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Active Direct electrical stimulation (DES) for Epilepsy

N/A

Recruiting

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age range between 18 and 65

Major depressive disorder (MDD) in a current major depressive episode diagnosed with the Mini-International Neuropsychiatric Interview (MINI)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 minutes

Awards & highlights

Study Summary

This trial aims to show that video-based measures of audio and facial behaviors can provide an objective, continuous measure of internal mood.

Who is the study for?

This trial is for adults aged 18-65 with Major Depressive Disorder currently experiencing a depressive episode. Participants must understand the study and consent independently, without medical or surgical reasons preventing electrode implantation. It's not suitable for those with diffuse epilepsy affecting multiple brain lobes.Check my eligibility

What is being tested?

The study tests if audio-facial behaviors captured on video can reliably indicate mood states by correlating them with neural activity via intracranial electrodes. This could lead to better remote monitoring of mood in clinical and home settings.See study design

What are the potential side effects?

While specific side effects are not listed, intracranial electrode placement involves risks such as infection, bleeding, or damage to brain tissue which may result in neurological symptoms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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I have been diagnosed with major depression currently.

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I have no health issues preventing me from getting an electrode implant.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Quantitative Audio-Facial Change

Quantitative Mood Change

Secondary outcome measures

Correlation between Audio-Facial and Mood Change

Qualitative Mood Change

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Active Direct electrical stimulation (DES)Active Control1 Intervention

Intracranial electrodes will be used for the delivery of invasive brain stimulation.

Group II: Sham Direct electrical stimulation (DES)Placebo Group1 Intervention

Intracranial electrodes will be used for the delivery of invasive brain stimulation.

0 / 3Eligibility criteria met

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Who is running the clinical trial?

Stanford UniversityLead Sponsor

2,395 Previous Clinical Trials

17,341,340 Total Patients Enrolled

16 Trials studying Epilepsy

1,248 Patients Enrolled for Epilepsy

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it currently possible to join this clinical experiment?

"Unfortunately, this clinical trial is no longer recruiting patients. Initially posted in December 1st 2023 and last updated on the 4th of the same month, it has been superseded by 1110 other trials that are currently seeking candidates."

Answered by AI

Could I potentially be accepted into this research project?

"Criteria for inclusion in this clinical trial necessitates that applicants suffer from epilepsy and be within the specified age range. The researchers are seeking approximately 10 participants."

Answered by AI

Is this medical trial open to participants aged sixty and above?

"The bounds of eligibility for this medical trial are those aged 18 to 65. In addition, there are 220 trials aimed at people younger than the age of majority and 787 focused on seniors over the age of retirement."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Behavioral and Neuronal Correlates of Human Mood States

Corey Keller 2023. "Behavioral and Neuronal Correlates of Human Mood States". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06159595.

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