Medication Adherence Plan for Kidney Transplant Rejection
Trial Summary
What is the purpose of this trial?
Non-adherence with immunosuppressant drugs is a major reason for premature kidney transplant failure. Currently, patient education and compliance aids (e.g bubble packing) are commonly used to assist patients. This is a study involving patients expected to undergo a kidney transplant within 6 months. One group will undergo a one-month formal assessment of adherence before transplantation using mock immunosuppressant medication. Standardized surveys will also be administered to assess risk factors for non-adherence. A plan will be developed for use after the transplant. The other group will undergo usual care. Kidney function and rejection rates will be compared between two groups.
Research Team
Marianna Leung, Pharm D
Principal Investigator
St. Paul's Hospital
Eligibility Criteria
This trial is for kidney transplant candidates expected to receive a new organ within the next 6 months. It's designed to help those who might struggle with taking their medication regularly, which is crucial for the success of the transplant.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-transplant Assessment
Interventional group undergoes a 1-month adherence trial with mock immunosuppressant medication and various assessments including health literacy, cognition, and self-efficacy.
Post-transplant Monitoring
Both groups receive tacrolimus capsules in MEMS caps for 3 months to measure adherence. Patients complete BAASIS and self-efficacy questionnaires.
Follow-up
Participants are monitored for kidney function, rejection rates, and adherence over a longer term.
Treatment Details
Interventions
- Tailored medication adherence plan
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor