Depacon

Migraine, Acute Coryza, Behcet Syndrome + 4 more
Treatment
20 Active Studies for Depacon

What is Depacon

Valproic acidThe Generic name of this drug
Treatment SummaryValproic acid, or valproate, is a medication that was first used as an organic solvent in industry and pharmaceuticals in 1881. In 1963, it was discovered to have anticonvulsant properties and was approved by the FDA in 1978 under the trade name Depakene. Today, valproic acid is used to treat seizures, mania, migraines, and may even have neuroprotective and anti-cancer effects. It is currently being studied in clinical trials to investigate its potential as an anti-proliferative drug for cancer treatment.
Depakeneis the brand name
image of different drug pills on a surface
Depacon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depakene
Valproic acid
1978
481

Effectiveness

How Depacon Affects PatientsValproate can help reduce the number of complex partial seizures and migraine headaches, and is also thought to aid in the control of bipolar mania. It's not fully understood how it works, but it is believed to help by increasing the amount of inhibition in the brain. Valproate has been found to also help protect the brain from damage and neural degeneration, but it can also be toxic to the liver and cause birth defects. A small study suggested that it might help with HIV clearance when taken with other treatments, but a larger study did not find any significant effect. The FDA warns that HIV may become reactivated when taking Val
How Depacon works in the bodyValproate works in a variety of ways to help treat epilepsy, migraine headaches, and bipolar disorder. It reduces the amount of GABA being broken down, which is an inhibitory neurotransmitter. This increase in GABA activity results in increased inhibition in the brain. Valproate also affects pathways related to cell growth and survival, as well as fatty acid metabolism, which can reduce inflammation. Finally, it works as a direct inhibitor of histone deactylase, which can lead to changes in gene expression. These effects combined work to reduce seizures, decrease inflammation, and improve symptoms associated with bipolar disorder.

When to interrupt dosage

The prescribed dosage of Depacon is contingent upon the affirmed condition, including Seizures, Seizure, Absence and Complex Partial Seizures. The amount of dosage can be found in the table below, dependent upon the technique of delivery (e.g. Injection, solution - Intravenous or Capsule, delayed release).
Condition
Dosage
Administration
Mental Depression
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Seizures
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Migraine
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Acute Coryza
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Behcet Syndrome
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Epilepsy
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release
Seizures
, 250.0 mg, 125.0 mg, 500.0 mg, 250.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 500.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, delayed release particles, Tablet, delayed release particles - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Injection, Injection - Intravenous, Syrup, Syrup - Oral, Liquid, Liquid - Intravenous, Capsule, Delayed Release - Oral, Capsule, Delayed Release

Warnings

Depacon Contraindications
Condition
Risk Level
Notes
Mitochondrial Diseases
Do Not Combine
Liver Failure
Do Not Combine
Disease
Do Not Combine
Liver Diseases
Do Not Combine
Enzymes
Do Not Combine
There are 20 known major drug interactions with Depacon.
Common Depacon Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Valproic acid.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Valproic acid.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Valproic acid.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Valproic acid.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Valproic acid.
Depacon Toxicity & Overdose RiskThe amount of Valproate that is toxic to mice is 1098mg/kg and 670mg/kg for rats. Symptoms of an overdose can include drowsiness, abnormal heart rhythm, deep unconsciousness, high sodium levels, and in some cases death. Hemodialysis can be used to remove the drug from the body. Valproate use during pregnancy can increase the risk of birth defects such as neural tube defects, facial defects, and other physical abnormalities. It can also lead to lower IQ and autism spectrum disorder in children. Valproate can be found in breast milk and has been linked to male infertility. It should
image of a doctor in a lab doing drug, clinical research

Depacon Novel Uses: Which Conditions Have a Clinical Trial Featuring Depacon?

65 active clinical trials are being conducted to examine the possibility of deploying Depacon as a potential therapy for Migraine, Complex Partial Seizures and Acute Coryza.
Condition
Clinical Trials
Trial Phases
Migraine
52 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Seizures
0 Actively Recruiting
Seizures
0 Actively Recruiting
Acute Coryza
1 Actively Recruiting
Not Applicable
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Epilepsy
0 Actively Recruiting
Mental Depression
1 Actively Recruiting
Not Applicable

Patient Q&A Section about depacon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Depakote and Depacon the same?

"Depacon is a drug that is very similar to Depakene and Depakote. It is often referred to as valproate. In the United Kingdom, it is marketed by Sanofi under the brand Epilim."

Answered by AI

Is Depacon valproic acid?

"Valproate products are sometimes used to treat conditions other than the ones they are approved for. These products include valproate sodium, divalproex sodium, valproic acid, and their generics."

Answered by AI

What is Depacon migraine?

"Depacon is used more frequently in patients who have epilepsy to achieve rapid titration of medication or who cannot take their medication orally. Depacon has the same indications as oral valproic acid, such as migraine prophylaxis, generalized and partial seizures, and bipolar illness."

Answered by AI

What is Depacon used for?

"Depacon is an anti-seizure medication that can be used by itself or along with other seizure medications to treat complex partial seizures, which are seizures that can happen alone or with other types of seizures."

Answered by AI

Clinical Trials for Depacon

Have you considered Depacon clinical trials? We made a collection of clinical trials featuring Depacon, we think they might fit your search criteria.
Have you considered Depacon clinical trials? We made a collection of clinical trials featuring Depacon, we think they might fit your search criteria.
Have you considered Depacon clinical trials? We made a collection of clinical trials featuring Depacon, we think they might fit your search criteria.
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