4-Aminopyridine for Burns
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a treatment called 4-Aminopyridine to determine if it can accelerate burn healing. Researchers aim to assess its effectiveness in improving healing for individuals with second-degree burns, which are serious but do not penetrate the entire skin. Participants will take either a 4-Aminopyridine capsule or a placebo every 12 hours. This trial may suit adults with recent second-degree burns covering a small skin area who can attend regular follow-up appointments. As a Phase 2 trial, the research focuses on evaluating the treatment's effectiveness in an initial, smaller group of people.
Do I have to stop taking my current medications for the trial?
Yes, you will need to stop taking certain medications. Specifically, you cannot participate if you are currently using aminopyridine medications or organic cat-ion transporter 2 (OCT2) inhibitors like Cimetidine.
Is there any evidence suggesting that 4-Aminopyridine is likely to be safe for humans?
Research has shown that 4-Aminopyridine (4-AP), also known as dalfampridine, is usually safe at recommended doses. Studies have identified common side effects such as dizziness and urinary tract infections. Reports indicate that higher doses can cause symptoms like shaking and increased nervousness. However, the risk of serious heart problems, such as an irregular heartbeat, remains low at normal doses.
The FDA has already approved this treatment for other uses, such as improving walking in people with multiple sclerosis, indicating its safety when used correctly. Nonetheless, anyone considering joining a clinical trial should discuss potential risks with their doctor.12345Why do researchers think this study treatment might be promising?
Most treatments for burns focus on wound care and infection prevention, but 4-aminopyridine offers a unique approach by potentially enhancing nerve function and facilitating healing. Unlike standard care options, which often involve topical antibiotics and dressings, 4-aminopyridine is an oral medication that may accelerate recovery by improving cellular communication. Researchers are excited about this treatment because its novel mechanism—blocking potassium channels—could lead to faster and more effective healing than current methods.
What evidence suggests that 4-Aminopyridine might be an effective treatment for burns?
Research has shown that 4-Aminopyridine (4-AP), which participants in this trial may receive, can accelerate burn healing. Studies indicate that 4-AP reduces swelling, aiding in better wound healing. It also reduces inflammation, which is beneficial after a burn. Originally approved for multiple sclerosis, 4-AP has demonstrated an ability to speed up burn wound healing. These findings suggest that 4-AP could be a promising treatment for enhancing burn recovery.26789
Who Is on the Research Team?
John Elfar, MD
Principal Investigator
University of Arizona
Are You a Good Fit for This Trial?
This trial is for patients who have suffered from traumatic skin burns and are seeking improved healing treatments. The specific eligibility criteria to participate in the trial are not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 4-aminopyridine or placebo to evaluate its effect on burn wound healing
Follow-up
Participants are monitored for scar sensitivity, scar formation, and healing rate using POSAS and imaging
What Are the Treatments Tested in This Trial?
Interventions
- 4-Aminopyridine
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
John Elfar
Lead Sponsor