Cannabidiol for Pain
(CAM-POT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how Cannabidiol (CBD) might manage pain and improve quality of life after a bone fracture. It compares two different doses of CBD and a placebo (a pill with no active ingredient) to determine which is most effective for pain relief, sleep, mood, and more. Individuals with a lower or upper limb fracture treated at Sacre-Coeur Hospital in Montreal within a week of injury may be eligible to participate. As a Phase 2 trial, the research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it excludes patients who are taking warfarin, sildenafil, valproate, or opioids before their injury. It's best to discuss your specific medications with the trial team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that cannabidiol (CBD) is generally safe for people. Most studies have found it to be well-tolerated, though some side effects can occur. Common side effects include dry mouth, diarrhea, reduced appetite, and drowsiness, which are usually mild.
When considering joining a trial, it's important to know that CBD has undergone safety studies. Although some research suggests it might not alleviate chronic pain, safety data indicates it is unlikely to cause serious harm. This trial tests different doses, so participants should monitor how they feel throughout the study.12345Why do researchers think this study treatment might be promising for pain?
Researchers are excited about cannabidiol (CBD) for pain management because it offers a fresh approach compared to traditional painkillers like opioids and nonsteroidal anti-inflammatory drugs (NSAIDs). Unlike these standard treatments, which often come with significant side effects and risk of addiction, CBD is derived from cannabis and may provide pain relief without these issues. Additionally, CBD works by interacting with the body's endocannabinoid system, which is different from how most current pain medications operate. This unique mechanism of action could potentially offer effective pain relief for those who don't respond well to existing options.
What evidence suggests that Cannabidiol might be an effective treatment for pain?
Research has shown mixed results for cannabidiol (CBD) in managing pain. Some studies found that CBD reduced pain by 42% to 66%. However, other research suggested that CBD might not be much better than a placebo, which contains no active ingredient. Overall, while some people report feeling better using CBD, its effectiveness for pain relief remains debated. This study aims to clarify how well CBD works for managing pain. Participants in this trial will receive either a low or moderate dose of CBD, or a placebo, to evaluate its effectiveness.678910
Are You a Good Fit for This Trial?
This trial is for patients at Hopital du Sacre-Coeur de Montreal who have had a long bone fracture within the past 72 hours, with or without mild traumatic brain injury. Participants must give informed consent to join.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a low or moderate dose of CBD or placebo orally twice daily for one month
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of pain, inflammation, and various psychological and functional outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Cannabidiol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Lead Sponsor