What is Depacon
Valproic acidThe Generic name of this drug
Treatment SummaryValproic acid, or valproate, is a medication that was first used as an organic solvent in industry and pharmaceuticals in 1881. In 1963, it was discovered to have anticonvulsant properties and was approved by the FDA in 1978 under the trade name Depakene. Today, valproic acid is used to treat seizures, mania, migraines, and may even have neuroprotective and anti-cancer effects. It is currently being studied in clinical trials to investigate its potential as an anti-proliferative drug for cancer treatment.
Depakeneis the brand name
Depacon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depakene
Valproic acid
1978
481
Effectiveness
How Depacon Affects PatientsValproate can help reduce the number of complex partial seizures and migraine headaches, and is also thought to aid in the control of bipolar mania. It's not fully understood how it works, but it is believed to help by increasing the amount of inhibition in the brain. Valproate has been found to also help protect the brain from damage and neural degeneration, but it can also be toxic to the liver and cause birth defects. A small study suggested that it might help with HIV clearance when taken with other treatments, but a larger study did not find any significant effect. The FDA warns that HIV may become reactivated when taking Val
How Depacon works in the bodyValproate works in a variety of ways to help treat epilepsy, migraine headaches, and bipolar disorder. It reduces the amount of GABA being broken down, which is an inhibitory neurotransmitter. This increase in GABA activity results in increased inhibition in the brain. Valproate also affects pathways related to cell growth and survival, as well as fatty acid metabolism, which can reduce inflammation. Finally, it works as a direct inhibitor of histone deactylase, which can lead to changes in gene expression. These effects combined work to reduce seizures, decrease inflammation, and improve symptoms associated with bipolar disorder.
When to interrupt dosage
The prescribed dosage of Depacon is contingent upon the affirmed condition, including Seizures, Seizure, Absence and Complex Partial Seizures. The amount of dosage can be found in the table below, dependent upon the technique of delivery (e.g. Injection, solution - Intravenous or Capsule, delayed release).Condition
Dosage
Administration
Behcet Syndrome
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Complex Partial Seizures
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Seizure, Absence
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Acute Coryza
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Migraine
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Mental Depression
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Seizures
500.0 mg, , 250.0 mg, 100.0 mg/mL, 125.0 mg, 250.0 mg/mL, 500.0 mg/mL, 50.0 mg/mL
Injection, solution - Intravenous, Capsule, delayed release, Tablet, delayed release, , Tablet, extended release, Liquid, Oral, Intravenous, Capsule, liquid filled, Tablet, extended release - Oral, Syrup, Tablet, film coated, Capsule, liquid filled - Oral, Capsule - Oral, Liquid - Intravenous, Capsule, delayed release - Oral, Injection - Intravenous, Injection, solution, Tablet, delayed release - Oral, Injection, Solution, Capsule, coated pellets - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Solution - Oral, Capsule, Delayed Release - Oral, Tablet, delayed release particles, Tablet, film coated, extended release, Tablet, delayed release particles - Oral, Tablet, Capsule, Syrup - Oral, Capsule, coated pellets, Capsule, Delayed Release, Tablet - Oral
Warnings
Depacon ContraindicationsCondition
Risk Level
Notes
Disease
Do Not Combine
Significant hepatic impairment
Do Not Combine
POLG-related disorder
Do Not Combine
Hepatic Disease
Do Not Combine
Enzymes
Do Not Combine
Common Depacon Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Valproic acid.
Acalabrutinib
Major
The serum concentration of Acalabrutinib can be increased when it is combined with Valproic acid.
Alectinib
Major
The serum concentration of Alectinib can be increased when it is combined with Valproic acid.
Aminophylline
Major
The serum concentration of Aminophylline can be increased when it is combined with Valproic acid.
Amiodarone
Major
The serum concentration of Amiodarone can be increased when it is combined with Valproic acid.
Depacon Toxicity & Overdose RiskThe amount of Valproate that is toxic to mice is 1098mg/kg and 670mg/kg for rats. Symptoms of an overdose can include drowsiness, abnormal heart rhythm, deep unconsciousness, high sodium levels, and in some cases death. Hemodialysis can be used to remove the drug from the body. Valproate use during pregnancy can increase the risk of birth defects such as neural tube defects, facial defects, and other physical abnormalities. It can also lead to lower IQ and autism spectrum disorder in children. Valproate can be found in breast milk and has been linked to male infertility. It should
Depacon Novel Uses: Which Conditions Have a Clinical Trial Featuring Depacon?
65 active clinical trials are being conducted to examine the possibility of deploying Depacon as a potential therapy for Migraine, Complex Partial Seizures and Acute Coryza.Condition
Clinical Trials
Trial Phases
Acute Coryza
1 Actively Recruiting
Not Applicable
Migraine
53 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3
Seizures
0 Actively Recruiting
Complex Partial Seizures
0 Actively Recruiting
Seizure, Absence
0 Actively Recruiting
Behcet Syndrome
2 Actively Recruiting
Not Applicable
Mental Depression
3 Actively Recruiting
Not Applicable, Phase 2
Patient Q&A Section about depacon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Depakote and Depacon the same?
"Depacon is a drug that is very similar to Depakene and Depakote. It is often referred to as valproate. In the United Kingdom, it is marketed by Sanofi under the brand Epilim."
Answered by AI
Is Depacon valproic acid?
"Valproate products are sometimes used to treat conditions other than the ones they are approved for. These products include valproate sodium, divalproex sodium, valproic acid, and their generics."
Answered by AI
What is Depacon migraine?
"Depacon is used more frequently in patients who have epilepsy to achieve rapid titration of medication or who cannot take their medication orally. Depacon has the same indications as oral valproic acid, such as migraine prophylaxis, generalized and partial seizures, and bipolar illness."
Answered by AI
What is Depacon used for?
"Depacon is an anti-seizure medication that can be used by itself or along with other seizure medications to treat complex partial seizures, which are seizures that can happen alone or with other types of seizures."
Answered by AI