Study Summary
This trial will evaluate the effectiveness of different interventions targeting visual functions that are often impaired in people with schizophrenia. The study will compare the effects of the interventions to a control condition of higher-level cognitive remediation. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.
Eligible Conditions
- Schizophrenia
- Schizoaffective Disorder
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 4 Secondary · Reporting Duration: Years 3-5
Years 1-5
Contour integration
Contrast sensitivity - behavioral
Contrast sensitivity - electrophysiological
Years 3-5
Cognition
Community functioning
Emotion recognition
Reading speed
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
Cognitive remediation
1 of 4
Contrast sensitivity + Perceptual org.
1 of 4
Contrast sensitivity
1 of 4
Perceptual organization
1 of 4
Active Control
Experimental Treatment
180 Total Participants · 4 Treatment Groups
Primary Treatment: UltimEyes + Contour Integration Training · No Placebo Group · N/A
Contrast sensitivity + Perceptual org.
Behavioral
Experimental Group · 1 Intervention: UltimEyes + Contour Integration Training · Intervention Types: BehavioralContrast sensitivity
Behavioral
Experimental Group · 1 Intervention: UltimEyes · Intervention Types: BehavioralPerceptual organization
Behavioral
Experimental Group · 1 Intervention: Contour Integration Training · Intervention Types: BehavioralCognitive remediation
Behavioral
ActiveComparator Group · 1 Intervention: MyBrainSolutions · Intervention Types: BehavioralTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: years 3-5
Who is running the clinical trial?
New York UniversityOTHER
205 Previous Clinical Trials
313,584 Total Patients Enrolled
University of RochesterLead Sponsor
791 Previous Clinical Trials
501,569 Total Patients Enrolled
1 Trials studying Schizophrenia
180 Patients Enrolled for Schizophrenia
Eligibility Criteria
Age 18 - 60 · All Participants · 6 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You must speak English.\n
You are able to complete the MCCB at the baseline assessment.
References
- “Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia”. 2020. “Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia”. Journal of Psychiatry and Brain Science. Hapres. doi:10.20900/jpbs.20200017.
- Butler, Pamela D., Judy L. Thompson, Aaron R. Seitz, Jenni Deveau, and Steven M. Silverstein. 2017. “Visual Perceptual Remediation for Individuals with Schizophrenia: Rationale, Method, and Three Case Studies.”. Psychiatric Rehabilitation Journal. American Psychological Association (APA). doi:10.1037/prj0000212.
- Silverstein SM, Seitz AR, Ahmed AO, Thompson JL, Zemon V, Gara M, Butler PD. Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia. J Psychiatr Brain Sci. 2020;5:e200017. doi: 10.20900/jpbs.20200017. Epub 2020 Jul 20.
- Steven Silverstein 2018. "Remediation of Visual Perceptual Impairments in Schizophrenia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03314129.
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Conditions
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Treatments