170 Participants Needed

Cognitive Intervention for Epilepsy

AL
Overseen ByAnthony Lioi, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Kayela Arrotta
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It seems focused on cognitive interventions, so it's likely you can continue your current treatment, but you should confirm with the study team.

What data supports the effectiveness of the treatment Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E, Lifestyle Interventions for Epilepsy?

Research shows that cognitive interventions, like memory enhancement courses and cognitive behavioral therapy, can improve memory, attention, and quality of life in people with epilepsy. These treatments help manage cognitive difficulties and improve mood, which are common challenges for those with epilepsy.12345

Is the Cognitive Intervention for Epilepsy safe for humans?

The studies on cognitive interventions for epilepsy, such as memory enhancement courses and psychoeducational programs, do not report any safety concerns, suggesting they are generally safe for humans.12567

How is the Cognitive Enhancement Intervention treatment for epilepsy different from other treatments?

The Cognitive Enhancement Intervention for epilepsy is unique because it focuses on improving cognitive abilities, quality of life, and self-management through psychological and behavioral strategies, rather than directly targeting seizures like traditional drug treatments.12458

What is the purpose of this trial?

This trial tests if online group sessions led by a brain health expert can help people with epilepsy improve their thinking and memory skills. Participants will join regular sessions for a few months and then practice on their own for several more months. The goal is to see if these mental exercises can enhance daily functioning and overall brain health.

Research Team

KA

Kayela Arrotta, PhD

Principal Investigator

The Cleveland Clinic

Eligibility Criteria

Adults aged 18-60 with diagnosed epilepsy, fluent in English, and able to consent can join. They must have internet access for online sessions and no history of epilepsy surgery. Excluded are those with serious psychiatric conditions or intensive medical treatments, recent pregnancy/postpartum, significant sensory loss, prior cognitive rehab within 6 months, or pending epilepsy surgery.

Inclusion Criteria

I have never had surgery for epilepsy.
Potential patients will be identified if they have been, or are scheduled to be seen, either in-person or virtually for a clinical visit within the Cleveland Clinic Epilepsy Center
Fluent in English
See 5 more

Exclusion Criteria

I am currently receiving intense treatment for a serious illness that may affect my participation in the study.
I am scheduled for epilepsy surgery within the next 6 months.
Currently pregnant or less than 6 weeks postpartum
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Cognitive Intervention

Participants receive weekly, live, virtual group sessions led by a neuropsychologist for 12 weeks

12 weeks
12 visits (virtual)

Self-study

Participants practice what they learned during the intervention for 9 months

9 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

Treatment Details

Interventions

  • Cognitive Enhancement Intervention
Trial Overview The trial tests if weekly virtual cognitive intervention sessions led by a neuropsychologist over 12 weeks plus continued practice for 9 months can improve brain health in people with epilepsy. Participants' progress is compared to others who don't receive the intervention.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive InterventionExperimental Treatment1 Intervention
Participants in this group will receive weekly, live, virtual group sessions for 12 weeks
Group II: ControlActive Control1 Intervention
Participants in this group will NOT receive the group sessions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kayela Arrotta

Lead Sponsor

Trials
2
Recruited
230+

Findings from Research

A 1-hour memory enhancement course for 39 individuals with epilepsy led to significant and sustained improvements in cognitive abilities and self-management skills, as assessed at multiple follow-up points.
While the course was well-received by participants, it did not result in improvements in quality of life or seizure severity, indicating that while cognitive support is beneficial, it may not directly affect other aspects of living with epilepsy.
The effects of a brief memory enhancement course on individuals with epilepsy.Bautista, RED., Smith, L., Smith, FL., et al.[2021]
The HOBSCOTCH program, a self-management intervention for adults with epilepsy, significantly improved quality of life and cognitive performance, particularly in attention, over an 8-week period compared to a waitlisted control group of 66 participants.
While the intervention showed benefits in quality of life and cognitive function, it did not result in significant changes in depression scores, indicating that while cognitive issues can be addressed, mood-related challenges may require different approaches.
A cognitive behavioral intervention (HOBSCOTCH) improves quality of life and attention in epilepsy.Caller, TA., Ferguson, RJ., Roth, RM., et al.[2022]
Both healthy controls and left temporal lobe epilepsy (LTLE) patients showed improvements in verbal memory performance after participating in a memory rehabilitation program that included memory support strategies.
LTLE patients reported significant improvements in their subjective memory ratings, particularly linked to mood enhancements, but pre-operative rehabilitation did not lead to better outcomes compared to post-operative interventions.
Memory rehabilitation and brain training for surgical temporal lobe epilepsy patients: a preliminary report.Koorenhof, L., Baxendale, S., Smith, N., et al.[2014]

References

The effects of a brief memory enhancement course on individuals with epilepsy. [2021]
A cognitive behavioral intervention (HOBSCOTCH) improves quality of life and attention in epilepsy. [2022]
Memory rehabilitation and brain training for surgical temporal lobe epilepsy patients: a preliminary report. [2014]
A time-limited residential unit for young adults with epilepsy and mild cognitive impairment: results of a prospective pre-post-study. [2015]
Rehabilitation of cognition and psychosocial well-being - a better life with epilepsy (ReCaP-ABLE): a protocol for a randomized waitlist-controlled trial. [2023]
Supporting Attention in Children with Epilepsy (SPACE): Pilot of a psychoeducational intervention. [2023]
Evaluation of a self-regulation based psycho-educational pilot intervention targeting children and adolescents with epilepsy in Greece. [2018]
Subjective cognition is linked to everyday functioning in epilepsy. [2023]
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