Reviewed by Michael Gill, B. Sc.
25 Epilepsy Clinical Trials Near Me
Top Hospitals for Epilepsy Clinical Trials
Top Cities for Epilepsy Clinical Trials
Epilepsy Clinical Trials by Phase of Trial
Phase < 1 Epilepsy Clinical Trials
6Active Epilepsy Clinical Trials
6Number of Unique Treatments
3Number of Active Locations
Intracranial electroencephalography recordingsEmpagliflozin 25 mgBrain Interchange SystemScopolamine (5ug/kg)transcranial direct current stimulation (tDCS)PS and OS stimulation order 3
Epilepsy Clinical Trials by Age Group
< 18 Epilepsy Clinical Trials
14Active Epilepsy Clinical Trials
XEN496Lacosamide oralMusic StimuliDiazepam Nasal Spray [Valtoco]RNS SystemXEN496e-health applicationIndividualized Adherence Feedback Report
Most Recent Epilepsy Clinical Trials
Top Treatments for Epilepsy Clinical Trials
Treatment Name
Active Epilepsy Clinical Trials
All Time Trials for Epilepsy
First Recorded Epilepsy Trial
Speech Tasks
2
2
2015
XEN496
2
2
2021
Perampanel
2
19
2006
Brivaracetam
2
22
2005
Cenobamate
2
2
2018
Recently Completed Studies with FDA Approved Treatments for Epilepsy
Treatment
Year
Sponsor
NBI-827104
2021
Neurocrine Biosciences
Ganaxolone
2019
Marinus Pharmaceuticals

What Are Epilepsy Clinical Trials?

Epilepsy is a relatively common central nervous system (neurological) disorder where the patient’s brain experiences abnormal activity.

The condition results in surges of electrical activity, which cause frequent and recurring seizures or periods when the behavior is unusual. Sufferers may experience strange sensations while sometimes losing awareness.

Clinical trials aim to identify the condition's prevalence, early detection, and improvements in treatment methods.

Why Is Epilepsy Being Studied Through Clinical Trials?

Epilepsy clinical trials are research studies that use human volunteers to collate information or test the efficacy of new developments. Epilepsy is the fourth most common form of neurological disorder, and 1.2% (3,4 million people) of the American population suffer from epilepsy. Clinic trials aim to understand the disease etiology, and help to address symptomatology.

What Are The Types of Treatments Available For Epilepsy?

Current treatment protocols include medication, surgery and teaching epileptic sufferers to identify the signs of an upcoming event.

Many of the current trials are focused on enabling early diagnosis of the condition.

Examples Of Current Epilepsy Treatment Trials

Mirna223 And HMGB1 As Apredictos For Drug Resistant Epilepsy

The trial seeks to diagnose drug-resistant Epilepsy (DRE) by identifying the circulating biomarkers for DRE. If successful, it will provide an early diagnosis and an indication of the prognosis, which will give greater insight into the correct treatment choice.

What Are Some Recent Breakthrough Clinical Trials For Epilepsy?

Epilepsy clinical trials look to help prevent, detect, and treat Epilepsy.

2019: New medication to treat drug-resistant Epilepsy – 40% of people with Epilepsy have drug-resistant Epilepsy (DRE), which then requires surgical intervention. A trial has been completed testing a new drug called “cenobamate ."The trial results showed marked improvements for the two highest-dose groups in particular. Participants who took either the 200mg or 400mg doses had 55% fewer seizures overall, with 21% stopping seizures altogether.

2021: Testing an inexpensive anti-seizure medication on Alzheimer patients with Epilepsy – A trial was conducted to test the effect of the anti-seizure medication “levetiracetam." Unmedicated Alzheimer patients who suffer from silent epileptic activity in their brains experience a faster decline in cognitive function. The drug was administered twice a day and showed trends toward improvement in cognitive function,

Who Are Some Of The Key Opinion Leaders / Researchers In Epilepsy Research?

Dr. Chris Dulla is a Tufts University School of Medicine and Neuroscience Associate Professor.

Dr. John W Swann, Ph. D. Professor of Pediatrics-Neurology Baylor College of Medicine.

Dr. Jeffrey L Noebels, M.D., Ph.D. Professor Neurology, Neuroscience, and Molecular and Human Genetics

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 12th, 2021

Last Reviewed: October 22nd, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.