Dietary Fats for Vascular Health
(PPMS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal. Previous studies have found that monocytes are important for blood vessel health. In this study, two different high-fat meals will be used to study the effect of different types of dietary fat on postprandial NCMs. The investigators will characterize NCMs in both fasting conditions and following consumption of two different high-fat meals, and will evaluate whether the type of fat in a meal affects NCMs in blood.
Who Is on the Research Team?
Ryan Snodgrass, PhD
Principal Investigator
USDA, Western Human Nutrition Research Center
Are You a Good Fit for This Trial?
This study is for healthy adults aged 18-39 with a BMI of 18.5 to 29.9, who have no allergies to meal ingredients and no chronic diseases requiring daily medication. Participants must not be on certain medications, pregnant, or have recent surgeries or hospitalizations.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume one of two isocaloric high-fat challenge meals spaced two weeks apart, with blood samples collected at fasting and 6 hours postprandial
Follow-up
Participants are monitored for changes in monocyte subsets and other blood parameters after meal consumption
What Are the Treatments Tested in This Trial?
Interventions
- High mono unsaturated fat challenge meal
- High saturated fat challenge meal
Find a Clinic Near You
Who Is Running the Clinical Trial?
USDA, Western Human Nutrition Research Center
Lead Sponsor