Virtual Reality Exposure Therapy for Epilepsy-related Anxiety
(AnxEMU Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether virtual reality exposure therapy (VR-ET) can reduce anxiety in people with epilepsy who experience anxiety between seizures. Researchers aim to determine if VR therapy makes a difference and if participants find the process easy to follow. Participants will either receive VR-ET or play a neutral VR game for up to 10 days. Those admitted to an epilepsy monitoring unit and reporting anxiety related to epilepsy or seizures might be suitable for this trial. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new anxiety management strategies for epilepsy.
Do I need to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications. However, if you have started an antidepressant, antianxiety drug, or medical marijuana in the last twelve weeks, you cannot participate.
What prior data suggests that Virtual Reality Exposure Therapy is safe for people with epilepsy-related anxiety?
Research has shown that Virtual Reality Exposure Therapy (VR-ET) is generally safe for treating anxiety disorders such as phobias and post-traumatic stress disorder. Other studies found that people with epilepsy also tolerated VR-ET well, with no severe side effects reported. This therapy uses a VR headset to create a controlled setting, reducing anxiety through repeated exposure. As VR-ET involves no physical procedures and has been safely tested in similar contexts, it appears to be a safe option.12345
Why are researchers excited about this trial?
Researchers are excited about Virtual Reality Exposure Therapy (VR-ET) for epilepsy-related anxiety because it offers a unique, immersive approach that differs from traditional methods like medication or cognitive behavioral therapy. Unlike standard treatments, VR-ET provides a controlled, virtual environment where individuals can safely confront and manage their anxiety triggers in real-time. This method not only makes therapy more engaging and interactive but also has the potential to deliver quicker results by allowing patients to experience and practice coping strategies in a realistic yet controlled setting. Additionally, the neutral game used in the comparison group helps understand how different types of virtual experiences might affect anxiety, potentially leading to more personalized treatment options.
What evidence suggests that Virtual Reality Exposure Therapy is effective for epilepsy-related anxiety?
Research has shown that Virtual Reality Exposure Therapy (VR-ET), which participants in this trial may receive, can help lower anxiety in people with epilepsy. One study found that 71% of participants felt the VR scenarios resembled their real-life anxiety triggers, indicating that the therapy effectively targets anxiety. VR-ET has also successfully treated other anxiety issues, such as phobias and PTSD (post-traumatic stress disorder). These early results suggest that VR-ET might effectively reduce anxiety related to epilepsy. Meanwhile, another group in this trial will use a VR device with a "neutral" game, serving as an active comparator.12346
Who Is on the Research Team?
Esther Bui
Principal Investigator
University Health Network, Toronto
Are You a Good Fit for This Trial?
This trial is for adults with epilepsy admitted to the EMU who experience anxiety related to their condition. They must not have photosensitive epilepsy, recent changes in certain medications, or conditions that prevent safe VR headset use.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete baseline questionnaires on anxiety, depression, avoidance behaviours, and quality of life. They are also shown a neutral video with the VR device to check for motion sickness.
Intervention
Participants use the VR system twice a day for up to 10 days, with each session lasting approximately 5 minutes. Anxiety and motion sickness are assessed before and after each session.
Post-Intervention Assessment
Participants repeat baseline questionnaires and complete additional questionnaires on VR usability and sense of presence. A short interview is conducted to discuss their experience.
1-Month Follow-up
A follow-up phone interview is conducted, and participants repeat baseline questionnaires about anxiety, depression, avoidance behaviours, and quality of life.
What Are the Treatments Tested in This Trial?
Interventions
- Virtual Reality Exposure Therapy
Virtual Reality Exposure Therapy is already approved in United States for the following indications:
- Posttraumatic Stress Disorder (PTSD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Health Network, Toronto
Lead Sponsor