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Acoustic Stimuli for Spinal Cord Injury

Research Sponsored by Shirley Ryan AbilityLab
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 18-75 years
Chronic SCI (≥1 year of injury)
Screening 3 weeks
Treatment Varies
Follow Up 3-4 hours
Awards & highlights

Study Summary

This trial will help researchers understand how the body changes neurologically after a Spinal Cord Injury, which will in turn help patients with SCIs learn to live with their injury.

Who is the study for?
This trial is for adults aged 18-75 with chronic incomplete spinal cord injury at T12 or above, who've had the injury for over a year. Participants should be able to move their elbow, knee, or ankle voluntarily and grasp objects. It's not suitable for those with uncontrolled medical issues, major depression/psychosis before SCI, history of head injury/stroke/seizures, metal in the skull, pacemaker users, pregnant women or people on certain CNS drugs.Check my eligibility
What is being tested?
The study investigates how acoustic stimuli (Startle) can affect muscle stiffness (spasticity) after spinal cord injuries (SCI). The goal is to understand neurological recovery post-SCI and improve arm/hand function hindered by spasticity.See study design
What are the potential side effects?
Since this trial involves non-invasive acoustic stimuli rather than medication or surgery, significant side effects are not anticipated. However, participants may experience discomfort from startle responses.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am between 18 and 75 years old.
I have had a spinal cord injury for at least one year.
I have a partial spinal cord injury above my waist.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-4 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
10-meter walk test
Graded and Redefined Assessment of Strength, Sensibility and Prehension (GRASSP).
Ipsilateral MEPs (iMEPs)
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Aim 2Experimental Treatment1 Intervention
To accomplish this aim, we will use a randomized crossover design study with spastic SCI participants receiving a single intervention combining non-invasive acoustic stimuli (Startle) or sham-Startle with motor training to enhance cortico- and reticulo-spinal contribution, separated by ~2 weeks. Visit 1 and Visit 2 Single intervention of: Startle + exercise training OR sham-Startle + exercise training Pre and post measurements: MVCs MEP recruitment curves iMEPs StartReact Participant reported spasticity MAS PSAD KINARM Neuromechanical hand and/or leg testing GRASSP TRI-HFT 10-meter walk test Pendulum Test
Group II: Aim 1Experimental Treatment1 Intervention
To accomplish this aim, we will conduct one experiment in two sessions separated by 2- 3 days using a crossover design. Participants will be assigned into one of three groups: spastic SCI, non-spastic SCI, and controls. We expect that people enrolled in Aim 1 will complete 2 visits within 1 week. Visit 1 Measurements: MVCs MEP Recruitment Curves iMEPs StartReact Visit 2 Measurements: Participant Reported Spasticity MAS PSAD KINARM MRI of brain and spinal cord

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Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
193 Previous Clinical Trials
16,765 Total Patients Enrolled

Media Library

Acoustic stimuli (Startle) Clinical Trial Eligibility Overview. Trial Name: NCT04393922 — N/A
Spinal Cord Injury Research Study Groups: Aim 1, Aim 2
Spinal Cord Injury Clinical Trial 2023: Acoustic stimuli (Startle) Highlights & Side Effects. Trial Name: NCT04393922 — N/A
Acoustic stimuli (Startle) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04393922 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent is the sample size for this trial expanding?

"Indeed, according to clinicaltrials.gov this medical experiment is presently enrolling patients. This trial was posted on May 13th 2020 with its most recent update being June 20th 2022; 120 individuals are sought after at 1 site of the study."

Answered by AI

Is entry into this clinical trial restricted to individuals under twenty years old?

"This medical study only accepts participants aged 18 to 75. However, there are 157 trials for minors and 771 trials available for seniors."

Answered by AI

Is there still an opportunity for participants to join this research project?

"According to the database hosted on clinicaltrials.gov, this research project was initially posted in May of 2020 and since then has had edits made as recently as June 2022. At present, they are actively seeking participants."

Answered by AI

Could I partake in this scientific exploration if I meet the criteria?

"This clinical trial is enrolling 120 people aged 18-75 with spinal cord injuries, who meet the following requirements: An incomplete injury at T12 or higher on the American Spinal Injury Association Impairment Scale (AIS), AIS scores of 0 and 1 for spastic individuals, AIS scores 2, 3 and 4 for non-spastic individuals, The capacity to carry out voluntary flexion and extension of the elbow/knee/ankle."

Answered by AI
~24 spots leftby Apr 2025