Selective Serotonin Reuptake Inhibitor
Citalopram for Depression
The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with recent traumatic brain injury (TBI).
Melatonin Receptor Agonist
Ramelteon for Insomnia
This pilot study proposes to examine the effect of Rozerem on sleep/wake patterns among individuals with Traumatic Brain Injury (TBI) experiencing sleep disturbance, using both objective and subjective measures. It will also show that improvement in sleep/wake patterns resulting from Rozerem will impact daytime functioning using objective and subjective measures.
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Trials for Concussion Patients
Behavioral Intervention
ICARE Treatment for Traumatic Brain Injury
This trial tests a remote rehab program called ICARE to help people with brain injuries and their caregivers improve emotional understanding and relationships. It aims to teach them how to better recognize and respond to emotions, enhancing their relationship quality and emotional well-being.
Behavioural Intervention
Emotion & Attention Training for TBI and PTSD
This trial will test whether a multimodal affect recognition training (MMART), which includes training in both facial and vocal emotion recognition, can improve emotion recognition and attention in Veterans with mTBI and PTSD.
Anxiolytic
Buspirone for Traumatic Brain Injury Irritability and Aggression
This trial is testing buspirone, a medication usually used for anxiety, to see if it can help reduce irritability and aggression in people who have had a traumatic brain injury. The study involves 74 participants who will receive buspirone. The goal is to see if buspirone can make a positive difference in their behavior by calming the brain. Buspirone is a new anxiolytic agent that has been shown to reduce aggression and anxiety without causing sedation or cognitive side effects.
Behavioral Intervention
CLSI +3 More for Traumatic Brain Injury
This trial tests if specific teaching methods can help people with brain injuries learn better by matching their unique learning styles. It focuses on improving understanding and retention in an online science learning environment.
Trials for Traumatic Brain Injury Patients
Behavioral Intervention
ICARE Treatment for Traumatic Brain Injury
This trial tests a remote rehab program called ICARE to help people with brain injuries and their caregivers improve emotional understanding and relationships. It aims to teach them how to better recognize and respond to emotions, enhancing their relationship quality and emotional well-being.
Behavioural Intervention
Emotion & Attention Training for TBI and PTSD
This trial will test whether a multimodal affect recognition training (MMART), which includes training in both facial and vocal emotion recognition, can improve emotion recognition and attention in Veterans with mTBI and PTSD.
Anxiolytic
Buspirone for Traumatic Brain Injury Irritability and Aggression
This trial is testing buspirone, a medication usually used for anxiety, to see if it can help reduce irritability and aggression in people who have had a traumatic brain injury. The study involves 74 participants who will receive buspirone. The goal is to see if buspirone can make a positive difference in their behavior by calming the brain. Buspirone is a new anxiolytic agent that has been shown to reduce aggression and anxiety without causing sedation or cognitive side effects.
Behavioral Intervention
CLSI +3 More for Traumatic Brain Injury
This trial tests if specific teaching methods can help people with brain injuries learn better by matching their unique learning styles. It focuses on improving understanding and retention in an online science learning environment.
Trials With No Placebo
Behavioral Intervention
ICARE Treatment for Traumatic Brain Injury
This trial tests a remote rehab program called ICARE to help people with brain injuries and their caregivers improve emotional understanding and relationships. It aims to teach them how to better recognize and respond to emotions, enhancing their relationship quality and emotional well-being.
Opioid Analgesic
Morphine for Subarachnoid Hemorrhage
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood brain barrier. This loss results in the penetration into the brain of certain drugs that are normally excluded by the transporter protein. In this study the working hypothesis is that the agitation observed in patients with CNS trauma treated with morphine is related to the inflammation evoked loss of PGP in the blood brain barrier and the accumulation of the morphine metabolite 3-morphine glucuronide.
Behavioral Intervention
CLSI +3 More for Traumatic Brain Injury
This trial tests if specific teaching methods can help people with brain injuries learn better by matching their unique learning styles. It focuses on improving understanding and retention in an online science learning environment.
Hormone Therapy
NTx 265 for Traumatic Brain Injury
Prospective, Open Label, Cohort Study in Traumatic Brain Injury Patients. The goal of this study is to assess the safety of NTx®-265. NTx®-265 will be administered over 9 days, and patients will be followed for an additional 6 months.
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Frequently Asked Questions
Introduction to brain injury
What are the top hospitals conducting brain injury research?
When it comes to advancing the treatment and understanding of brain injuries, several prominent hospitals are leading the way. In Vancouver, Canada, Vancouver General Hospital is currently conducting four active clinical trials focused specifically on brain injuries. While they do not have any completed trials in this area as yet, their commitment to ongoing research demonstrates their dedication to finding new and improved strategies for addressing these complex conditions.
Similarly dedicated to the study of brain injury is the University of Texas Southwestern Medical Center in Dallas. With three active clinical trials underway, this esteemed institution is actively seeking innovative solutions for patients suffering from brain injuries. Although they also have no previous completed trials in this field, their current efforts hold promise for breakthroughs that can greatly impact patient outcomes.
In Ottawa, Canada's capital city, The Ottawa Hospital joins the ranks with three ongoing clinical trials centered around brain injury treatment and management. As a renowned medical facility committed to providing exceptional care and advancing medical knowledge through research initiatives, The Ottawa Hospital aims to enhance our understanding of brain injuries and improve patient outcomes through cutting-edge studies.
The Kessler Foundation located in West Orange has emerged as another important player in this field with three active clinical trials focusing solely on brain injury. Despite not having conducted any prior investigations into these conditions thus far, their current endeavors demonstrate an unwavering commitment towards exploring new avenues for diagnosis and treatment options that could revolutionize care delivery for individuals affected by debilitating brain injuries.
Finally making its mark within this realm is NYU Langone Health situated in New york City where two ongoing clinical tests geared primarily towards studying potential treatments targeting traumatic head trauma cases prevail; although none documented historic past experiments until now.Alongside other prestigious institutions specializing in neurological disorders throughout different parts of North America these hospitals pave ways toward improving diagnostic tools,treatment regimens,and overall prognosis bestowed upon those facing adversities arising due to traumatic or acquired disease-related incidents involving brains.While much work remains ahead,the combined efforts exemplify a fervent determination to unravel the complexities of brain injury and provide hope for those affected by these life-altering conditions.
Which are the best cities for brain injury clinical trials?
When it comes to brain injury clinical trials, several cities show promise as leaders in research and development. Dallas, Texas stands out with its 10 active trials focusing on innovative approaches like Active Transcranial direct current stimulation and Bilingual Brain Injury Education for Hispanic families. Vancouver, British Columbia follows closely behind with 8 ongoing studies exploring interventions such as guideline implementation tools and red blood cell transfusions. Lastly, Minneapolis, Minnesota showcases 7 active trials investigating treatments like the ketogenic diet and anodal transcranial direct current stimulation. These cities offer individuals affected by brain injuries access to cutting-edge clinical trials that strive towards improved outcomes and better quality of life.
Which are the top treatments for brain injury being explored in clinical trials?
Clinical trials are diving deep into finding effective treatments for brain injuries. Among the top contenders being explored, we have:
- NeuroAiD: showing promise in multiple studies
- Erythropoietin (EPO): demonstrating potential benefits in reducing brain damage
- Minocycline: currently under investigation for its neuroprotective properties
These treatments offer hope and possibilities for improving outcomes and quality of life for individuals with brain injuries. As research progresses, more breakthroughs may emerge to further revolutionize the field.
What are the most recent clinical trials for brain injury?
Exciting advancements in the field of brain injury research are providing hope for improved treatments and outcomes. One such recent clinical trial is investigating the potential benefits of active iTBS, a non-invasive brain stimulation technique, in individuals with brain injuries. Additionally, an intervention involving Atorvastatin calcium is being studied to assess its impact on brain injury patients. Another trial focuses on evaluating Group A as a possible treatment option for those affected by brain injuries. Furthermore, medical nutrition therapy is being explored as a complementary approach to enhance recovery in this patient population. Finally, Allopregnanolone has shown promise and is currently under investigation as a potential therapeutic intervention for individuals with brain injuries. These ongoing trials offer new possibilities and renewed hope for those who have experienced these challenging conditions.
What brain injury clinical trials were recently completed?
In the realm of brain injury research, a significant clinical trial was completed in September 2017. This trial, sponsored by Lindell Weaver, focused on investigating the potential benefits of Hyperbaric Oxygen therapy. While further recent trials may exist, this particular study sheds light on innovative approaches for addressing brain injuries and highlights ongoing efforts to advance treatment options in this field.