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Electrical Stimulation for Spinal Cord Injury

N/A
Recruiting
Led By Monica Perez, PT PhD
Research Sponsored by Shirley Ryan AbilityLab
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Inclusion criteria for individuals with SCI: Male and females between 18-85 years, Chronic SCI (≥ 6 months post injury), Cervical injury at C8 or above, Intact or impaired but not absent innervations in dermatomes C6, C7, and C8 using the American Spinal Injury Association sensory scores, Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
Inclusion criteria for healthy controls: Male and females between 18-85 years, Right handed, Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 months
Awards & highlights

Study Summary

This trial is investigating new ways to improve motor function in people with spinal cord injuries by using electrical stimulation.

Who is the study for?
This trial is for adults aged 18-85 with chronic spinal cord injury (SCI) at C8 or above, who can still perform certain reach and grasp movements. It's also open to right-handed healthy controls without SCI but with similar abilities. Pregnant women, individuals with metal in the skull, seizure history, severe medical issues, depression/psychosis, head injury/stroke history, pacemakers or those on specific CNS drugs are excluded.Check my eligibility
What is being tested?
The study aims to improve motor function in people with SCI using advanced electrophysiological methods to test corticospinal connections. Participants will undergo assessments of muscle response timing and location plus training that includes some form of stimulation focused on enhancing reach and grasp movements.See study design
What are the potential side effects?
While not explicitly listed in the provided information, potential side effects may include discomfort from electrical stimulation during electrophysiology assessments and training sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18-85 years old with a spinal cord injury at C8 or above, and can still move my hands.
Select...
I am between 18-85 years old, right-handed, and can reach and grasp objects without leaning forward.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Upper-limb motor function
Secondary outcome measures
Change in Sensorimotor Function
Cortical Neurophysiological Outcome

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Electrophysiology Assessment of Time DomainExperimental Treatment2 Interventions
Assessment of electrophysiology in the time domain to examin temporal organization of corticospinal function
Group II: Electrophysiology Assessment of LocationExperimental Treatment2 Interventions
Assessment of electrophysiology to examine spatial organization of corticospinal function
Group III: Training with some stimulationActive Control1 Intervention
Training with non-invasive stimulation and training with sham stimulation

Find a Location

Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
192 Previous Clinical Trials
14,585 Total Patients Enrolled
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,337 Previous Clinical Trials
648,544 Total Patients Enrolled
Monica Perez, PT PhD5.01 ReviewsPrincipal Investigator - Shirley Ryan AbilityLab
Shirley Ryan AbilityLab

Media Library

Electrophysiology Assessment of Location Clinical Trial Eligibility Overview. Trial Name: NCT02451683 — N/A
Spinal Cord Injury Research Study Groups: Electrophysiology Assessment of Time Domain, Electrophysiology Assessment of Location, Training with some stimulation
Spinal Cord Injury Clinical Trial 2023: Electrophysiology Assessment of Location Highlights & Side Effects. Trial Name: NCT02451683 — N/A
Electrophysiology Assessment of Location 2023 Treatment Timeline for Medical Study. Trial Name: NCT02451683 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are permitted to join this experiment?

"Affirmative. The details on clinicaltrials.gov reveal that this medical research is actively enrolling participants, commencing from October 12th 2020 and most recently updated on May 21st 2021. 300 patients are sought for the study at a single site of enrolment."

Answered by AI

What are the eligibility requirements to participate in this research?

"The specified medical trial seeks 300 male and female participants between 18 to 85 years with spinal cord injuries that meet the following requirements: American Spinal Injury Association sensory scores must demonstrate intact or impaired but not absent innervations in dermatomes C6, C7, and C8. Additionally they need to be able to grasp a small object 8 cm away without leaning forward with their trunk while being right handed."

Answered by AI

Does this clinical exploration accept volunteers over the age of 55?

"This trial is open to patients aged between 18 and 85 years old. Those younger than 18 are eligible for 138 other studies, while 735 trials accept participants over 65."

Answered by AI

Is this clinical investigation currently accepting participants?

"Indeed, the trial is still open to applicants. It was initially advertised on October 12th 2020 and most recently revised on May 21st 2021 according to clinicaltrials.gov's listing."

Answered by AI

Who else is applying?

How old are they?
18 - 65
What site did they apply to?
Shirley Ryan AbilityLab
What portion of applicants met pre-screening criteria?
Met criteria
~102 spots leftby Dec 2025