Study Summary
This trial will help researchers understand how the brain processes speech, which could lead to new treatments for speech disorders.
Eligible Conditions
- Language Disorder
- Epilepsy
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 0 Secondary · Reporting Duration: Throughout intracranial monitoring period, up to approximately 10 days
Day 10
Brain scores for diverse artificial neural network (ANN) language models
Cortical maps of linguistic responses
Neural time-courses during naturalistic language comprehension
Trial Safety
Safety Progress
Trial Design
0 Treatment Group
40 Total Participants · 0 Treatment Group
Primary Treatment: Treatment · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: throughout intracranial monitoring period, up to approximately 10 days
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,725 Previous Clinical Trials
31,219,257 Total Patients Enrolled
Massachusetts Institute of TechnologyOTHER
87 Previous Clinical Trials
18,351,250 Total Patients Enrolled
Eligibility Criteria
Age 18 - 85 · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:A team of doctors specializing in epilepsy surgery has determined that you need monitoring inside your brain on the left side.
References
- Siegelman, Matthew, Idan A. Blank, Zachary Mineroff, and Evelina Fedorenko. 2019. “An Attempt to Conceptually Replicate the Dissociation Between Syntax and Semantics During Sentence Comprehension”. Neuroscience. Elsevier BV. doi:10.1016/j.neuroscience.2019.06.003.
- Fedorenko, Evelina, Alfonso Nieto-Castañon, and Nancy Kanwisher. 2012. “Lexical and Syntactic Representations in the Brain: An Fmri Investigation with Multi-voxel Pattern Analyses”. Neuropsychologia. Elsevier BV. doi:10.1016/j.neuropsychologia.2011.09.014.
- Mollica, F., Siegelman, M., Diachek, E., Piantadosi, S. T., Mineroff, Z., Futrell, R., Kean, H.,Qian, P., & Fedorenko, E. (2020). Composition is the Core Driver of the Language-selective Network. Neurobiology of Language, 1(1), 104-134. https://doi.org/10.1162/nol_a_00005
- Pereira, Francisco, Bin Lou, Brianna Pritchett, Samuel Ritter, Samuel J. Gershman, Nancy Kanwisher, Matthew Botvinick, and Evelina Fedorenko. 2018. “Toward a Universal Decoder of Linguistic Meaning from Brain Activation”. Nature Communications. Springer Science and Business Media LLC. doi:10.1038/s41467-018-03068-4.
- Fedorenko, Evelina, and Idan A. Blank. 2020. “Broca’s Area Is Not a Natural Kind”. Trends in Cognitive Sciences. Elsevier BV. doi:10.1016/j.tics.2020.01.001.
- Fedorenko, Evelina, John Duncan, and Nancy Kanwisher. 2012. “Language-selective and Domain-general Regions Lie Side by Side Within Broca’s Area”. Current Biology. Elsevier BV. doi:10.1016/j.cub.2012.09.011.
- Fedorenko, Evelina, Po-Jang Hsieh, Alfonso Nieto-Castañón, Susan Whitfield-Gabrieli, and Nancy Kanwisher. 2010. “New Method for Fmri Investigations of Language: Defining Rois Functionally in Individual Subjects”. Journal of Neurophysiology. American Physiological Society. doi:10.1152/jn.00032.2010.
- Blank, Idan A., and Evelina Fedorenko. 2020. “No Evidence for Differences Among Language Regions in Their Temporal Receptive Windows”. Neuroimage. Elsevier BV. doi:10.1016/j.neuroimage.2020.116925.
- Fedorenko, Evelina, Terri L. Scott, Peter Brunner, William G. Coon, Brianna Pritchett, Gerwin Schalk, and Nancy Kanwisher. 2016. “Neural Correlate of the Construction of Sentence Meaning”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1612132113.
- Fedorenko, Evelina, Michael K. Behr, and Nancy Kanwisher. 2011. “Functional Specificity for High-level Linguistic Processing in the Human Brain”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1112937108.
- Norman-Haignere, Sam, Nancy G. Kanwisher, and Josh H. McDermott. 2015. “Distinct Cortical Pathways for Music and Speech Revealed by Hypothesis-free Voxel Decomposition”. Neuron. Elsevier BV. doi:10.1016/j.neuron.2015.11.035.
- Blank, Idan, Zuzanna Balewski, Kyle Mahowald, and Evelina Fedorenko. 2016. “Syntactic Processing Is Distributed Across the Language System”. Neuroimage. Elsevier BV. doi:10.1016/j.neuroimage.2015.11.069.
- Shain, Cory, Idan Asher Blank, Marten van Schijndel, William Schuler, and Evelina Fedorenko. 2020. “Fmri Reveals Language-specific Predictive Coding During Naturalistic Sentence Comprehension”. Neuropsychologia. Elsevier BV. doi:10.1016/j.neuropsychologia.2019.107307.
- Nieto-Castañón, Alfonso, and Evelina Fedorenko. 2012. “Subject-specific Functional Localizers Increase Sensitivity and Functional Resolution of Multi-subject Analyses”. Neuroimage. Elsevier BV. doi:10.1016/j.neuroimage.2012.06.065.
- Fedorenko E, Scott TL, Brunner P, Coon WG, Pritchett B, Schalk G, Kanwisher N. Neural correlate of the construction of sentence meaning. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6256-E6262. doi: 10.1073/pnas.1612132113. Epub 2016 Sep 26.
- Fedorenko E, Nieto-Castanon A, Kanwisher N. Lexical and syntactic representations in the brain: an fMRI investigation with multi-voxel pattern analyses. Neuropsychologia. 2012 Mar;50(4):499-513. doi: 10.1016/j.neuropsychologia.2011.09.014. Epub 2011 Sep 17.
- Fedorenko E, Blank IA. Broca's Area Is Not a Natural Kind. Trends Cogn Sci. 2020 Apr;24(4):270-284. doi: 10.1016/j.tics.2020.01.001. Epub 2020 Feb 20.
- Nieto-Castanon A, Fedorenko E. Subject-specific functional localizers increase sensitivity and functional resolution of multi-subject analyses. Neuroimage. 2012 Nov 15;63(3):1646-69. doi: 10.1016/j.neuroimage.2012.06.065. Epub 2012 Jul 8.
- Fedorenko E, Hsieh PJ, Nieto-Castanon A, Whitfield-Gabrieli S, Kanwisher N. New method for fMRI investigations of language: defining ROIs functionally in individual subjects. J Neurophysiol. 2010 Aug;104(2):1177-94. doi: 10.1152/jn.00032.2010. Epub 2010 Apr 21.
- Robert Mark Richardson 2021. "Computational Neuroscience of Language Processing in the Human Brain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05222594.
Frequently Asked Questions
What is the total number of participants being included in this clinical research?
"Affirmative. The information on clinicaltrials.gov attests to this medical trial's active recruitment of participants, which commenced on April 2nd 2021 and was recently updated February 10th 2022. This research project needs 40 people to be recruited at a single location." - Anonymous Online Contributor
Unverified Answer
Does your research accept participants aged 55 and over?
"To be eligible for this trial, applicants must fall within the age range of 18 and 85. Additionally, 106 studies are recruiting participants younger than 18 years old whereas 160 trials seek those older than 65." - Anonymous Online Contributor
Unverified Answer
Who qualifies to become an enrollee in this experiment?
"In order to be considered, applicants must possess the capacity for language and meet age criteria (18-85). This study is looking to accept a total of 40 individuals." - Anonymous Online Contributor
Unverified Answer
Is enrollment currently open for the trial?
"Indeed, the information found on clinicaltrials.gov reveals that this research is currently accepting enrollees. Initially posted on April 2nd 2021 and recently amended at February 10th 2022, 40 patients are sought from a single location." - Anonymous Online Contributor
Unverified Answer