Ibuprofen for Epilepsy

Phase-Based Progress Estimates
South Health Campus, Calgary, CanadaEpilepsy+1 MoreIbuprofen - Drug
Any Age
All Sexes
What conditions do you have?

Study Summary

This trial will see if ibuprofen or nifedipine can help with post-seizure issues like reduced blood flow to the brain and neurological problems.

Eligible Conditions
  • Epilepsy
  • Partial Epilepsy

Treatment Effectiveness

Study Objectives

1 Primary · 11 Secondary · Reporting Duration: 5 - 40 days

5 - 40 days
Negative affect
Neuropsychological performance - Dimensional Change Card Sort Test
Neuropsychological performance - Flanker Inhibitory Control and Attention Test
Neuropsychological performance - List Sorting Working Memory Test
Neuropsychological performance - Pattern Comparison Processing Speed Test
Neuropsychological performance - Picture Sequence Memory Test
Neuropsychological performance - Picture Vocabulary Test
Neuropsychological performance- Oral Reading Recognition Test
Postictal blood flow
Psychological well-being
Social Relationships
Stress and Self-Efficacy Relationships

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

3 Treatment Groups

1 of 3
1 of 3
1 of 3

Experimental Treatment

Non-Treatment Group

90 Total Participants · 3 Treatment Groups

Primary Treatment: Ibuprofen · Has Placebo Group · Phase 2

Experimental Group · 1 Intervention: Nifedipine · Intervention Types: Drug
Experimental Group · 1 Intervention: Ibuprofen · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 5 - 40 days

Who is running the clinical trial?

University of CalgaryLead Sponsor
721 Previous Clinical Trials
574,469 Total Patients Enrolled
3 Trials studying Epilepsy
357 Patients Enrolled for Epilepsy
Paolo Federico, MD, PhDPrincipal InvestigatorUniversity of Calgary

Eligibility Criteria

Age Any Age · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You experience seizures more than once a week.
You are able to understand and complete cognitive tests.

Frequently Asked Questions

Can you discuss other experiments conducted with Ibuprofen?

"At present, there are 53 studies examining the efficacy of Ibuprofen in operation. 13 of these trials have progressed to Phase 3 and 173 medical sites across the country have opened their doors for participation. Most notably, Pittsburgh Pennsylvania is a hub for investigations into this drug." - Anonymous Online Contributor

Unverified Answer

What risks have been associated with Ibuprofen consumption?

"Our team at Power assessed Ibuprofen's safety with a score of 2, indicating that there is some empirical data demonstrating its security but no proof of efficacy yet." - Anonymous Online Contributor

Unverified Answer

Is there availability for participants in this clinical experiment?

"Clinicaltrials.gov currently states that this medical trial is open for enrollment, with the initial posting having occurred on February 1st 2021 and a recent edit occurring November 15th 2022." - Anonymous Online Contributor

Unverified Answer

Is this a pioneering clinical trial?

"Clinicialtrials.gov has identified 53 live studies with Ibuprofen across 92 cities and 17 nations, beginning in 2007 when Encysive Pharmaceuticals conducted a Phase 2 drug approval involving 27 participants. Since then, 18675 have been completed successfully." - Anonymous Online Contributor

Unverified Answer

What conditions does Ibuprofen commonly address?

"Ibuprofen is the most popular treatment for catarrh, and it can also assist with muscle spasms, early labor, and pulmonary hypertension." - Anonymous Online Contributor

Unverified Answer

How many patients have signed up for participation in this medical experiment?

"Affirmative. Clinicaltrials.gov data confirms that this clinical trial is currently enrolling participants, with the first post being made on February 1st 2021 and last edited on November 15th 2022. 90 patients need to be enrolled from two distinct medical sites." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.