Visual Adaptation for Visual Snow
(VPVSS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it does exclude participants with current substance dependence or recent hallucinogenic substance use.
Is Visual Adaptation safe for humans?
How does the Visual Adaptation treatment for Visual Snow differ from other treatments?
The Visual Adaptation treatment for Visual Snow is unique because it focuses on adapting the visual system to dynamic visual inputs, using a model that learns and adjusts to the statistical regularities of natural visual stimuli. This approach is different from other treatments as it aims to optimize visual processing by normalizing current visual input based on past inputs, potentially offering a novel way to manage symptoms by leveraging the brain's natural adaptation mechanisms.46789
What is the purpose of this trial?
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are:* Does VSS arise from spontaneous activity in brain pathways?* Where in the brain does the activity contributing to VSS arise?* How does brain activity contribute to VSS?Participants will:1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function.2. Make visual judgements based on images presented to them both inside and outside a magnetic resonance imaging (MRI) machine.3. Undergo scanning of their brain while inside of an MRI machine.
Research Team
Carrie E Robertson, M.D.
Principal Investigator
Mayo Clinic, Rochester, Department of Neurology
Abby Metzler, M.D.
Principal Investigator
University of Minnesota, Department of Neurology
Malgorzata Marjanska, Ph.D.
Principal Investigator
University of Minnesota, Department of Radiology
Michael-Paul Schallmo, Ph.D.
Principal Investigator
University of Minnesota, Department of Psychiatry and Behavioral Sciences
Stephen A Engel, Ph.D.
Principal Investigator
University of Minnesota, Department of Psychology
Michael S Lee, M.D.
Principal Investigator
University of Minnesota, Department of Ophthalmology and Visual Neurosciences
Eligibility Criteria
This trial is for individuals with Visual Snow Syndrome (VSS), those experiencing postprandial fullness or migraines, and healthy volunteers. Participants should be able to undergo MRI scans and complete various assessments and questionnaires related to visual and mental symptoms.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Assessment
Participants undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function
Visual Judgement and MRI
Participants make visual judgements based on images and undergo MRI scanning
Follow-up
Participants are monitored for safety and effectiveness after assessments
Treatment Details
Interventions
- Visual Adaptation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
Mayo Clinic
Collaborator
National Eye Institute (NEI)
Collaborator