SBRT vs IMRT for Prostate Cancer
Trial Summary
Will I have to stop taking my current medications?
If you are taking a 5-alpha reductase inhibitor, you will need to stop it before starting the trial, but no specific time without the medication is required. Other medications are not mentioned, so the protocol does not specify if you need to stop them.
What data supports the effectiveness of the treatment SBRT vs IMRT for Prostate Cancer?
Is SBRT or IMRT safe for treating prostate cancer?
Research shows that both SBRT and IMRT are generally safe for treating prostate cancer, with low rates of severe side effects. Patients report maintaining a good quality of life, and studies indicate low levels of gastrointestinal (stomach and intestines) and genitourinary (urinary and reproductive organs) side effects.12346
How does the treatment SBRT differ from IMRT for prostate cancer?
SBRT (Stereotactic Body Radiation Therapy) is unique because it offers a shorter treatment duration and potentially lower cost compared to IMRT (Intensity-Modulated Radiation Therapy). SBRT can deliver a higher dose of radiation in fewer sessions, which may lead to different toxicity profiles and patient experiences.12357
What is the purpose of this trial?
This randomized phase III trial studies how well stereotactic body radiation therapy works compared to intensity-modulated radiation therapy in treating patients with stage IIA-B prostate cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the tumor using smaller doses over several days and may cause less damage to normal tissue. Stereotactic body radiation therapy may work better in treating patients with prostate cancer.
Research Team
Rodney Ellis
Principal Investigator
NRG Oncology
Eligibility Criteria
Men with early-stage prostate cancer (stage IIA-B) who haven't had previous treatments are eligible. They must have a prostate size less than 70 cc, specific PSA levels depending on their Gleason score, and be in good physical condition. Men over 60 can have slightly more health issues. Only English, Spanish, and French speakers who agree to fill out questionnaires can join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo either IMRT or SBRT radiation therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Intensity-Modulated Radiation Therapy (IMRT)
- Stereotactic Body Radiation Therapy (SBRT)
Find a Clinic Near You
Who Is Running the Clinical Trial?
NRG Oncology
Lead Sponsor
National Cancer Institute (NCI)
Collaborator