Radiation Therapy for Breast Cancer
(FAST NOVEMBER Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot take medications that make radiation more effective during the study.
What data supports the effectiveness of the treatment Whole Breast Radiotherapy for breast cancer?
Is radiation therapy for breast cancer generally safe for humans?
Radiation therapy for breast cancer, including whole-breast radiotherapy, is generally safe when proper techniques are used, though some patients may experience skin reactions or other side effects. Accelerated partial breast irradiation with brachytherapy has a very low risk profile and fewer late side effects compared to whole-breast irradiation.678910
How is whole breast radiotherapy different from other breast cancer treatments?
Whole breast radiotherapy (WBRT) is unique because it targets the entire breast, reducing the risk of cancer returning in the breast area after breast-conserving surgery. It is often used as a standard treatment to prevent recurrence and can be delivered in a shorter, hypofractionated schedule, which means fewer sessions with a higher dose per session, compared to traditional longer schedules.14111213
What is the purpose of this trial?
The goal of this study is to evaluate 5 days vs. 9 days of whole breast radiation.
Research Team
Matthew R. Poppe, MD
Principal Investigator
Huntsman Cancer Institute
Eligibility Criteria
This trial is for women aged 18 or older with early-stage breast cancer who've had a lumpectomy. They must not be pregnant, agree to use contraception if of childbearing potential, and have an ECOG Performance Status ≤ 2 or KPS ≥ 50. Women over 50 need additional risk factors like aggressive tumor grade or low estrogen receptor positivity.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive either 5 or 9 fractions of whole breast radiotherapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants are monitored for long-term radiation-related adverse events and recurrence rates
Treatment Details
Interventions
- Whole Breast Radiotherapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor