-N-methyl metabolite, can lead to changes in the heart rhythm when taken in large doses. This metabolite is only found in small amounts in humans, but can be more present in people with liver disease.
How Lamictal Xr works in the bodyLamotrigine works by blocking certain sodium channels, which helps stabilize and regulate the release of certain neurotransmitters in the brain. This is thought to be how lamotrigine helps reduce seizures, bipolar disorder, and other conditions. Lamotrigine also binds to different receptors in the body, including serotonin, dopamine, and GABA receptors, which may also contribute to its therapeutic effects. It also has an effect on calcium channels, which could help explain its anticonvulsant action.

When to interrupt dosage

The recommended measure of Lamictal Xr is contingent upon the diagnosed affliction, including Bipolar Disorder, Seizures and Lennox Gastaut Syndrome (LGS). The quantity of dosage is dependent on the means of delivery as detailed in the table below.
Condition
Dosage
Administration
Conversion to monotherapy
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Lennox Gastaut Syndrome
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Seizures
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Bipolar Disorder
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Seizures
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Currently on standardized therapy
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral

Warnings

Lamictal Xr Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lamotrigine may interact with Pulse Frequency
There are 20 known major drug interactions with Lamictal Xr.
Common Lamictal Xr Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Lamotrigine is combined with Aclidinium.
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Lamotrigine.
Azelastine
Major
Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Lamotrigine.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Lamotrigine.
Lamictal Xr Toxicity & Overdose RiskThe lowest toxic dose of lamotrigine in mice and rats has been found to be 205 mg/kg and 245 mg/kg respectively. In cases of overdose, symptoms may include difficulty walking, involuntary eye movements, increased seizures, loss of consciousness, coma, and slowed electrical signals in the heart. There is no known antidote for an overdose of lamotrigine, but hospitalization and supportive care should be administered. Doctors may choose to use stomach pumping or vomiting to remove the drug from the body, and dialysis may be used to help remove lamotrigine from the blood.
image of a doctor in a lab doing drug, clinical research

Lamictal Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Lamictal Xr?

8 active clinical trials are presently assessing the potential of Lamictal Xr to alleviate Seizures, Seizures and Lennox-Gastaut Syndrome (LGS).
Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Seizures
0 Actively Recruiting
Lennox Gastaut Syndrome
3 Actively Recruiting
Phase 2, Phase 1, Phase 4
Seizures
4 Actively Recruiting
Phase 3, Phase 2
Conversion to monotherapy
0 Actively Recruiting
Currently on standardized therapy
0 Actively Recruiting

Lamictal Xr Reviews: What are patients saying about Lamictal Xr?

5Patient Review
9/20/2011
Lamictal Xr for Bipolar Depression
I have complex partial seizures and I take 400 mg Lamictal XR 2x a day and 100 topamax at bed. I had some problems when I started taking it, but that's not unusual for me whenever I start a new medication. It's worked well for my seizures though.
5Patient Review
11/9/2013
Lamictal Xr for Simple Partial Seizures
This medication has completely stopped my seizures and rage. I only have to take it once a day, but I do have to take it at night because it makes me drowsy.
5Patient Review
7/19/2015
Lamictal Xr for Convulsive Seizures
I can't speak highly enough of this medicine- it really did the trick for me.
4.3Patient Review
3/4/2011
Lamictal Xr for Bipolar Depression
I've been struggling with headaches, teeth grinding, and excessive blinking (which causes joint and jaw pain). I'm also having issues with my memory, which seems to be getting worse every day. Today, I actually forgot how old I was.
4Patient Review
12/29/2010
Lamictal Xr for Convulsive Seizures
I was diagnosed with partial seizures and put on this medication. At first, I thought it was working; however, after about a month and a half, I developed a horrible rash that covered my body. I don't think the benefits are worth the side effects.
View All Reviews
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Patient Q&A Section about lamictal xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lamictal extended-release?

"The LAMICTAL XR extended-release tablets are available in yellow, green, orange, blue, purple, and gray, each with a white center. They are supplied in oral doses of 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, and 300 mg."

Answered by AI

What is Lamictal ER for?

"Lamotrigine ER (Lamictal XR) is a drug that is used to control seizures in adults and children with epilepsy. It is less popular than some other similar drugs, but it is still available in both brand and generic versions."

Answered by AI

How long does lamotrigine XR last?

"Lamotrigine will stay in your system for about 338.8 hours (approximately 14 days) after your last dose. After multiple doses (in volunteers who took no other medicines), the elimination half-life of lamotrigine is 11.6 to 61.6 hours."

Answered by AI

What is Lamictal XR used for?

"Lamotrigine, marketed as Lamictal XR, is an anti-epileptic drug used to treat seizures in adults and children aged two years and up. It can be used alone or in combination with other medications. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder."

Answered by AI

Clinical Trials for Lamictal Xr

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