32 Participants Needed

Dietary Fats for Vascular Health

(PPMS Trial)

RS
EB
Overseen ByEllen Bonnel, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: USDA, Western Human Nutrition Research Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal. Previous studies have found that monocytes are important for blood vessel health. In this study, two different high-fat meals will be used to study the effect of different types of dietary fat on postprandial NCMs. The investigators will characterize NCMs in both fasting conditions and following consumption of two different high-fat meals, and will evaluate whether the type of fat in a meal affects NCMs in blood.

Who Is on the Research Team?

RS

Ryan Snodgrass, PhD

Principal Investigator

USDA, Western Human Nutrition Research Center

Are You a Good Fit for This Trial?

This study is for healthy adults aged 18-39 with a BMI of 18.5 to 29.9, who have no allergies to meal ingredients and no chronic diseases requiring daily medication. Participants must not be on certain medications, pregnant, or have recent surgeries or hospitalizations.

Inclusion Criteria

BMI 18.5 - 29.9 kg/m²
Must have a bank account and social security number or taxpayer identification for financial compensation

Exclusion Criteria

Triglycerides above 150 mg/dL
Unable to fast for 12 hours
Fasting glucose above 105 mg/dL
See 17 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume one of two isocaloric high-fat challenge meals spaced two weeks apart, with blood samples collected at fasting and 6 hours postprandial

4 weeks
2 visits (in-person)

Follow-up

Participants are monitored for changes in monocyte subsets and other blood parameters after meal consumption

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • High mono unsaturated fat challenge meal
  • High saturated fat challenge meal
Trial Overview The trial investigates how two high-fat meals (one rich in saturated fat and the other in mono unsaturated fat) affect immune cells called non-classical monocytes after eating. The focus is on these cells' role in blood vessel health post-meal.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: High saturated fat challenge meal followed by high mono-unsaturated fat challenge mealExperimental Treatment2 Interventions
Group II: High mono-unsaturated fat challenge meal followed by high saturated fat challenge mealExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

USDA, Western Human Nutrition Research Center

Lead Sponsor

Trials
64
Recruited
19,100+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security