Acoustic Stimulation for Epilepsy
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you do not change your medications for at least 1 month before and during the 3 months of study activities. However, if you are taking psychoactive medications (like SSRIs, antipsychotics, or stimulants), you cannot participate in the trial.
What data supports the effectiveness of the treatment Acoustic 1Hz Stimulation, Sham Background Noise for epilepsy?
Is acoustic stimulation safe for humans?
The research primarily involves animal studies, which show that high-intensity sound can induce seizures in seizure-prone rats and mice. While these studies do not directly address human safety, they suggest caution when using high-intensity acoustic stimulation, especially in individuals with seizure susceptibility.16789
How does Acoustic 1Hz Stimulation differ from other epilepsy treatments?
Acoustic 1Hz Stimulation is unique because it uses sound to potentially reduce seizure frequency and duration by delivering specific auditory stimuli during epileptic activity, unlike traditional treatments that often involve medication. This approach is non-invasive and leverages the brain's response to sound, offering a novel way to manage seizures without the side effects associated with drugs.14101112
What is the purpose of this trial?
The objective of this study is to test the feasibility and physiological effect of low-frequency (1 Hz) acoustic stimulation delivered during nocturnal NREM sleep in epilepsy patients. The long-term goal is to develop this protocol for daily, long-term use in a home setting, for nocturnal seizure and IED suppression
Research Team
Anli Liu
Principal Investigator
NYU Langone Health
Eligibility Criteria
This trial is for adults aged 18-60 with epilepsy, who experience frequent nocturnal seizures or disturbances in their sleep due to seizure activity. Participants should be fluent in English, have a good cognitive function (MOCA score ≥26), and not be overweight (BMI <30). They shouldn't have hearing issues, sleep disorders, recent travel across time zones, shift work history before the study, or use certain psychoactive medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Monitoring
No use of sound system; patients record seizures in a diary
Treatment
1 Hz acoustic stimulation applied via headphones during sleep every night
Sham Comparator
Background noise applied via headphones during sleep every night
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Acoustic 1Hz Stimulation
- Sham Background Noise
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor