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Behavioural Intervention

Image Exposure Arm for Post-Traumatic Stress Disorder (PTSD Trial)

N/A

Recruiting

Led By Bradley M Peterson, MD

Research Sponsored by Children's Hospital Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patient Population: Males and females ages 18-50

Healthy Population: Males and Females, ages 18-50

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days 3-7

Awards & highlights

PTSD Trial Summary

This trial is trying to develop a new treatment for combat veterans with PTSD. They want to know how exposure to combat-related images affects the brain and how participants feel about it. They will compare veterans with

Who is the study for?

This trial is for U.S. combat veterans who have PTSD. Participants will be exposed to combat-related images and must be able to undergo an fMRI scan. The study aims to include those directly affected by traumatic stress disorders, specifically from their military service.Check my eligibility

What is being tested?

The trial tests a new behavioral treatment involving very brief exposure to combat images compared with visible exposure, assessing its effects on brain activity and subjective fear ratings in participants with PTSD versus healthy controls.See study design

What are the potential side effects?

Since this is a psychological study involving viewing images, side effects may include temporary increases in stress or anxiety levels due to the exposure of potentially triggering content.

PTSD Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old.

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I am between 18 and 50 years old and healthy.

PTSD Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days 3-7

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days 3-7

This trial's timeline: 3 weeks for screening, Varies for treatment, and days 3-7 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Mean Activation of Frontostriatal and Prefrontal Brain Regions to combat stimuli in PTSD

Secondary outcome measures

Fear induced by exposure to combat stimuli in PTSD in healthy participants as measured by fear scale

Fear induced by exposure to combat stimuli in PTSD in veteran group as measured by fear scale

PTSD Trial Design

1Treatment groups

Experimental Treatment

Group I: Image Exposure ArmExperimental Treatment1 Intervention

This within-subjects design study will have all participants view three types of exposure during fMRI scanning: VBE to combat images, VBE to masked everyday scenes (control), and conscious visible exposure to the same images (control).

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Children's Hospital Los AngelesLead Sponsor

232 Previous Clinical Trials

5,076,444 Total Patients Enrolled

Bradley M Peterson, MDPrincipal InvestigatorChildren's Hospital Los Angeles

1 Previous Clinical Trials

8 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this clinical trial inclusive of individuals who have reached the age of 18?

"This research project is seeking individuals who have reached the age of consent but are under 50 years old."

Answered by AI

How large is the participant pool in this medical study?

"Affirmative. The information provided on clinicaltrials.gov indicates that this investigation is actively seeking participants. It was initially posted on January 1, 2024, and most recently updated on January 18, 2024. A total of 80 subjects will be admitted to a single site for the trial."

Answered by AI

Are there ongoing efforts to actively enroll participants for this medical study?

"Indeed, the information available on clinicaltrials.gov indicates that this trial is actively seeking participants. The trial was initially posted on January 1st, 2024 and last updated on January 18th, 2024. The study aims to recruit a total of 80 patients from one specific site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

Bradley Peterson 2024. "The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06218381.

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