22 Participants Needed

Opioid Tapering for Chronic Pain

Recruiting at 1 trial location
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to find out if patients who have been taking a stable dose of opioids for chronic pain would experience any worsening pain, quality of life and functioning, as well as symptoms of depression and anxiety if their opioid medications are gradually and very slowly reduced.

Who Is on the Research Team?

TW

Terrence Witt, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for patients under chronic opioid therapy for pain, prescribed by MCHS NW WI, with a daily dose ≤90 MME using specific opioids in tablet/capsule form. Participants must be able to consent and commit to the study's requirements. Exclusions include active/planned pregnancy, cancer treatment (except certain skin cancers), non-chronic pain opioid use, hospice care, recent suicidal intent or misuse of controlled medications.

Inclusion Criteria

I take 90mg or less of pain medication daily.
My doctor agrees with me joining the trial and prescribes opioids for chronic pain.
Ability to provide consent
See 2 more

Exclusion Criteria

I am currently using methadone or buprenorphine.
I am currently undergoing or planning to start cancer treatment, excluding hormonal therapy and treatments for non-melanoma skin cancers.
Known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder adherence
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either continued opioid therapy or undergo slow tapering of opioid doses

12 months
Visits at baseline, 3 months, 6 months, 9 months, and 12 months

Follow-up

Participants are monitored for changes in pain, quality of life, depression, and anxiety

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Slow Tapering of Chronic Opioid Therapy
Trial Overview The study tests if very slow tapering of opioids worsens pain, quality of life, depression or anxiety in patients on stable long-term doses for chronic pain. It aims to understand the effects of reducing opioid medication gradually over time.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Slow Tapering of Chronic Opioid TherapyExperimental Treatment1 Intervention
Group II: Continued Opioid TherapyActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security