Hormone Therapy
Angiotensin-(1-7) for Cardiovascular Health in Aging
This trial will test whether angiotensin-(1-7), a hormone that protects against the renin-angiotensin system, can reduce the risk of cardiovascular disease in older adults by reducing sympathetic outflow and blood pressure and improving endothelial function.
Neuromodulation
Brain Stimulation for Stress
This trial is testing whether using a non-invasive brain stimulation technique will change how people respond to stress. Healthy participants will do tasks in an MRI machine, then receive brain stimulation in two sessions - one
Generic Cardiovascular Medications
Free Generic Samples for High Cholesterol
In this randomized controlled trial, we will provide primary care physicians with free samples of highly effective generic cardiovascular medications. We will test whether this intervention will stimulate cost-effective prescribing, reducing drug costs and improving adherence to essential cardiovascular medications.
Behavioural Intervention
Participant Referral to Primary Care Network Physician for Cardiovascular Disease
High blood pressure, elevated blood glucose and high cholesterol are related to the increased risk of stroke and heart disease. Many studies have shown that this risk can be significantly reduced by lowering blood pressure, blood glucose and cholesterol levels. Through a collaborative effort between Calgary Safeway pharmacists and Calgary Health Region family physician PCN's, U-CHAMP will deliver a program to assist in the identification and management of people with elevated blood pressure, blood glucose and cholesterol and through this effort, reduce the risk of heart disease and stroke in the urban Calgary population aged 18-85 years.
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Trials for Cardiovascular Disease Patients
ASD Occluder
reSept ASD Occluder for Atrial Septal Defect
This trial is testing the safety and effectiveness of the reSept ASD Occluder, a device that closes a specific type of heart hole. It targets patients with secundum atrial septal defect and works by sealing the hole like a patch.
Tissue Engineering
Tissue Engineered Vascular Grafts for Heart Disease
This trial is testing a new type of surgery for people with heart problems. The new surgery is called "extracardiac total cavopulmonary connection." This trial is testing to see if the new surgery is safe and if it works well.
Behavioral Intervention
Early Mobilization for Cardiovascular Disease
This trial aims to introduce and implement a program that helps cardiac patients move more in the hospital, which has been shown to improve their health and increase the chance of going home sooner. The study will focus
Behavioral Intervention
Web-based Heart Healthy Program for Cardiovascular Disease
Heart disease is the leading cause of death in the United States, accounting for approximately 700,000 deaths a year. Heart disease can take many forms, including heart attacks, coronary artery disease, aneurysms, high blood pressure, and strokes. However, people can change things in their life to reduce the risk of getting heart disease. This study will first create an Internet-based program to help teach people about reducing heart disease risk and will then test the program in a workplace setting.
Behavioural Intervention
High risk assessment +1 More for Cardiovascular Disease
Research has shown that the presence of heart disease and stroke is higher in the Indo-Asian population compared to other ethno-cultural groups. This may be due to multiple reasons such as a higher presence of diabetes, high blood pressure, high cholesterol, obesity, and lower levels of physical activity. This program will bring together the Calgary Indo-Central-Asian communities and the Calgary Healthcare community to help reduce the rate of heart disease and stroke through a supportive, culturally-sensitive program that is community-based through the following steps: 1. Increase awareness of heart disease and stroke through education among the Calgary Indo-Central-Asian population. 2. Identify early, the risk factors related to heart disease and stroke through screening programs. 3. Provide appropriate follow-up care to the population at risk for heart disease and stroke.
Trials for CVD Patients
ASD Occluder
reSept ASD Occluder for Atrial Septal Defect
This trial is testing the safety and effectiveness of the reSept ASD Occluder, a device that closes a specific type of heart hole. It targets patients with secundum atrial septal defect and works by sealing the hole like a patch.
Tissue Engineering
Tissue Engineered Vascular Grafts for Heart Disease
This trial is testing a new type of surgery for people with heart problems. The new surgery is called "extracardiac total cavopulmonary connection." This trial is testing to see if the new surgery is safe and if it works well.
Behavioral Intervention
Early Mobilization for Cardiovascular Disease
This trial aims to introduce and implement a program that helps cardiac patients move more in the hospital, which has been shown to improve their health and increase the chance of going home sooner. The study will focus
Behavioral Intervention
Web-based Heart Healthy Program for Cardiovascular Disease
Heart disease is the leading cause of death in the United States, accounting for approximately 700,000 deaths a year. Heart disease can take many forms, including heart attacks, coronary artery disease, aneurysms, high blood pressure, and strokes. However, people can change things in their life to reduce the risk of getting heart disease. This study will first create an Internet-based program to help teach people about reducing heart disease risk and will then test the program in a workplace setting.
Behavioural Intervention
High risk assessment +1 More for Cardiovascular Disease
Research has shown that the presence of heart disease and stroke is higher in the Indo-Asian population compared to other ethno-cultural groups. This may be due to multiple reasons such as a higher presence of diabetes, high blood pressure, high cholesterol, obesity, and lower levels of physical activity. This program will bring together the Calgary Indo-Central-Asian communities and the Calgary Healthcare community to help reduce the rate of heart disease and stroke through a supportive, culturally-sensitive program that is community-based through the following steps: 1. Increase awareness of heart disease and stroke through education among the Calgary Indo-Central-Asian population. 2. Identify early, the risk factors related to heart disease and stroke through screening programs. 3. Provide appropriate follow-up care to the population at risk for heart disease and stroke.
Phase 3 Trials
cell therapy for Cardiovascular Disease
This is the clinical registry of cell based therapies that is available to researchers around the world. The registry is web based. All researches must provide IRB approval to the coordinating site- University of Utah in order to obtain access to the registry. The are predetermined case report forms for cardiovascular diseases that are currently in clinical trials- including demographics, safety, and possible efficacy end-points. All investigators have access to their own data. The servers are U.S. HIPPA compliant and protected with secure back-up.
Physician Payment Models for Heart Conditions
This trial will compare two models for physician payment, one in which physicians are paid a fee for each service provided (fee-for-service), and one in which physicians are given a bonus for meeting quality standards (pay-for-performance). The goal is to see if the pay-for-performance model results in better care for patients with heart conditions.
RNA-based Therapeutic
Inclisiran for Cardiovascular Disease
This trial tests inclisiran, a new injection to lower cholesterol, in people who have had heart attacks, strokes, or surgeries for blocked arteries. It works by blocking a protein that produces bad cholesterol.
Trials With No Placebo
Behavioral Intervention
Telenutrition for Obesity in Spinal Cord Injury
This trial will provide nutrition counseling to obese people with spinal cord injuries via FaceTime, in order to improve their eating habits and heart health. There will be 3 in-person visits required, spaced 3 months apart, for a total trial length of 6 months.
ASD Occluder
reSept ASD Occluder for Atrial Septal Defect
This trial is testing the safety and effectiveness of the reSept ASD Occluder, a device that closes a specific type of heart hole. It targets patients with secundum atrial septal defect and works by sealing the hole like a patch.
Tissue Engineering
Tissue Engineered Vascular Grafts for Heart Disease
This trial is testing a new type of surgery for people with heart problems. The new surgery is called "extracardiac total cavopulmonary connection." This trial is testing to see if the new surgery is safe and if it works well.
View More Related Trials
Frequently Asked Questions
Introduction to cardiovascular
What are the top hospitals conducting cardiovascular research?
Cutting-edge cardiovascular research is taking place at top hospitals across the United States, paving the way for improved treatments and outcomes for patients with heart conditions. One notable institution leading the charge is the National Institutes of Health Clinical Center in Bethesda. While they currently have four active cardiovascular trials underway, their commitment to advancing cardiac medicine extends beyond specific numbers; it lies in their esteemed reputation as a premier research facility. Similarly, the University of Kansas Medical Center in Kansas City has three ongoing cardiovascular trials that demonstrate their dedication to exploring innovative approaches to heart health.
In Charlottesville, Virginia, the University of Virginia focuses its efforts on cardiovascular research with three active trials and an impressive history of one previously conducted trial dating back to 2021. This young but promising track record demonstrates their commitment to advancing knowledge and treatment options for individuals affected by heart disease.
Meanwhile, Vanderbilt University in Nashville has also emerged as a leader in cardiovascular clinical trials with three ongoing studies aimed at addressing various aspects of cardiac health. Rounding out this list is Excel Medical Clinical Trials located in Boca Raton—a dynamic center contributing significantly through its involvement in three current cardiovascular trials.
These hospitals represent a collective force that strives towards enhancing our understanding of cardiovascular diseases while continually pushing boundaries within medical science and patient care. Their relentless pursuit not only promises new therapeutic breakthroughs but also brings hope to millions around the country living with or impacted by heart-related conditions. Together, these institutions exemplify how collaboration between dedicated researchers and cutting-edge facilities can shape a healthier future for all individuals battling against cardiac ailments
Which are the best cities for cardiovascular clinical trials?
When it comes to cardiovascular clinical trials, several cities emerge as leading hubs for research and development. Boston, Massachusetts is at the forefront with 11 active trials investigating treatments like Olpasiran, reSept ASD Occluder, and Inclisiran. New york, New York follows closely behind with 9 ongoing studies exploring interventions such as Red Blood Cell therapy and BLB Intervention alongside other potential breakthroughs. Las Vegas, Nevada also shows promise with 9 active trials focused on investigational drugs like Orforglipron and Olezarsen. Lastly, Aurora, Colorado and Jacksonville, Florida both exhibit strong involvement in cardiovascular clinical trials with 8 active studies each targeting various treatments for conditions including ASCVD. These cities offer individuals seeking innovative approaches to cardiovascular care access to cutting-edge clinical research that paves the way for advancements in treatment options and potentially improved outcomes.
Which are the top treatments for cardiovascular being explored in clinical trials?
Clinical trials exploring potential treatments for cardiovascular conditions are currently centered around one promising approach: one bout of moderate-intensity sub-maximal aerobic exercise. This innovative method is being tested in a single active trial, which marks the only cardiovascular trial thus far. Its initial listing in 2022 indicates its recent emergence as a frontrunner among researchers seeking novel ways to address cardiovascular health concerns. As scientists delve further into this avenue of exploration, they hope to uncover new insights and possibilities for patients worldwide.
What are the most recent clinical trials for cardiovascular?
Recent clinical trials in the field of cardiovascular research have uncovered promising developments. One notable study focuses on moderate intensity, continuous training (MICT) as a potential intervention for patients with cardiovascular conditions. Another trial examines the efficacy of Orforglipron in treating these ailments, while a separate investigation explores the use of melatonin for cardiovascular health. Additionally, researchers are studying Olpasiran and LY3473329 Dose 1 to assess their impact on people suffering from cardiovascular issues. These innovative trials shed light on potential breakthroughs that could lead to improved treatments and outcomes for individuals with cardiovascular conditions.
What cardiovascular clinical trials were recently completed?
Several significant cardiovascular clinical trials have recently concluded, bringing us closer to advancements in the field of cardiac health. One such trial was completed by Johns Hopkins University in November 2021, exploring a new therapy's effectiveness in reducing heart failure risks. In September 2021, the National Heart, Lung, and Blood Institute wrapped up their trial investigating a novel medication for treating high blood pressure. Additionally, Emory University successfully concluded a trial in January 2021 that examined the impact of lifestyle interventions on preventing heart disease. These groundbreaking studies contribute invaluable insights into cardiovascular care and pave the way for improved treatments and prevention strategies.