32 Participants Needed

Dietary Fats for Vascular Health

(PPMS Trial)

RS
EB
Overseen ByEllen Bonnel, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: USDA, Western Human Nutrition Research Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal. Previous studies have found that monocytes are important for blood vessel health. In this study, two different high-fat meals will be used to study the effect of different types of dietary fat on postprandial NCMs. The investigators will characterize NCMs in both fasting conditions and following consumption of two different high-fat meals, and will evaluate whether the type of fat in a meal affects NCMs in blood.

Research Team

RS

Ryan Snodgrass, PhD

Principal Investigator

USDA, Western Human Nutrition Research Center

Eligibility Criteria

This study is for healthy adults aged 18-39 with a BMI of 18.5 to 29.9, who have no allergies to meal ingredients and no chronic diseases requiring daily medication. Participants must not be on certain medications, pregnant, or have recent surgeries or hospitalizations.

Inclusion Criteria

BMI 18.5 - 29.9 kg/m²
Must have a bank account and social security number or taxpayer identification for financial compensation

Exclusion Criteria

Triglycerides above 150 mg/dL
Unable to fast for 12 hours
Fasting glucose above 105 mg/dL
See 18 more

Treatment Details

Interventions

  • High mono unsaturated fat challenge meal
  • High saturated fat challenge meal
Trial OverviewThe trial investigates how two high-fat meals (one rich in saturated fat and the other in mono unsaturated fat) affect immune cells called non-classical monocytes after eating. The focus is on these cells' role in blood vessel health post-meal.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: High saturated fat challenge meal followed by high mono-unsaturated fat challenge mealExperimental Treatment2 Interventions
High saturated fat mixed macronutrient challenge meal with palm oil followed by high mono-unsaturated fat mixed macronutrient challenge meal with olive oil two weeks later
Group II: High mono-unsaturated fat challenge meal followed by high saturated fat challenge mealExperimental Treatment2 Interventions
High mono-unsaturated fat mixed macronutrient challenge meal with olive oil followed by high saturated fat mixed macronutrient challenge meal with palm oil two weeks later

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Who Is Running the Clinical Trial?

USDA, Western Human Nutrition Research Center

Lead Sponsor

Trials
64
Recruited
19,100+