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Bone Marrow Aspiration for Kidney Transplant Rejection

N/A

Recruiting

Led By Mark Stegall, MD

Research Sponsored by Mark Stegall

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pre or post renal transplant recipients who are 'sensitized', having allo antibodies as evidenced by single antigen bead analysis

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post bone marrow collection

Awards & highlights

Study Summary

This trial is testing whether two different tests can show why patients who have had a kidney transplant and have developed antibodies against their donor are at a greater risk for their transplanted organ being rejected.

Who is the study for?

This trial is for kidney transplant recipients with antibodies against their donors (sensitized) and the living donors themselves. Participants must consent to study procedures not part of normal care. Excluded are those with low neutrophil or platelet counts, recent investigational drug use, current systemic anticoagulation therapy, certain cancer histories within 5 years, or serious medical/psychiatric conditions.Check my eligibility

What is being tested?

The study tests the validity of two assays on bone marrow from sensitized kidney transplant recipients to understand the higher rejection risk in these patients. It involves marrow aspirations from both recipients and living donors to assess immune responses.See study design

What are the potential side effects?

While specific side effects are not listed for bone marrow aspirations in this summary, common ones include pain at the aspiration site, bleeding, bruising, and infection risk.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have antibodies against a kidney transplant as shown by a specific test.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ post bone marrow collection

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~post bone marrow collection

This trial's timeline: 3 weeks for screening, Varies for treatment, and post bone marrow collection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

To determine the variability of the AlloElispot and Allospecificities assay.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Sensitized Renal Allograft RecipientsExperimental Treatment1 Intervention

Patients who have antibodies against their donors in their blood.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mark StegallLead Sponsor

3 Previous Clinical Trials

1,235 Total Patients Enrolled

Mayo ClinicLead Sponsor

3,210 Previous Clinical Trials

3,766,473 Total Patients Enrolled

National Institute of Allergy and Infectious Diseases (NIAID)NIH

3,269 Previous Clinical Trials

5,480,981 Total Patients Enrolled

Media Library

bone marrow aspirations Clinical Trial Eligibility Overview. Trial Name: NCT01150487 — N/A

Kidney Transplant Research Study Groups: Sensitized Renal Allograft Recipients

Kidney Transplant Clinical Trial 2023: bone marrow aspirations Highlights & Side Effects. Trial Name: NCT01150487 — N/A

bone marrow aspirations 2023 Treatment Timeline for Medical Study. Trial Name: NCT01150487 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study allow minors to participate?

"This medical study is seeking participants aged 18 and above, but younger than 99."

Answered by AI

What criteria must individuals meet to be considered eligible for this research project?

"This trial is seeking 80 individuals between 18 and 99 years of age with a history of kidney-related issues. Applicants must also have pre or post renal transplants, be sensitized as indicated by single antigen bead analysis, qualify as potential donors for renal transplantation, sign informed consent forms prior to any study procedures outside normal medical care, and understand that they may withdraw their participation at any time without repercussions."

Answered by AI

How many participants are presently approved for this trial?

"Affirmative. The information found on clinicaltrials.gov indicates that recruitment is still in progress for this research project, which first appeared online on June 1st 2010 and most recently was edited on May 19th 2022. 80 individuals are needed from one medical centre to complete the study."

Answered by AI

Are there any openings to join this medical research study?

"Absolutely. Clinicaltrials.gov confirms that this medical experiment, which was initially posted on June 1st 2010, is still recruiting participants. This trial requires 80 patient from a single location to participate in the study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients

Mark Stegall 2010. "Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01150487.

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