Sci Clinical Trials
spinal cord injury studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect sci clinical trial.
Condition
Spinal Cord Injury
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Clinical Trials
Sci Clinical Trials
Phase-Based Estimates
1
Effectiveness
1
Safety
Electrophysiology Assessment - Reticulospinal Tract
for Spinal Cord Injuries
Saint Louis, MO
Any Age
All Sexes
Waitlist Available
Saint Louis, MO
Any Age
All Sexes
Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).
Phase-Based Estimates
1
Effectiveness
1
Safety
Delayed FES
for Wounds
Edmonton, Canada
18+
All Sexes
Recruiting
Edmonton, Canada
18+
All Sexes
Spinal cord injury (SCI) is a devastating condition that often leads to paralysis and multiple health problems such as muscle wasting, bone loss and spasticity. Despite the paralysis, functional electrical stimulation (FES) on the skin surface muscles may produce muscle contractions. People who have had an SCI for a long time (chronic SCI) already use FES cycling to exercise, and it is known that it can reverse muscle atrophy and has a wide range of health benefits. Furthermore, animal research suggests that starting exercise training early after new SCI may promote spinal cord recovery. However, not much is known about early FES cycling in humans. Therefore, the investigators propose to study if early FES cycling could prevent muscle wasting, pain or spasticity, and help with spinal cord recovery. The study will recruit 36 participants with a new, acute SCI, between 14 and 21 days after their injury into 3 groups. An Early-FES group starts FES cycling early after injury (between 14 and 21 days after injury), and for a duration of 6 months. A Delayed-FES group starts FES cycling 3 months after enrolling in the study, and for a duration of 3 months. A Control group does not perform FES cycling. This pilot study will allow us to study if early FES cycling, in addition to normal care, has greater benefits on the preservation and recovery of the leg muscles and spinal cord function than delayed FES cycling or standard care only. The results of this pilot study may lead to the development of a larger study with early FES cycling after new SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
High Intensity Interval Exercise Training Group
for Spinal Cord Injuries
Fort Smith, AR
18+
All Sexes
Recruiting
Locally Advanced
Fort Smith, AR
18+
All Sexes
Functional Interval Training for People with Spinal Cord Injury and Their Care Partners (SCI-FIT) aims to address barriers to physical activity for people with spinal cord injury and their care partners. This research study provides free, twice weekly group-based, adaptable exercise classes for people with spinal cord injury and their care partners.
Phase-Based Estimates
1
Effectiveness
1
Safety
Istradefylline
for Myelopathy
Cambridge, MA
18+
All Sexes
Phase 1 & 2
Waitlist Available
Cambridge, MA
18+
All Sexes
Breathing brief, moderate bouts of low oxygen trigger (low oxygen therapy, LOT) spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new experiences), and improve walking after spinal cord injury (SCI). The greatest improvements in walking ability occur when LOT is administered prior to skill-based walking practice (WALK). However, the enduring benefits of LOT on walking recovery may be undermined by the accumulation of LOT-induced increase in extracellular adenosine. The goal of the study is to understand the extent to which istradefylline (adenosine 2a receptor antagonist) may limit the competing mechanisms of adenosine on LOT-induced walking recovery following SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
NMES-BCI
for Wounds
Austin, TX
18+
All Sexes
Recruiting
Austin, TX
18+
All Sexes
A brain-computer interface (BCI) decodes users' behavioral intentions or mental states directly from their brain activity, thus allowing operation of devices without requiring any overt motor action. One major modality for BCI control is based on motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement without actually performing it. MI-based BCIs translate motor intents into control commands for external devices. A major challenge in such BCIs is differentiating MI patterns corresponding to fine hand movements of the same limb from non-invasive EEG recordings with low spatial resolution since the cortical sources responsible for these movements are overlapping. In this study, the investigators hypothesize that neuromuscular electrical stimulation (NMES) applied contingent to the voluntary activation of the primary motor cortex through MI can help differentiate patterns of activity associated with different hand movements of the same limb by consistently recruiting the separate neural pathways associated with each of the movements within a closed-loop BCI setup. This is expected to be associated with neuroplastic changes at the cortical or corticospinal levels.
Phase-Based Estimates
1
Effectiveness
1
Safety
Non-invasive Pairing Of Cortical And Spinal Stimulation
for Spinal Cord Diseases
New York, NY
18+
All Sexes
Recruiting
New York, NY
18+
All Sexes
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury. The proposed study will advance understanding of SCAP, which is critical to its effective translation to human therapy. The purpose of the study is to: Determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation. Improve our understanding of the spinal cord and how it produces movement. Determine whether spinal surgery to relieve pressure on the spinal cord can improve its function. Aim 1 is designed to advance mechanistic understanding of spinal cord associative plasticity (SCAP). Aim 2 will determine whether SCAP increases spinal cord excitability after the period of repetitive pairing. In rats, SCAP augments muscle activation for hours after just 5 minutes of paired stimuli. Whereas Aims 1 and 2 focused on the effects of paired stimulation in the context of uninjured spinal cord, Aim 3 assesses whether paired stimulation can be effective across injured cord segments. Aim 3 will incorporate the experiments from Aim 1 and 2 but in people with SCI, either traumatic or pre-operative patients with myelopathy in non-invasive experiments, or targeting myelopathic segments in intraoperative segments.
Phase-Based Estimates
1
Effectiveness
1
Safety
User-controlled FES System
for Spinal Cord Injuries
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The objective of this study is to advance personalized, portable, and non-invasive hand-grasp neuro-orthoses that restore naturalistic grasp functions for those with tetraplegia due to spinal cord injury (SCI), designed around their needs and preferences.
Phase-Based Estimates
1
Effectiveness
1
Safety
Ekso
for Spinal Cord Injuries
Houston, TX
18+
All Sexes
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether it is possible to reach high cardiovascular intensity training parameters while walking in a wearable robotic exoskeleton.
Phase-Based Estimates
1
Effectiveness
1
Safety
Passive Heat Stress
for Inflammation
San Antonio, TX
18 - 65
All Sexes
Phase < 1
Waitlist Available
San Antonio, TX
18 - 65
All Sexes
This study is evaluating whether repeated bouts of passive heating can improve heart disease risk factors in persons with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Non-invasive, Surface Electrical Stimulation Device, DS5 Digitimer
for Spinal Cord Injuries
Dayton, OH
18+
All Sexes
Waitlist Available
Dayton, OH
18+
All Sexes
This study is evaluating whether electrical stimulation of the abdomen may help improve bowel function for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Insertion Of Intraspinal Pressure Monitor
for Spinal Cord Injuries
Winnipeg, Canada
18+
All Sexes
Recruiting
Locally Advanced
Winnipeg, Canada
18+
All Sexes
This study is evaluating whether intraspinal pressure monitoring can be used to evaluate spinal cord perfusion pressure and spinal cord reserve capacity.
Phase-Based Estimates
1
Effectiveness
1
Safety
WebEx Physical Activity Program
for Spinal Cord Injuries
London, Canada
18+
All Sexes
Recruiting
London, Canada
18+
All Sexes
During the current COVID-19 pandemic many spinal cord injury (SCI) rehabilitation services are limited to emergency management, leaving those living in the community without access to services. Unfortunately, this can lead to negative effects including increase in emotional distress, feelings of isolation, and decreased activity engagement. Due to their limited mobility and greater likelihood of respiratory illness it is imperative to provide alternative forms of activity engagement to reduce their risk for secondary complications. Physical activity has been demonstrate to have numerous benefits for individuals with SCI ranging from enhanced health through prevention of secondary complications to improved subjective well-being. The current study proposes to provide an online physical activity program through web-based videoconferencing to person with SCI to improve overall wellbeing and activity engagement. The program will consist of six weeks of twice-weekly, 45-minute sessions in which an experienced fitness instructor (i.e., wheelchair aerobics) with lived experience and a Kinesiology graduate student will lead online sessions. The sessions will be comprised of a 10-minute warm-up phase, a 25-minute aerobic phase and a 10-minute cool-down phase that will incorporate upper-extremity flexibility exercises and guided meditation. In all cases, remote (i.e., in-home) participant monitoring of physiological signals will be conducted by the instructor to ensure safety of participants. Once the program has been completed, participants will be asked to complete self-report questionnaires related to acceptability, feasibility, and limited effectiveness. Participants will also be asked to complete a brief semi-structured interview examining barriers and facilitators of the program. Participant feedback from the interviews will be used to further develop of the program to meet the needs of the population and develop sustainable approaches for access to care in the community setting through collaborations with community partners (SCI Ontario, National SCI Alliance, Ontario Neurotrauma Foundation). Ultimately, the proposed project aims to improve overall wellbeing and access to health care service for those with SCI during the COVID-19 quarantine.
Phase-Based Estimates
1
Effectiveness
1
Safety
Stimulation For Trunk And Core Without Stand
for Spinal Cord Injuries
Louisville, KY
18+
All Sexes
Recruiting
Louisville, KY
18+
All Sexes
This study is evaluating whether a spinal cord stimulator may help improve bowel function in individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
2
Safety
Gentamicin Sulfate
for Urinary Tract Infections
Louisville, KY
18+
All Sexes
Phase 2
Waitlist Available
1 Prior Treatment
Louisville, KY
18+
All Sexes
This study is evaluating whether gentamicin bladder instillations reduce the rate of symptomatic UTIs in adults with chronic spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Low Level Laser Therapy
for Dyschezia
Hamilton, Canada
Any Age
All Sexes
Recruiting
Hamilton, Canada
Any Age
All Sexes
This study is evaluating whether low level laser therapy will do more good than harm for patients with severe chronic refractory constipation.
Phase-Based Estimates
1
Effectiveness
1
Safety
Hypoxia
for SCI
Hines, IL
18+
All Sexes
Phase < 1
Recruiting
Hines, IL
18+
All Sexes
This study is evaluating whether a combination of a specific type of breathing and physical therapy may help improve upper limb function for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Paraspinal
for Spinal Cord Injuries
Coral Springs, FL
18+
All Sexes
Recruiting
Class II
Coral Springs, FL
18+
All Sexes
This study is evaluating whether a combination of stem cell injections and virtual reality may help individuals with spinal cord injuries.
Phase-Based Estimates
1
Effectiveness
1
Safety
PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
for Acute Spinal Cord Injury (SCI)
Charlotte, NC
18+
All Sexes
Recruiting
Charlotte, NC
18+
All Sexes
The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury. Within 12-weeks of injury, participants will either receive an implanted nerve stimulator (like a pace-maker for the bladder) or standard care for neurogenic bladder. Patients will be assigned to one of these groups at random and followed for one year. The hypothesis is that early stimulation of the nerves will help prevent the development of neurogenic bladder.
Phase-Based Estimates
1
Effectiveness
1
Safety
Walking
for Spinal Cord Injuries
Cambridge, MA
18+
All Sexes
Recruiting
Cambridge, MA
18+
All Sexes
This study is evaluating whether breathing low oxygen levels may help restore walking and leg strength in individuals who have sustained a spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Neural Prosthetic System 2 (NPS2)
for Quadriplegia
Downey, CA
18+
All Sexes
Recruiting
Downey, CA
18+
All Sexes
This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts along with sensory feedback. Development of a brain-machine interface is very difficult and currently only limited technology exists in this area of neuroscience. Other studies have shown that people with high spinal cord injury still have intact brain areas capable of planning movements and grasps, but are not able to execute the movement plans. The device in this study involves implanting very fine recording electrodes into areas of the brain that are known to create arm movement plans and provide hand grasping information and sense feeling in the hand and fingers. These movement and grasp plans would then normally be sent to other regions of the brain to execute the actual movements. By tying into those pathways and sending the movement plan signals to a computer instead, the investigators can translate the movement plans into actual movements by a computer cursor or robotic limb. A key part of this study is to electrically stimulate the brain by introducing a small amount of electrical current into the electrodes in the sensory area of the brain. This will result in the sensation of touch in the hand and/or fingers. This stimulation to the brain will occur when the robotic limb touches the object, thereby allowing the brain to "feel" what the robotic arm is touching. The device being used in this study is called the Neuroport Array and is surgically implanted in the brain. This device and the implantation procedure are experimental which means that it has not been approved by the Food and Drug Administration (FDA). One Neuroport Array consists of a small grid of electrodes that will be implanted in brain tissue and a small cable that runs from the electrode grid to a small hourglass-shaped pedestal. This pedestal is designed to be attached to the skull and protrude through the scalp to allow for connection with the computer equipment. The top portion of the pedestal has a protective cover that will be in place when the pedestal is not in use. The top of this pedestal and its protective cover will be visible on the outside of the head. Three Neuroport Arrays and pedestals will be implanted in this study so three of these protective covers will be visible outside of the head. It will be possible to cover these exposed portions of the device with a hat or scarf. The investigators hope to learn how safe and effective the Neuroport array plus stimulation is in controlling computer generated images and real world objects, such as a robotic arm, using imagined movements of the arms and hands.
Phase-Based Estimates
1
Effectiveness
1
Safety
Neural Communication System
for Paralysis
Los Angeles, CA
18+
All Sexes
Recruiting
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a brain chip may help individuals with severe paralysis communicate.
Phase-Based Estimates
1
Effectiveness
1
Safety
The VSail-Access Simulator
for Spinal Cord Injuries
Baltimore, MD
18 - 65
All Sexes
Phase 1 & 2
Recruiting
Baltimore, MD
18 - 65
All Sexes
This study is evaluating whether a sailing simulator may help improve quality of life for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
2
Safety
Notification EMA
for Spinal Cord Injuries
Philadelphia, PA
18+
All Sexes
Phase 2
Waitlist Available
Philadelphia, PA
18+
All Sexes
The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate the integration of a JITAI with a web-based physical activity intervention program. We hypothesize that the integration of web-based physical activity intervention program with JITAI will result in significantly higher physical activity levels compared to the standard web-based physical activity intervention program alone. A secondary objective of this study is to extend existing algorithms that use commercial wearable technology to robustly detect physical activity behaviors to facilitate the delivery of tailored just-in-time actionable feedback and physical activity recommendations for individuals with SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
LIFT System
for Spinal Cord Injuries
Atlanta, GA
18+
All Sexes
Recruiting
Atlanta, GA
18+
All Sexes
The LIFT Home Study is an observational, single-arm study designed to assess the safety of non-invasive electrical spinal stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in people with chronic tetraplegia.
Phase-Based Estimates
1
Effectiveness
1
Safety
Web-Based Support And Education Program 2
for Spinal Cord Injuries
West Orange, NJ
18+
All Sexes
Recruiting
West Orange, NJ
18+
All Sexes
This study is evaluating whether two different types of education and support programs for partner caregivers of people with spinal cord injury (SCI) are equally effective.
Phase-Based Estimates
1
Effectiveness
1
Safety
Leg Ergometer
for Spinal Cord Injuries
Montréal, Canada
18+
All Sexes
Recruiting
Montréal, Canada
18+
All Sexes
This study is evaluating whether a set of activities can improve recovery after a spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
LIFT System
for Spinal Cord Injuries
Philadelphia, PA
18+
All Sexes
Recruiting
Philadelphia, PA
18+
All Sexes
This study is evaluating whether a spinal cord stimulator may help improve upper extremity function in individuals with chronic tetraplegia.
Phase-Based Estimates
1
Effectiveness
2
Safety
MT-3921
for Spinal Cord Injuries
Houston, TX
18+
All Sexes
Phase 2
Recruiting
Houston, TX
18+
All Sexes
The purpose of this study is to compare the efficacy and safety of intravenous (IV) infusions of MT-3921 to placebo in subjects with acute traumatic cervical spinal cord injury. Subjects meeting eligibility criteria will enter the 6-month double-blind period. Subjects will be randomized in a 2:1 ratio to receive MT-3921 or placebo in a double blind manner.
Phase-Based Estimates
1
Effectiveness
2
Safety
Locomotor Training
for Spinal Cord Injuries
Jacksonville, FL
18+
Male
Phase 2
Recruiting
Jacksonville, FL
18+
Male
This study is evaluating whether a combination of testosterone replacement therapy and walking training may help improve walking ability in individuals with incomplete spinal cord injury.
Phase-Based Estimates
1
Effectiveness
2
Safety
Noninvasive Ventilation (NIV)
for Wounds
Cambridge, MA
18 - 65
All Sexes
Phase 2
Recruiting
Cambridge, MA
18 - 65
All Sexes
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI). Functional Electrical Stimulation Row Training (FESRT) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. However, despite the potential for enhancing aerobic capacity by training the denervated leg skeletal muscle via hybrid FES exercise, the inability to increase ventilation beyond limits set by high level SCI restricts aerobic capacity. This research study will investigate two potential methods of improving ventilation in those with high-level SCI through a double-blind randomized trial. One method is non-invasive ventilation (NIV), which is an external breathing support machine. The second method is the use of Buspar, a drug, which has been used to treat respiratory dysfunction after SCI in rats and some human case reports. In this study, participants will engage in a 6-month FES row training program while receiving either NIV or shamNIV and Buspar or placebo, and under study tests to evaluate cardiopulmonary health and fitness.
Phase-Based Estimates
1
Effectiveness
1
Safety
Gait Training Performed In A Movement Amplification Environment
for Spinal Cord Injuries
Hines, IL
18+
All Sexes
Recruiting
Hines, IL
18+
All Sexes
This study is evaluating whether a new type of therapy may help improve balance for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Biostim-5 Transcutaneous Spinal Stimulator
for Spinal Cord Injuries
Louisville, KY
< 65
All Sexes
Recruiting
Louisville, KY
< 65
All Sexes
This study is evaluating whether a new therapy may help children with spinal cord injuries regain use of their arms and hands.
Phase-Based Estimates
1
Effectiveness
1
Safety
Biofeedback Training
for Quadriplegia
Englewood, CO
18+
All Sexes
Recruiting
Englewood, CO
18+
All Sexes
The purpose of this research is to test the feasibility of an intervention using biofeedback to treat stress and anxiety among individuals with tetraplegia. The expected duration of participation in this study is about 15 hours over the course of about 5 weeks. Participants will be randomly assigned to either a biofeedback training intervention or a control group. After completing questionnaires, participants will undergo physiological monitoring (measuring heart rate and breathing) at Craig Hospital. Those assigned to the biofeedback group will undergo 30 minutes of physiological monitoring while also participating in biofeedback training twice a week for 4 weeks (8 sessions) from home. Those assigned to the control group will undergo 30 minutes of physiological monitoring twice a week for 4 weeks (8 sessions) from home, but will not receive biofeedback training. Each session is expected to last 1-1.5 hours. Following each training session, participants will respond to questionnaires over the phone. It is hypothesized that the biofeedback intervention will demonstrate high feasibility and compared to those in the control group, participants who receive the biofeedback intervention will attain greater pre-post reductions in both physiological and self-reported stress.
Phase-Based Estimates
1
Effectiveness
1
Safety
Guided ICBT
for Spinal Cord Injuries
Regina, Canada
18+
All Sexes
Waitlist Available
Regina, Canada
18+
All Sexes
This study is evaluating whether a set of activities can improve anxiety and depression in people with SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
Enhanced Medical Rehabilitation (EMR)
for Spinal Cord Injuries
Chicago, IL
18+
All Sexes
Waitlist Available
Chicago, IL
18+
All Sexes
This study is evaluating whether a new intervention called Enhanced Medical Rehabilitation (EMR) can improve outcomes for people with spinal cord injury (SCI).
Phase-Based Estimates
1
Effectiveness
1
Safety
Telepsychology
for Depression
San Jose, CA
18+
All Sexes
Recruiting
San Jose, CA
18+
All Sexes
This study is evaluating whether a set of activities can improve mood in people with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
EnhanceWellness For Disability (EW-D)
for Disabilities Physical
Seattle, WA
18 - 65
All Sexes
Waitlist Available
Seattle, WA
18 - 65
All Sexes
This study is evaluating whether a specific intervention may help improve quality of life for individuals with physical disabilities.
Phase-Based Estimates
1
Effectiveness
1
Safety
Neuromuscular Electrical Stimulation
for Muscular Atrophy
Birmingham, AL
18 - 65
All Sexes
Recruiting
High Risk
Birmingham, AL
18 - 65
All Sexes
This study is evaluating whether a new type of electrical stimulation may help improve metabolism for individuals with spinal cord injury.
Phase-Based Estimates
3
Effectiveness
3
Safety
Supplemental Oxygen
for Spinal Cord Injuries
Detroit, MI
18+
All Sexes
Phase 4
Recruiting
Detroit, MI
18+
All Sexes
This study is evaluating whether a surgery to remove a portion of the spine may help reduce sleep apnea in individuals with a history of neck injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Electrophysiology Assessment Of Location
for Spinal Cord Injuries
Chicago, IL
18+
All Sexes
Recruiting
Chicago, IL
18+
All Sexes
This study is evaluating whether a new method of stimulating the brain may help restore motor function in individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Capsaicin 8% Patch
for Spinal Cord Injuries
San Antonio, TX
18+
All Sexes
Waitlist Available
San Antonio, TX
18+
All Sexes
This study is evaluating whether a patch containing capsaicin may help reduce pain for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Networked Neuroprosthetic System For Grasp And Trunk
for Spinal Cord Injuries
Cleveland, OH
Any Age
All Sexes
Recruiting
Grade III
Cleveland, OH
Any Age
All Sexes
This study is evaluating a new device that can help people with cervical spinal cord injury regain some function in their arms and hands.
Phase-Based Estimates
1
Effectiveness
1
Safety
Ekso Exoskeleton
for Spinal Cord Injuries
Chicago, IL
18+
All Sexes
Waitlist Available
Locally Advanced
Chicago, IL
18+
All Sexes
This study is evaluating whether the Ekso device can improve balance and walking ability in people with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Robotic Gait Training
for Spinal Cord Injuries
Dallas, TX
Any Age
All Sexes
Recruiting
Dallas, TX
Any Age
All Sexes
The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation
Phase-Based Estimates
1
Effectiveness
2
Safety
NMES
for Spinal Cord Injuries
Richmond, VA
18+
All Sexes
Phase 2 & 3
Recruiting
Richmond, VA
18+
All Sexes
This study is evaluating whether a combination of exercise and vitamin D supplementation can improve bone quality in people with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
ACCESS
for Spinal Cord Injuries
Richmond, VA
18+
All Sexes
Recruiting
Richmond, VA
18+
All Sexes
This study is evaluating whether a tailored program may help improve employment for veterans with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Cognitive Multisensory Therapy
for Spinal Cord Injuries
Minneapolis, MN
18+
All Sexes
Recruiting
Minneapolis, MN
18+
All Sexes
Many adults with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain. Available treatments, including opioids, are ineffective at eliminating this pain. Based on preliminary data from Dr Morse and from Dr Van de Winckel, we have demonstrated that brain areas that are important for body awareness and pain perception (parietal operculum, insula) have weaker brain connectivity in adults with spinal cord injury than in able-bodied healthy adults and that Cognitive Multisensory Rehabilitation (CMR) can restore these networks. This study uses a cross-over study for adults with SCI and a comparison of baseline outcomes in adults with SCI vs able-bodied healthy adults to address two aims: AIM 1: Determine baseline differences in resting-state and task-based fMRI activation and connectivity in adults with SCI compared to able-bodied healthy controls. AIM 2: Identify changes in brain activation and connectivity, as well as behavioral outcomes in pain and body awareness in adults with SCI after CMR versus standard of care.
Phase-Based Estimates
1
Effectiveness
1
Safety
SCI&U Online Health Coaching Program
for Spinal Cord Injuries
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a self-management program can improve self-management skills and reduce hospitalization rates in people with SCI.
Phase-Based Estimates
2
Effectiveness
3
Safety
Culturelle 10 Billion CFU Capsule (4 Doses)
for Spinal Cord Injuries
Washington, United States
18+
All Sexes
Phase 3
Recruiting
Washington, United States
18+
All Sexes
This study is evaluating whether a specific strain of bacteria may help reduce urinary symptoms for individuals with interstitial cystitis.
Phase-Based Estimates
1
Effectiveness
1
Safety
Functional Electrical Stimulation
for Hypotension, Orthostatic
Omaha, NE
18+
All Sexes
Waitlist Available
Omaha, NE
18+
All Sexes
This study is evaluating whether FES can be used to help people with OH secondary to SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
Spinal Cord Epidural Stimulation
for Autonomic Dysreflexia
Louisville, KY
18+
All Sexes
Recruiting
Louisville, KY
18+
All Sexes
This study is evaluating whether spinal cord epidural stimulation may help regulate cardiovascular function for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Transcutaneous Spinal Stimulation
for Spinal Cord Injuries
Louisville, KY
< 18
All Sexes
Recruiting
Louisville, KY
< 18
All Sexes
Paralysis of trunk muscles and the inability to sit upright is one of the major problems facing adults and children with spinal cord injury (SCI). Activity-based locomotor training has resulted in improved trunk control in children with spinal cord injury, though full recovery is not achieved in all children. Transcutaneous spinal stimulation' (TcStim), a stimulation applied over the skin to the sensory nerves and spinal cord, is a promising tool that may further enhance improvements to trunk control. The purpose of this study is to determine the feasibility (can we do it) and safety of Transcutaneous Stimulation (TcStim) in children with SCI to acutely improve sitting upright and when used with activity-based locomotor training (AB-LT). Thus, can we provide this therapy to children and do so safely examining a child's immediate response and cumulative response relative to safety and comfort. Eight participants in this study will sit as best they can with and without the stimulation (i.e. stimulation applied across the skin to the nerves entering the spinal cord and to the spinal cord) and their immediate response (safety, comfort, trunk position) recorded. Then, two participants will receive approximately 40 sessions of activity-based locomotor training in combination with the stimulation. Their cumulative response of stimulation (i.e. safety, comfort, feasibility) across time will be documented. Participation in this study may last up to 3 days for the 8 participants being observed for acute response to stimulation and up to 9 weeks for the participants being observed for cumulative response to training with stimulation. We will monitor the participants throughout the testing and training for their response to the stimulation (i.e. safety) and their comfort.
Phase-Based Estimates
1
Effectiveness
1
Safety
Active Remote Ischemic Conditioning
for Spinal Cord Injuries
Bronx, NY
18+
All Sexes
Recruiting
Bronx, NY
18+
All Sexes
This study is evaluating whether a blood pressure cuff on a different limb may help improve motor function for individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Hybrid Assistive Limb (HAL)
for Wounds
Jacksonville, FL
18+
All Sexes
Recruiting
Jacksonville, FL
18+
All Sexes
This study is evaluating whether a robotic device can help individuals with spinal cord injuries improve their walking ability.
Phase-Based Estimates
1
Effectiveness
1
Safety
ReInventing Yourself After SCI Structured Group CBT
for Wounds
Ann Arbor, MI
18+
All Sexes
Waitlist Available
Ann Arbor, MI
18+
All Sexes
The primary goal of this study is to conduct a multi-site RCT to evaluate the replicability and efficacy of the ReInventing Yourself after SCI intervention in improving health and function outcomes for persons with spinal cord injury (SCI). A total of 252 participants will be randomized to one of three research arms: 1) Group treatment plus workbook (Group), 2) individual self-study through YouTube video plus workbook (Indiv), and 3) no treatment, no workbook (Control). Participants randomized to the Group arm will attend 6 virtual weekly group sessions led by a pair of group facilitators and will utilize the study workbook. Indiv arm participants will receive the workbook and will be instructed to independently access YouTube videos of the group session content. Control arm participants will not receive any intervention during the 6 week period. Participants in all three arms will be assessed at identical time points throughout the study: baseline, 6 weeks, 14 weeks, 22 weeks, 30 weeks, and 46 weeks. It is hypothesized that individuals in the Group intervention arm will show greater improvements after the six week intervention in SCI-specific and general self-efficacy, emotional well-being, increased societal participation, less depressive and anxiety symptomatology, and improved resilience than participants in the Indiv and Control arms.
Phase-Based Estimates
1
Effectiveness
1
Safety
Autologous, Adipose Derived Mesenchymal Stem Cells
for Spinal Cord Injuries
Rochester, MN
18+
All Sexes
Phase 1
Waitlist Available
Rochester, MN
18+
All Sexes
This study is evaluating whether mesenchymal stem cells can be safely administered into the cerebrospinal fluid of patients with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Mobile Application ("app")
for Spinal Cord Injuries
Vancouver, Canada
18+
All Sexes
Waitlist Available
Vancouver, Canada
18+
All Sexes
The goal of our study is to evaluate the use of a self-management application ("app") that the investigators have developed to help facilitate self-management among individuals with SCI who live in the community. The main purpose is to create and fulfill individual self-management goals. Other purposes include improving self-management and health conditions related to SCI. During the initial phase, participants (SCI clinicians and patients with SCI) reported positive usage of the self-management app and all agreed it would benefit people with SCI. With the widespread use of portable electronic devices, an opportunity exists to help patients and informal caregivers on the journey from rehabilitation to integration back into the community. The investigators will use a randomized controlled trial (randomly putting participants into two groups), including both surveys and interviews. The study will involve the use of the app that focuses on the self-management of SCI, along with five to six in-person or telephone meetings over a three-month period. Our proposal is original in that it will be one of the few randomized control trials for e-health interventions for self-care management for those with SCI. The overall goals of the study is to develop an affordable self-management app that can be used to encourage self-management in people living with SCI. This app would be used along with other health problem specific apps that are more detailed and expensive, while helping participants to manage their long-term health problems related to their SCI in an easily usable and affordable form.
Phase-Based Estimates
3
Effectiveness
3
Safety
Denosumab (Prolia)
for Wounds
West Orange, NJ
18+
All Sexes
Phase 4
Recruiting
West Orange, NJ
18+
All Sexes
This study is evaluating whether a drug which is FDA approved to treat osteoporosis may help prevent bone loss in individuals with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Respiratory Muscle Training
for Spinal Cord Injuries
Louisville, KY
18+
All Sexes
Waitlist Available
Louisville, KY
18+
All Sexes
This study is evaluating whether a breathing exercise program can improve blood pressure regulation in people with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Neuro-Spinal Scaffold
for Spinal Cord Injuries
Phoenix, AZ
Any Age
All Sexes
Waitlist Available
Phoenix, AZ
Any Age
All Sexes
This study is evaluating whether a new type of spinal cord injury treatment might be safe and effective.
Phase-Based Estimates
3
Effectiveness
3
Safety
Denosumab
for Spinal Cord Injuries (SCI)
West Orange, NJ
18+
All Sexes
Phase 4
Waitlist Available
West Orange, NJ
18+
All Sexes
Sublesional bone loss after acute spinal cord injury (SCI) is sudden, progressive, and dramatic. After depletion of bone mass and the loss of architectural integrity, it may be difficult, if even possible, to restore skeletal mass and strength. Denosumab is a relative new, highly potent anti-resorptive agent that has proven efficacy in postmenopausal osteoporosis to improve bone mass and in solid tumor patients to prevent a skeletal-related event to a greater extent than that with bisphosphonate administration. In persons with complete motor lesions, bisphosphonates have not been effective at reducing bone loss at the knee, the site of greatest relevance because of its increased risk of fracture. Anti-RANKL therapy appears to be more potent than bisphosphonates in animal models of bone loss due to immobilization, suggesting that treatment with denosumab may prove to be an efficacious therapy for persons with acute SCI to preserve bone mass and strength.
Phase-Based Estimates
2
Effectiveness
3
Safety
Maintenance Of Minimum Mean Arterial Pressure (MAP)
for Wounds
Ottawa, Canada
Any Age
All Sexes
Phase 3
Waitlist Available
Ottawa, Canada
Any Age
All Sexes
The objective of this study is to assess the efficacy of IV minocycline in improving neurological and functional outcome after acute non-penetrating traumatic spinal cord injury (SCI). The primary hypothesis is that intravenous minocycline twice daily (800 mg initial dose tapered to 400 mg by 100 mg at each dose then administered to the end of day 7) administered to subjects with acute traumatic non-penetrating cervical SCI starting within 12 hours of injury will improve motor recovery as assessed by the International Standards for Neurologic Classification of Spinal Cord Injury - ISNCSCI (a.k.a. ASIA) neurological examination measured between 3 months and 1 year post-injury, compared to placebo. The secondary hypotheses are that the above minocycline treatment will also results in improvement in ASIA sensory improvement, in ASIA grade and in functional outcome as assessed by Spinal Cord Independence Measure (SCIM) and Short Form 36 (SF-36), compared to placebo. In addition the effect of minocycline on neurological and functional outcome after SCI is expected to be more pronounced in those subjects with motor incomplete SCI compared to those with motor compete SCI. A subgroup analysis will be undertaken to examine this hypothesis.
Phase-Based Estimates
1
Effectiveness
1
Safety
Mometasone Furoate
for Spinal Cord Injuries
West Orange, NJ
18+
All Sexes
Phase 1
Waitlist Available
1 Prior Treatment
West Orange, NJ
18+
All Sexes
This study is evaluating whether a drug that may help people with asthma may also help people with cervical spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
IST-12
for Wounds
Cleveland, OH
18+
All Sexes
Waitlist Available
Cleveland, OH
18+
All Sexes
This study is evaluating whether an implanted stimulator and sensor can help people with cervical level spinal cord injury regain some function in their arms and hands.
Phase-Based Estimates
1
Effectiveness
1
Safety
Enhanced Medical Rehabilitation (EMR)
for Spinal Cord Injuries
Chicago, IL
18+
All Sexes
Waitlist Available
Chicago, IL
18+
All Sexes
To achieve higher levels of patient engagement, it is important to improve therapists' techniques for goal setting and clinician-therapist communication. Thus, the investigators have developed a manualized intervention for post-acute rehabilitation, Enhanced Medical Rehabilitation (EMR), which is an evidence-based program to increase patient engagement and achieve a greater intensity of therapy, thereby optimizing the patient's functional and psychosocial recovery. EMR is an integrated set of skills for occupational and physical therapists that transform rehabilitation through (1) a patient-directed, interactive approach; (2) increased treatment intensity; and (3) frequent feedback to patients on effort and progress. The investigators have developed training and supervision methods to enable therapists to carry out these skills with high fidelity. Due to the complexity of the inpatient spinal cord injury (SCI) rehabilitation environment, it is unknown whether the EMR program will be clinically relevant to inpatient rehabilitation settings and acceptable to SCI populations. Therefore, it is necessary to conduct a systematic adaptation approach to address all barriers, and test this adapted program to a new setting (inpatient rehabilitation) and a new population (patients with SCI), without compromising the core elements of the original EMR. Objective: The investigators propose to adopt the EMR program for use in inpatient SCI rehabilitation settings using an implementation science. The investigators propose a randomized trial of 80 patients with SCI to test the effects of EMR on improving engagement and treatment intensity, as well as functional and psychosocial outcomes over standard of care (SOC) rehabilitation. Methods: The investigators will randomize patients into EMR or SOC groups. For the EMR group, four therapists will be trained and supervised in EMR and will incorporate EMR techniques into therapy sessions. In the SOC group, four therapists will carry out therapy sessions as usual. Outcomes: With respect to EMR intervention adaptions, the investigators hypothesize that the EMR program, including a treatment manual and other materials, will be customized with input from our Spinal Cord Injury-Community Advisory Board (SCI-CAB). Patients randomized to EMR will have greater engagement and intensity and greater functional and psychosocial recovery compared to those randomized to SOC rehabilitation. Significance: Success in this research will improve therapists' skills working with patients and optimizing patient outcomes
Phase-Based Estimates
1
Effectiveness
1
Safety
Brief Prolonged Exposure Therapy
for Wounds
Dallas, TX
18+
All Sexes
Recruiting
Dallas, TX
18+
All Sexes
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an inpatient setting.
Phase-Based Estimates
1
Effectiveness
1
Safety
Combined Explosive Strength And Specific Balance Training Group
for Wounds
Montréal, Canada
18+
All Sexes
Recruiting
Montréal, Canada
18+
All Sexes
The objectives of the study are to evaluate a 4-week mixed training paradigm consisting of explosive strength training and balance perturbation training efficacy on balance control during standing and locomotion, and to understand the mechanisms of neuroplasticity that would improve sensorimotor integration at supraspinal and spinal levels.
Phase-Based Estimates
1
Effectiveness
1
Safety
Epidural Stimulation
for Spinal Cord Injuries
Los Angeles, CA
18+
All Sexes
Recruiting
Los Angeles, CA
18+
All Sexes
This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach. Participants may qualify for the study if they are male or female 18-75 years old, are at least 1 year after original injury, have injury at C2 to C7 level, and dependent on mechanical ventilation to help them breathe. Additionally, they need to be able to attend up to twice weekly testing sessions for up to 21 months.
Phase-Based Estimates
1
Effectiveness
1
Safety
Reactive Balance Training
for Spinal Cord Injuries
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a set of activities can improve balance in people with incomplete spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Epidural Stimulation + Bladder Voiding Efficiency Training
for Wounds
Louisville, KY
18+
All Sexes
Recruiting
Louisville, KY
18+
All Sexes
This study is evaluating whether epidural stimulation can improve walking and bladder function in people with spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Photovoice
for Spinal Cord Injuries
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a set of activities can improve balance and confidence in people with SCI.
Phase-Based Estimates
1
Effectiveness
1
Safety
MyoMo
for Spinal Cord Injuries (SCI)
West Orange, NJ
18+
All Sexes
Recruiting
West Orange, NJ
18+
All Sexes
This study is evaluating whether an upper extremity assistive device can improve upper extremity activities in people with incomplete spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Magnetic Resonance Imaging (MRI)
for Spinal Cord Injuries
Vancouver, Canada
18+
All Sexes
Recruiting
Vancouver, Canada
18+
All Sexes
This study is evaluating whether blood pressure and anticoagulation can improve outcomes after a spinal cord injury.
Phase-Based Estimates
1
Effectiveness
1
Safety
Percutaneous Epidural And Dorsal Root Stimulation
for Spinal Cord Injuries
Rochester, MN
18+
All Sexes
Recruiting
Rochester, MN
18+
All Sexes