Indoor Air Quality Monitor for Smoking Cessation

Recruiting at 7 trial locations

Overseen By Gleneara Bates-Pappas, PhD, LMSW

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Memorial Sloan Kettering Cancer Center

Disqualifiers: Smoke-free home

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 2 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 14

Duration: 8 weeks

10 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether an indoor air quality monitor (AirGradient ONE) can help cancer patients quit smoking by maintaining smoke-free homes. The focus is on patients who currently smoke and participate in a tobacco treatment program. Eligible participants must be cancer patients who smoke, have completed an initial counseling session in the program, and have Wi-Fi at home. The trial aims to determine if tracking indoor air quality can support smoking cessation efforts. As an unphased trial, this study provides a unique opportunity for patients to contribute to innovative research that may enhance their journey to quit smoking.

Do I need to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on using an air quality monitor to help quit smoking, so it's best to ask the trial coordinators for more details.

What prior data suggests that this indoor air quality monitor is safe for use in smoking cessation?

Research has shown that the AirGradient ONE indoor air quality monitor is highly accurate, particularly in detecting harmful particles like PM2.5 and other air pollutants. Safety standards such as CE and FCC have tested and approved the device, confirming it meets strict safety and quality guidelines.

As a monitor rather than a medication, the device poses no direct health risks to users. Its purpose is to track indoor air quality, serving as a safe tool for promoting a smoke-free home. No reports of negative effects from its use have been documented. ^{1 2 3 4 5}

Why are researchers excited about this trial?

The Indoor Air Quality Monitor AirGradient ONE is unique because it offers a tech-driven approach to smoking cessation by directly monitoring and improving indoor air quality. Unlike traditional methods like nicotine replacement therapies or medications that target cravings, this device provides real-time data on air pollutants, potentially motivating smokers to reduce their smoking habits by making them more aware of the impact on their environment. Researchers are excited about this trial because it explores a novel, non-invasive way to encourage smoking cessation by leveraging environmental feedback rather than chemical interventions.

What evidence suggests that using an indoor air quality monitor is effective for promoting a smoke-free home?

Research has shown that using an indoor air quality monitor can encourage people to smoke less indoors. Although these monitors did not significantly increase the number of people who quit smoking altogether, they did help some change their smoking habits. In this trial, participants will use the AirGradient ONE monitor, which provides real-time updates on air quality. This allows users to see how smoke affects their surroundings, and this visual feedback can strongly motivate smokers to reduce or stop smoking indoors. Early findings suggest this method could help promote smoke-free homes, especially for those receiving assistance to quit smoking. ^{1 2 3 6 7}

Who Is on the Research Team?

Gleneara Bates-Pappas, PhD, LMSW

Principal Investigator

Memorial Sloan Kettering Cancer Center

Are You a Good Fit for This Trial?

This trial is for cancer patients trying to quit smoking and are enrolled in MSK's Tobacco Treatment Program. It aims to see if using an air quality monitor helps them keep their homes smoke-free.

Inclusion Criteria

Has been referred and enrolled in the MSK TTP and completed the initial counseling session as per the TTP clinical database

Reports current (within the past 30 days) tobacco use (i.e., cigarettes and/or any other tobacco products) as per the TTP Intake form

I can be contacted by phone.

Exclusion Criteria

N/A

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use an indoor air quality monitor and attend smoke-free workshop sessions

8 weeks

Participants use the device for 14 consecutive days and attend workshops

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Indoor Air Quality Monitor AirGradient ONE

Trial Overview The study is testing the effectiveness of the AirGradient ONE indoor air quality monitor in encouraging a smoke-free environment at home among participants.

How Is the Trial Designed?

Group I: MSK Participants who are current smokers Experimental Treatment 1 Intervention

10 MSK participants who are current smokers and receiving tobacco treatment will be enrolled.

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials

1,998

Recruited

602,000+

Published Research Related to This Trial

The Personal Automatic Cigarette Tracker (PACT) is a new wearable sensor system that accurately monitors smoking behavior without requiring conscious effort from the user, tested on 20 individuals performing various activities.

The system detects unique breathing patterns associated with smoking, which can help identify individual smoke inhalations and potentially improve the assessment of smoking interventions in real-world settings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A wearable sensor system for monitoring cigarette smoking. Sazonov, E., Lopez-Meyer, P., Tiffany, S.[2021]

The smartphone-enabled iCO monitor consistently provided higher carbon monoxide (CO) readings compared to the Micro+ pro and Micro+ basic monitors, indicating that different devices yield different results.

To accurately determine smoking abstinence, specific CO cutoff values are necessary: <3 ppm for the Micro+ monitors and <6 ppm for the iCO monitor, highlighting the importance of using the correct device-specific thresholds for bioverification.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Mobile, Remote, and Individual Focused: Comparing Breath Carbon Monoxide Readings and Abstinence Between Smartphone-Enabled and Stand-Alone Monitors. Tuck, BM., Karelitz, JL., Tomko, RL., et al.[2021]

The study involved 39 pregnant women who smoke, and qualitative interviews revealed that while many wanted to change their smoking behaviors, external factors like living with other smokers often hindered their commitment to quitting.

Although indoor air quality (IAQ) measurements did not significantly improve overall quit rates, they did help some women modify their smoking behaviors, suggesting that this approach could be beneficial in supporting smoking cessation efforts during pregnancy.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

An interview study of pregnant women who were provided with indoor air quality measurements of second hand smoke to help them quit smoking. Morgan, H., Treasure, E., Tabib, M., et al.[2021]

In a pilot study with 29 smoking families, real-time feedback from air quality monitors (like the Dylos) was effective in providing clear information about tobacco smoke air pollution (TSAP) levels, which could encourage parents to create smoke-free homes.

Continuous monitoring of PM(2.5) levels was less effective due to noise and misleading peaks from non-smoking sources, highlighting the need for improved measurement techniques and real-time feedback systems to better protect children from tobacco smoke exposure.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Feasibility of Measuring Tobacco Smoke Air Pollution in Homes: Report from a Pilot Study. Rosen, L., Zucker, D., Hovell, M., et al.[2018]

The use of active portable high-efficiency particulate air cleaners showed a significant reduction in respiratory symptoms and moderate exacerbations in former smokers with COPD over a 6-month period, indicating potential health benefits from reducing indoor particulate matter.

Participants who adhered to using the air cleaners and spent more time indoors experienced greater improvements in their respiratory health, suggesting that these devices could be particularly effective for individuals with COPD in indoor environments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study. Hansel, NN., Putcha, N., Woo, H., et al.[2023]

The mobile-phone-based Breath CO meter prototype demonstrated a strong correlation with a commercial Breath CO meter (r = .96), indicating its reliability and validity for measuring carbon monoxide levels in breath.

Participants found the mobile meter acceptable and expressed interest in using it for smoking cessation, suggesting it could be a valuable tool for supporting quit attempts.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A mobile-phone-based breath carbon monoxide meter to detect cigarette smoking. Meredith, SE., Robinson, A., Erb, P., et al.[2023]

The study found that the Bedfont piCO+ Smokerlyzer consistently reported higher expired-air carbon monoxide (CO) levels than the Vitalograph BreathCO, with an average difference of 3.83 ppm, indicating a lack of agreement between the two monitors.

This discrepancy in CO measurements suggests that the choice of monitor can significantly affect the classification of smoking abstinence, which is crucial for smoking research and treatment outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

ANALYSIS OF AGREEMENT BETWEEN EXPIRED-AIR CARBON MONOXIDE MONITORS. Karelitz, JL., Michael, VC., Perkins, KA.[2022]

The Bedfont EC50 is a new, portable, and inexpensive analyzer for measuring expired-air carbon monoxide, which has shown good correlation with standard measurement methods in a study of 138 normal subjects.

This new analyzer is more effective at accurately identifying smoking status compared to traditional methods, making it a valuable tool for both field and clinical settings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Evaluation of a portable measure of expired-air carbon monoxide. Irving, JM., Clark, EC., Crombie, IK., et al.[2019]

In a 6-month study involving 116 former smokers with COPD, 76.1% of participants adhered to using portable air cleaners at least 80% of the time, which could potentially improve their respiratory health by reducing indoor pollutants.

Factors such as higher household income and using electric heating were linked to better adherence, while lower quality of life and recent exacerbations were associated with lower adherence, indicating that socioeconomic and health status play crucial roles in the effectiveness of air cleaner interventions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Patterns and Predictors of Air Cleaner Adherence Among Adults with COPD. Lorizio, W., Woo, H., McCormack, MC., et al.[2022]

The Beijing Indoor Air Purifier Study (BIAPSY) demonstrated that active air filtration significantly reduced indoor air pollutants, including PM2.5 and black carbon, improving air quality in homes over a two-week period.

Despite the improvements in air quality, the study found no significant changes in lung function, blood pressure, or heart rate variability among participants, indicating that while air filtration is effective for reducing pollutants, it may not lead to immediate cardio-respiratory health benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier StudY, BIAPSY. Shao, D., Du, Y., Liu, S., et al.[2019]

The Novel Tobacco Vapor (NTV) product was found to produce emissions that are chemically simpler than traditional cigarette smoke, indicating a potentially less harmful alternative.

In controlled simulations of both non-smoking and smoking environments, the use of the NTV product did not significantly affect indoor air quality, with no measurable increases in harmful substances like formaldehyde or ammonia.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Indoor air quality (IAQ) evaluation of a Novel Tobacco Vapor (NTV) product. Ichitsubo, H., Kotaki, M.[2023]

A new portable internet-connected air quality monitor was developed and tested in eight homes in Israel, showing less than 1% data loss and reliable real-time monitoring of secondhand smoke exposure.

The remote monitoring system provided data comparable to traditional methods, indicating it could effectively support interventions aimed at reducing secondhand smoke in homes, particularly benefiting children's health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Monitoring secondhand tobacco smoke remotely in real-time: A simple low-cost approach. Dobson, R., Rosen, LJ., Semple, S.[2023]

In a randomized controlled trial involving 126 children with asthma living with smokers, the use of air cleaners significantly reduced indoor particulate matter (PM) concentrations and increased symptom-free days compared to a control group without air cleaners.

However, the intervention did not significantly lower air nicotine or urine cotinine levels, indicating that while air cleaners help improve air quality, they are not sufficient to completely eliminate secondhand smoke exposure.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Butz, AM., Matsui, EC., Breysse, P., et al.[2021]

Heat-not-burn (HnB) products emit lower levels of nicotine (0.8-1.2 mg per cigarette) compared to conventional cigarettes (2.4-3.6 mg per cigarette), suggesting a potential reduction in nicotine exposure for users.

However, HnB products release higher levels of vegetable glycerin (3.1-5.9 mg per cigarette) than conventional cigarettes, and they still produce various volatile organic compounds (VOCs), aldehydes, nanoparticles, and particulate matter, which negatively impact indoor air quality.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Preliminary study on the effect of using heat-not-burn tobacco products on indoor air quality. Yu, SJ., Kwon, MK., Choi, W., et al.[2022]

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT06693700?term=Freedom%20to%20Breathe:%20Pilot%20Study%20Towards%20Achieving%20Environmental%20Justice%20for%20Cancer%20Patients%20and%20Their%20Families&rank=1

A Study Evaluating the Use of an Indoor Air Quality Monitor ... The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's ...

2. centerwatch.com centerwatch.com/clinical-trials/listings/NCT06693700/a-study-evaluating-the-use-of-an-indoor-air-quality-monitor-to-promote-a-smoke-free-home

A Study Evaluating the Use of an Indoor Air Quality Monitor ... The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are ...

3. withpower.com withpower.com/trial/indoor-air-quality-monitor-for-smoking-cessation-6f0e5

Indoor Air Quality Monitor for Smoking Cessation Although indoor air quality (IAQ) measurements did not significantly improve overall quit rates, they did help some women modify their smoking behaviors, ...

4. airgradient.com airgradient.com/indoor/

Indoor Air Quality Monitor The AirGradient ONE (Model I-9PSL) is an indoor air quality monitor enabling you to know if the air quality is healthy or not.

5. airgradient.com airgradient.com/shop/#!/AirGradient-ONE-Indoor-Monitor-Fully-Assembled-and-Tested-Version-9/p/594725504/category=155176011

AirGradient ONE Indoor Monitor I-9PSL (Fully Assembled & ... Fully open-source code so you can easily make adjustments. Tested in our test chamber with test report. Certified: CE, FCC, RoHS, REACH, RESET Air.

6. airgradient.com airgradient.com/documents/spec-sheets/Spec_Sheet_AirGradient_ONE_I-9PSL.pdf

Spec Sheet Model I-9PSL Indoor Monitor AG One AirGradient ONE is an indoor air quality monitor that lets you know if the air you're breathing is healthy. It measures CO2,. PM2.5, TVOCs, NOx, Temperature ...

7. youtube.com youtube.com/watch?v=ZfoC20tJOn8

AirGradient ONE Indoor Air Quality Monitor REVIEW! // BEST ... This unit in particular is the AirGradient I-9PSL-DE and we found the accuracy of this unit to be exceptional, except for the CO2 readings ...