← Back to Search

Alcohol Effects on Brain Activity During Intoxication

Phase 2

Recruiting

Led By Emil Coccaro, M.D.

Research Sponsored by Ohio State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

21 to 55 years of age (and be right-handed) and not a current (past 3 months) alcohol abstainer.

Physically healthy (confirmed by comprehensive medical history and physical exam) and does not have metal implants, plates, or screws in body or head (MRI safety issue).

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 60-120 minutes after ethanol (or placebo) drink

Awards & highlights

Study Summary

This trial aims to understand how alcohol affects brain activity related to aggressive behavior in people with and without Alcohol Use Disorder and Impulsive Aggression. It could lead to better interventions to reduce alcohol-related violence.

Who is the study for?

This trial is for right-handed adults aged 21-55 who may or may not have a history of aggressive outbursts and alcohol use disorder (AUD), but no major psychiatric disorders, significant medical conditions, or high psychopathy scores. Smokers must limit to 15 cigarettes per day. Participants should be able to abstain from alcohol for 24 hours and drugs for 48 hours before MRI scans.Check my eligibility

What is being tested?

The study tests how brain activity related to social-emotional information processing changes after drinking alcohol versus a placebo. It involves fMRI imaging in individuals with varying levels of aggression and AUD to identify potential intervention targets that could reduce alcohol-related aggression.See study design

What are the potential side effects?

While the trial primarily uses alcohol which can cause intoxication leading to impaired judgment, coordination issues, mood swings, and potentially aggressive behavior; there are no additional side effects listed as it compares against a placebo.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 21 and 55 years old, right-handed, and have consumed alcohol in the last 3 months.

Select...

I am physically healthy and do not have any metal implants, plates, or screws in my body.

Select...

My aggression score is above 12.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 60-120 minutes after ethanol (or placebo) drink

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~60-120 minutes after ethanol (or placebo) drink

This trial's timeline: 3 weeks for screening, Varies for treatment, and 60-120 minutes after ethanol (or placebo) drink for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain Connectivity

Cortico-limbic Response to Anger Faces

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Oral alcohol drinkExperimental Treatment1 Intervention

Group II: Placebo (non-alcohol drink)Placebo Group1 Intervention

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ohio State UniversityLead Sponsor

830 Previous Clinical Trials

505,476 Total Patients Enrolled

2 Trials studying Alcoholism

210 Patients Enrolled for Alcoholism

National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIH

802 Previous Clinical Trials

1,365,301 Total Patients Enrolled

424 Trials studying Alcoholism

985,724 Patients Enrolled for Alcoholism

Emil Coccaro, M.D.Principal InvestigatorThe Ohio State University Wexner Medical Center

1 Previous Clinical Trials

50 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the maximum capacity for enrolment in this clinical trial?

"Affirmative. Clinicaltrials.gov exhibits that this medical trial, which was originally posted on 8th June 2023, is currently looking for patients. In total 144 participants must be enrolled from 1 site."

Answered by AI

Are there any open enrollments for this clinical investigation?

"According to the clinicaltrials.gov website, this medical trial is actively looking for patients and was last updated on November 1st 2023. Recruitment began on June 8th of the same year."

Answered by AI

Is imbibing alcoholic beverages sanctioned by the FDA?

"Oral alcohol drink was assessed to be a 2 on the safety scale due to the presence of data connoting its security, yet there is no evidence that it has any efficacy."

Answered by AI

Am I eligible to join this medical research?

"This clinical trial is in search of 144 individuals with an alcohol dependence, aged between 21 and 55."

Answered by AI

To what extent are individuals below the age of seventy eligible for this scientific experiment?

"This trial is specifically designed for patients aged 21 to 55, and there are 20 clinical trials for those under 18 years old while 214 studies target elderly individuals."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Neural Correlates During Alcohol Intoxication

Emil Coccaro 2023. "Neural Correlates During Alcohol Intoxication". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06118580.