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Brain Stimulation

Frontal Stimulation for Working Memory

N/A

Waitlist Available

Led By Flavio Frohlich, PhD

Research Sponsored by University of North Carolina, Chapel Hill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

History of medically intractable epilepsy

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the 1- to 1.5-hour test at baseline and stimulation session conducted over a 1 to 2 day period

Awards & highlights

Study Summary

This trial aims to understand how brain waves affect memory control. The study will involve patients with epilepsy who had electrodes implanted previously. A total of 50 participants will take part in the study. They will

Who is the study for?

This trial is for patients with medically intractable epilepsy who have had electrodes implanted for monitoring. They must be able to consent, speak English, and not have other major neurological illnesses, severe cognitive or psychiatric conditions, substance abuse issues, or any risk factors that could affect their participation as judged by the investigator.Check my eligibility

What is being tested?

The study tests how different types of brain stimulation (theta and alpha oscillations) affect working memory control. Participants will undergo direct cortical stimulation while performing a cognitive task to see which stimulation methods best modulate brain activity.See study design

What are the potential side effects?

While specific side effects are not listed here, direct cortical stimulation can potentially cause discomfort at the electrode site, headaches, seizures during the procedure (in those predisposed), and transient changes in mood or cognition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have epilepsy that doesn't respond to treatment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the 1- to 1.5-hour test at baseline and stimulation session conducted over a 1 to 2 day period

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the 1- to 1.5-hour test at baseline and stimulation session conducted over a 1 to 2 day period

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the 1- to 1.5-hour test at baseline and stimulation session conducted over a 1 to 2 day period for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Working Memory Task Performance - Pashler's working memory capacity metric (k)

Change in Working Memory Task Performance - Reaction Time

Intracranial EEG Multi-taper fft

+1 more

Secondary outcome measures

Intracranial EEG Granger causality

Intracranial EEG Wavelets

Intracranial EEG phase locking

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Frontal StimulationActive Control3 Interventions

Direct Cortical Stimulation (DCS) in alpha and theta frequencies is applied through electrodes located in the frontal cortex.

Group II: Frontal Parietal StimulationPlacebo Group3 Interventions

Direct Cortical Stimulation (DCS) in in-phase and anti-phase theta frequencies is applied through electrodes located in the frontal and parietal cortex.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor

1,508 Previous Clinical Trials

4,190,932 Total Patients Enrolled

2 Trials studying Working Memory

34 Patients Enrolled for Working Memory

National Institute of Mental Health (NIMH)NIH

2,785 Previous Clinical Trials

2,689,706 Total Patients Enrolled

2 Trials studying Working Memory

46 Patients Enrolled for Working Memory

Flavio Frohlich, PhDPrincipal InvestigatorUNC Chapel Hill

19 Previous Clinical Trials

669 Total Patients Enrolled

2 Trials studying Working Memory

34 Patients Enrolled for Working Memory

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals currently eligible to participate in this ongoing clinical trial?

"As per the details on clinicaltrials.gov, recruitment for this investigation has ceased. The study was first listed on February 1st, 2024 and most recently revised on the same date. Despite this trial no longer accepting participants, there are currently 246 other trials actively seeking candidates for enrollment."

Answered by AI

Does this clinical trial allow individuals older than 70 years to participate as patients?

"Candidates must be at least 18 years old but no more than 80 years old to qualify for this research study."

Answered by AI

Which individuals meet the eligibility criteria to enroll in this research study?

"Individuals aged between 18 and 80 with intact working memory are eligible to participate in this research. The study aims to enroll a maximum of 50 individuals."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Causal Role of Top-Down Theta Oscillations in Prioritization

2024. "Causal Role of Top-Down Theta Oscillations in Prioritization". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06252532.

All > Epilepsy