Study Summary
This trial is testing a new combination of drugs for people with advanced esophageal and gastric cancer. Thenew combination is hoped to be better tolerated than current first-line chemotherapy combinations.
- Stomach Cancer
- Esophageal Cancer
Treatment Effectiveness
Effectiveness Progress
Study Objectives
4 Primary · 8 Secondary · Reporting Duration: up to 2 years
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
Cohort 2: HER2 Positive
1 of 4
Cohort 4: HER2 Positive
1 of 4
Cohort 3: HER2 Negative
1 of 4
Cohort 1: HER2 Negative
1 of 4
Experimental Treatment
52 Total Participants · 4 Treatment Groups
Primary Treatment: 5-FU · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 7 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Has the FDA evaluated 5-FU for safety and efficacy?
"5-FU has not been proven effective yet, but there is some evidence that it is safe. Therefore, it received a score of 2." - Anonymous Online Contributor
Are there any open vacancies for participants in this experiment?
"This trial, which was first posted on July 13th 2020 and updated November 14th 2020 is still recruiting patients according to the latest information from clinicaltrials.gov" - Anonymous Online Contributor
What benefit has 5-FU been shown to have for patients?
"5-FU, which is most often used to treat small cell lung cancer (sclc), can also be effective at managing rectal carcinoma, colorectal carcinoma, and ovarian cancer." - Anonymous Online Contributor
What are the primary goals of this research?
"This clinical trial's primary goal is to evaluate Objective Response Rate (ORR) in Cohort 1 over the course of up to one year. Additionally, this study will also collect data on Secondary outcomes including Incidence of Adverse Events, Progression Free Survival (PFS), and Overall Response Rate in Cohorts 2 and 4." - Anonymous Online Contributor
What do we know about 5-FU from previous research?
"At present, there are 820 ongoing clinical trials studying 5-FU. Of these, 237 are in Phase 3. Most of the 5-FU clinical trials are based in Seattle, Washington; however, there are 37990 locations around the world where such trials are taking place." - Anonymous Online Contributor
How many people total are participating in this trial?
"That is accurate. If you refer to the information on clinicaltrials.gov, you will see that this trial has an open recruitment and was first posted on 7/13/2020. The study is looking for 52 patients at 1 sites." - Anonymous Online Contributor