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MRI Evaluation for Spinal Cord Injury (CHASM Trial)

N/A

Recruiting

Led By Brian Kwon, MD

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Acute tSCI injury involving bony spinal levels between C0 and T1

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up injury to 6 months post injury

Awards & highlights

CHASM Trial Summary

This trial will test whether drugs to raise blood pressure and prevent blood clots can improve outcomes for people with traumatic spinal cord injuries.

Who is the study for?

This trial is for adults aged 19 or older who have suffered a traumatic spinal cord injury between the base of the skull and top of the chest (C0-T1) and are admitted to the study site within a day. They must be able to consent and have certain levels of impairment. Those with MRI-incompatible devices, very high BMI, incomplete assessments, injuries from infection or cancer, or multiple severe injuries can't join.Check my eligibility

What is being tested?

The study uses MRI scans to see if treatments right after a spinal cord injury affect bleeding in the spine. It looks at two things: whether raising blood pressure with drugs (vasopressors) and preventing blood clots with anticoagulants influence hemorrhage during the first two weeks post-injury.See study design

What are the potential side effects?

MRI itself doesn't usually cause side effects but lying still in a scanner might be uncomfortable for some people. The focus here is on observing changes rather than direct side effects from interventions like vasopressors or anticoagulants.

CHASM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My spinal injury is between the base of my skull and the top of my mid-back.

CHASM Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ injury to 6 months post injury

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~injury to 6 months post injury

This trial's timeline: 3 weeks for screening, Varies for treatment, and injury to 6 months post injury for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hemorrhage Quantification 1

Hemorrhage Quantification 2

Hemorrhage Quantification 3

+1 more

Secondary outcome measures

Hemodynamic Management Assessment 1

Hemodynamic Management Assessment 2

Other outcome measures

Neurologic Assessments

CHASM Trial Design

1Treatment groups

Experimental Treatment

Group I: Arm 1Experimental Treatment1 Intervention

Serial MRI scans of patients with acute cervical SCI to quantify hemorrhage.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Magnetic resonance imaging (MRI)

2019

Completed Phase 4

~1080

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor

1,415 Previous Clinical Trials

2,466,992 Total Patients Enrolled

United States Department of DefenseFED

863 Previous Clinical Trials

227,608 Total Patients Enrolled

Brian Kwon, MDPrincipal InvestigatorUniversity of British Columbia

3 Previous Clinical Trials

130 Total Patients Enrolled

Media Library

Magnetic resonance imaging (MRI) Clinical Trial Eligibility Overview. Trial Name: NCT04758377 — N/A

Spinal Cord Hemorrhage Research Study Groups: Arm 1

Spinal Cord Hemorrhage Clinical Trial 2023: Magnetic resonance imaging (MRI) Highlights & Side Effects. Trial Name: NCT04758377 — N/A

Magnetic resonance imaging (MRI) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04758377 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants have been enlisted in this research endeavor?

"Confirmed. Per the clinicaltrials.gov records, this clinical trial has been open for recruitment since February 6th 2021 and was last updated on February 7th 2022. 24 participants are needed to be recruited from 1 site location."

Answered by AI

Is enrollment currently open for this research endeavor?

"According to the clinicaltrials.gov listing, this study is currently in search of participants. It was first published on February 6th 2021 and underwent its most recent revision a year later on February 7th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI

Brian Kwon 2021. "Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04758377.

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