Autonomic Dysfunction Clinical Trials 2023

What Are Autonomic Dysfunction Clinical trials

Autonomic Dysfunction, also called autonomic neuropathy or dysautonomia, refers to a neural condition that causes loss of function in the autonomic nervous system (ANS). The ANS is responsible for involuntary body functions such as blood pressure, digestion, temperature regulation, breathing rate, and more.

Autonomic Dysfunction develops due to damage in the ANS nerves, which consist of the sympathetic autonomic nervous system (SANS) and the parasympathetic autonomic nervous system (PANS). The exact symptoms of the condition depend on where the damage occurred in the ANS.

There are many underlying causes of autonomic dysfunction, including Riley-Day syndrome, diabetes, Parkinson's, and Lyme disease. Due to the possible causes, it is hard to treat the conditions without a proper diagnosis.

Autonomic Dysfunction clinical trials consist of patient observation to understand the condition's etiology, progression, and effects. Moreover, these trials can consist of checking the efficacy and safety of new diagnostic and treatment methods.

Why is Autonomic Dysfunction Being Studied Through Clinical Trials?

Autonomic dysfunction affects more than 70 million people globally. Moreover, the disease appears irrespective of age. While there are many precursors to the condition, there is no one cause. Autonomic dysfunction can range between mild to life-threatening and be either chronic or temporary. While the disease is not fatal, it can worsen over time.

Autonomic dysfunction causes a wide range of symptoms. If nerve damage is present in the SANS, it causes overstimulation of organs and functions. If the nerve damage is present in the PANS, it causes an under-stimulation of organs and functions, including:

• Dizziness and blurred vision.
• Excessive urination or retention, depending on whether the SANS or PANS has nerve damage.
• Erectile dysfunction and vaginal dryness.
• Diarrhea, constipation, loss of appetite, bloating, and other gastrointestinal problems.
• Excessive or decreased sweating.
• High or low blood pressure.

There is no cure for autonomic dysfunction. Due to the varying symptoms and causes, no one treatment can work for all. Currently, the available treatment methods address the symptoms rather than the cause and may have adverse effects.

Autonomic dysfunction clinical trials are conducted to study the effects of the disease and to design new treatment methods that can help treat the disease or symptoms without adverse effects.

What Are The Types of Treatment Available for Autonomic Dysfunction?

Current treatment methods are based on two approaches: addressing the underlying cause or treating the symptoms.

To manage the symptoms, patients may be prescribed different medications. For example, patients suffering from gastrointestinal problems would be prescribed Reglan (for help with bloating) or laxatives.

To treat the underlying causes, patients are prescribed medication for lifestyle changes applicable to helping them improve their health. For example, diabetes patients will receive medication to control blood sugar levels and will have to follow a diet and exercise regime.

What Are Some Recent Breakthrough Clinical Trials for Autonomic Dysfunction?

Most recent autonomic dysfunction clinical trials are centered around finding improved treatment methods for autonomic dysfunction and the underlying cause. Some of the recent breakthrough clinical trials for autonomic dysfunction include:

2021: a study (NCT04374045) by Centre Hospitalier Universitaire de Saint Etienne of the effects and possibility of autonomic dysfunction In patients infected with SARS-CoV-2, proving that SARS-CoV-2 can pass the blood-brain barrier.

2023: a phase 3 clinical trial (NCT05430217) by Valenta Phar, JSC, to study the efficacy and safety of Buspirone in patients with autonomic dysfunctions accompanied by vertigo, showing a reduction of 50% in dizziness in patients.