Autonomic Nervous System Blocker

Trimethaphan for High Blood Pressure

Phase 1
Waitlist Available
Led By Italo Biaggioni, MD
Research Sponsored by Vanderbilt University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Be younger than 18 years old
Screening 3 weeks
Treatment Varies
Follow Upafter 10 minutes of autonomic blockade
Awards & highlights
No Placebo-Only Group
All Individual Drugs Already Approved

Study Summary

This trial will study whether abdominal veins play a role in human hypertension, by testing subjects' blood pressure with and without autonomic nervous system blockade.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 10 minutes of autonomic blockade
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 10 minutes of autonomic blockade for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Splanchnic venous capacitance
Secondary outcome measures
Stroke volume
Systolic Blood Pressure

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Study day with trimethaphanExperimental Treatment1 Intervention
After baseline measurements, autonomic blockade will be induced by continuous intravenous infusion of trimethaphan starting at 0.5-1.0 mg/min and increasing by 1.0 mg/min every 2 to 6 minutes up to an infusion rate of 5 mg/min.
Group II: Radionuclide Study day with nitroglycerinExperimental Treatment1 Intervention
Sublingual nitroglycerin (0.3-0.6 mg) will be given after baseline measurements. Outcome measurements will be repeated within 10 min after the nitroglycerin has dissolved
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved
FDA approved

Find a site


Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor
695 Previous Clinical Trials
6,141,938 Total Patients Enrolled
Italo Biaggioni, MDPrincipal Investigator - Vanderbilt University
Vanderbilt University
28 Previous Clinical Trials
1,452 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can participate in this medically-supervised research project?

"This clinical trial seeks to enrol 12 individuals affected by hypertension in the age range of 18-65. Eligible applicants must be comprised of a combination of genders, races and body types. In addition, candidates for this study must have blood pressure readings greater than or equal to 140/90 mm Hg taken from two different occasions while seated as well as demonstrate their ability and willingness to provide informed consent."

Answered by AI

What other scientific experiments have been conducted with Trimethaphan as a primary focus?

"Currently, seven clinical trials are being conducted with Trimethaphan. None of them have entered their final phase yet. Most tests for this treatment take place in New York City, but other US cities such as Miami and San Francisco also offer it."

Answered by AI

Is enrollment still underway for this investigation?

"According to, the recruitment process for this medical trial is ongoing. The study was initially uploaded on April 1st 2015 and recently updated August 21st 2022."

Answered by AI

Does this research embrace seniors as participants?

"This trial is open to anyone aged 18-65, with 55 clinical trials designated for those younger than the age of consent and an additional 666 studies available for participants over 65 years old."

Answered by AI

What maladies have been known to respond best to Trimethaphan?

"Trimethaphan is commonly used to manage myocardial infarction but can be employed for various other purposes such as treating anal fissure, angina attacks, and pain."

Answered by AI

How many individuals can participate in this experiment?

"Affirmative. Per the information published on, this medical trial is still recruiting participants and began doing so since April 1st 2015. The latest update was posted on August 21st 2022 and 12 patients are needed from one site only."

Answered by AI

Has Trimethaphan been recognized by the FDA as a viable form of treatment?

"Our team at Power assigned Trimethaphan a safety score of 1, as this is an early Phase 1 trial with limited evidence for both efficacy and security."

Answered by AI
~1 spots leftby Jul 2024