60 Participants Needed

Collaborative Care for Anxiety and Depression in Epilepsy

HM
JH
LP
Overseen ByLauren P Richmond
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 3 JurisdictionsThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.

Do I have to stop taking my current medications for this trial?

The trial protocol does not specify if you need to stop taking your current medications. However, if you are currently prescribed 2 or more psychotropic medications for psychiatric reasons and are not considered a good candidate for collaborative care, you may be excluded from the trial.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

What safety data exists for Collaborative Care for anxiety and depression in epilepsy?

The provided research does not directly address safety data for Collaborative Care in epilepsy. However, it discusses the effectiveness and implementation of Collaborative Care models for mental health conditions like depression, anxiety, and bipolar disorder, often in conjunction with other physical health conditions. These studies suggest that Collaborative Care is effective in managing mental health conditions, but specific safety data for epilepsy is not mentioned.12345

Is collaborative care safe for humans?

Collaborative care, which involves a team of health professionals working together, has been studied for various conditions like depression, anxiety, and bipolar disorder. While the focus is often on effectiveness, the model generally involves standard medical practices and monitoring, suggesting it is safe for humans.12345

Is Collaborative Care a promising treatment for anxiety and depression in people with epilepsy?

Yes, Collaborative Care is promising because it involves a team of health professionals working together to address both epilepsy and mental health issues like anxiety and depression. This approach can improve the quality of care and support for patients, making it easier to manage their conditions.678910

How is the Collaborative Care treatment for anxiety and depression in epilepsy different from other treatments?

Collaborative Care is unique because it involves a team-based approach that integrates psychological interventions into epilepsy care, addressing both mental health and epilepsy together, unlike traditional treatments that may focus on these issues separately.678910

What data supports the idea that Collaborative Care for Anxiety and Depression in Epilepsy is an effective treatment?

The available research shows that Collaborative Care is effective in improving outcomes for people with depression and anxiety. For example, one study highlights that this approach has been successful in managing depression in patients with other health conditions like diabetes and heart disease. Another review found that Collaborative Care significantly benefits patients with depression by improving the quality of care through better coordination between healthcare providers. Although specific data on its use for epilepsy is limited, these findings suggest that Collaborative Care can be a promising treatment for anxiety and depression in various contexts.1112131415

What data supports the effectiveness of the treatment Collaborative Care for Anxiety and Depression in Epilepsy?

Collaborative care has been shown to improve outcomes for patients with depression and anxiety by enhancing collaboration between primary care providers and mental health specialists, leading to better diagnosis and management of these conditions. Studies have demonstrated its effectiveness in managing depression alongside other chronic conditions like diabetes and cardiovascular disease, suggesting potential benefits for patients with epilepsy as well.1112131415

Who Is on the Research Team?

HM

Heidi M. Munger Clary, MD, MPH

Principal Investigator

Wake Forest University Health Sciences

Are You a Good Fit for This Trial?

This trial is for adults over 18 with epilepsy who also experience anxiety or depression. They must be getting care at Atrium Health Wake Forest Baptist and willing to follow the study's procedures. People with a life expectancy under 6 months, those in another study, or with cognitive issues that prevent them from reporting their mental health status are excluded.

Inclusion Criteria

Stated willingness to comply with all study procedures
I experience symptoms of anxiety or depression.
Receiving clinical neurological care at Atrium Health Wake Forest Baptist
See 2 more

Exclusion Criteria

Current participation in another treatment or intervention study
Cognitive limitations precluding completion of Anxiety and Depression self-report instruments
Not a good candidate for collaborative care due to: Active ongoing treatment by a psychiatrist; Active suicidal ideation; Unstable drug or alcohol abuse; history of past suicide attempt and: currently prescribed 2 or more psychotropic medications for psychiatric indication OR receiving ongoing psychotherapy OR has seen a psychiatrist in the past year
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a 24-week neurology-based collaborative care intervention

24 weeks
Regular visits with care manager/social worker and psychiatrist

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Collaborative Care
  • Usual Neurology Care
Trial Overview The trial compares a collaborative care approach versus usual neurology care for managing anxiety and depression in people with epilepsy. It lasts for 24 weeks and involves randomly placing participants into one of these two groups.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: collaborative careExperimental Treatment1 Intervention
Group II: usual neurology careActive Control1 Intervention

Collaborative Care is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Collaborative Care for:
🇪🇺
Approved in European Union as Integrated Care for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

Wake Forest University Health Sciences

Lead Sponsor

Trials
1,432
Recruited
2,506,000+

Published Research Related to This Trial

The ADAPT program is a new collaborative care model aimed at improving outcomes for patients with mild to moderate-severe depression and anxiety, utilizing evidence-based practices like measurement-based care and accurate diagnosis.
This study will compare the effectiveness of the ADAPT program against traditional outpatient psychiatric care, potentially providing valuable insights into the implementation and outcomes of collaborative care in a large health system.
Evaluating Implementation and Outcomes of the Achieving Depression and Anxiety Patient-Centered Treatment Collaborative Care Program in a Large, Integrated Health Care System: A Mixed Methods Observational Study Protocol.Ridout, KK., Ridout, SJ., Alavi, M., et al.[2023]
The integrated collaborative care model, which included low-intensity psychological therapy and support from practice nurses, led to a modest reduction in depression symptoms among 387 patients with chronic physical conditions, achieving a mean score reduction of 0.23 on the SCL-D13 scale.
Patients receiving collaborative care reported better self-management of their conditions and higher satisfaction with their care, although there were no significant differences in overall quality of life or disability compared to usual care.
Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease.Coventry, P., Lovell, K., Dickens, C., et al.[2022]
Collaborative care models significantly improve depression management, showing a standardized mean difference of 0.34 in depression symptoms and enhancing treatment adherence and response rates in various populations.
The systematic review of 69 studies indicates that these models not only improve clinical outcomes like remission and recovery from symptoms but also enhance patient satisfaction and quality of life, demonstrating their effectiveness across different healthcare settings.
Collaborative care to improve the management of depressive disorders: a community guide systematic review and meta-analysis.Thota, AB., Sipe, TA., Byard, GJ., et al.[2022]

Citations

Evaluating Implementation and Outcomes of the Achieving Depression and Anxiety Patient-Centered Treatment Collaborative Care Program in a Large, Integrated Health Care System: A Mixed Methods Observational Study Protocol. [2023]
Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease. [2022]
Collaborative care to improve the management of depressive disorders: a community guide systematic review and meta-analysis. [2022]
Enablers and barriers to implementing collaborative care for anxiety and depression: a systematic qualitative review. [2022]
Long-term Effects of a Collaborative Care Model on Metabolic Outcomes and Depressive Symptoms: 36-Month Outcomes from the INDEPENDENT Intervention. [2023]
Implementation Barriers and Experiences of Eligible Patients Who Failed to Enroll in Collaborative Care for Depression and Anxiety. [2023]
Association Between Chronic Physical Conditions and the Effectiveness of Collaborative Care for Depression: An Individual Participant Data Meta-analysis. [2022]
Enhancing the scalability of the collaborative care model for depression using mobile technology. [2021]
Collaborative mental health and primary care for bipolar disorder. [2022]
10.United Statespubmed.ncbi.nlm.nih.gov
Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial. [2022]
Seizures as a Struggle between Life and Death: An Existential Approach to the Psychosocial Impact of Seizures in Candidates for Epilepsy Surgery. [2023]
Using machine learning approach to predict depression and anxiety among patients with epilepsy in China: A cross-sectional study. [2023]
13.United Statespubmed.ncbi.nlm.nih.gov
Managing depression and anxiety in patients with epilepsy in eastern China: A survey of epilepsy health professionals in Zhejiang Province. [2022]
14.United Statespubmed.ncbi.nlm.nih.gov
Screening for Depression and Anxiety in Epilepsy. [2017]
[Multi-professional epilepsy teams including psychiatric expertise]. [2019]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security