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Visual Perceptual Remediation for Schizophrenia (VRiS Trial)

N/A

Recruiting

Led By Steven M Silverstein, Ph.D.

Research Sponsored by University of Rochester

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

SCID-5 diagnosis of schizophrenia

Aged 18-60

Timeline

Screening 3 weeks

Treatment Varies

Follow Up years 3-5

Awards & highlights

VRiS Trial Summary

This trial will evaluate the effectiveness of different interventions targeting visual functions that are often impaired in people with schizophrenia. The study will compare the effects of the interventions to a control condition of higher-level cognitive remediation. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.

Who is the study for?

This trial is for individuals aged 18-60 with a diagnosis of schizophrenia, who speak English and can complete basic cognitive tests. They should be clinically stable with no recent medication changes and have at least a 6th-grade reading level. People with eye diseases, recent substance abuse, intellectual disabilities, or significant brain trauma are not eligible.Check my eligibility

What is being tested?

The study evaluates the effectiveness of visual remediation interventions for schizophrenia patients. It examines contrast sensitivity and perceptual organization through UltimEyes + Contour Integration Training versus each method alone or MyBrainSolutions as control. The best approach from phase one will undergo further testing in phase two.See study design

What are the potential side effects?

While specific side effects are not detailed for these non-pharmaceutical interventions, participants may experience fatigue or discomfort from focusing on visual tasks during the training sessions.

VRiS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with schizophrenia.

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I am between 18 and 60 years old.

VRiS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ years 3-5

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~years 3-5

This trial's timeline: 3 weeks for screening, Varies for treatment, and years 3-5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Contour integration

Contrast sensitivity - behavioral

Contrast sensitivity - electrophysiological

Secondary outcome measures

Cognition

Community functioning

Emotion recognition

+1 more

VRiS Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Perceptual organizationExperimental Treatment1 Intervention

Contour Integration Training

Group II: Contrast sensitivity + Perceptual org.Experimental Treatment1 Intervention

UltimEyes + Contour Integration Training

Group III: Contrast sensitivityExperimental Treatment1 Intervention

UltimEyes

Group IV: Cognitive remediationActive Control1 Intervention

MyBrainSolutions

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH

2,785 Previous Clinical Trials

2,689,576 Total Patients Enrolled

248 Trials studying Schizophrenia

89,244 Patients Enrolled for Schizophrenia

University of RochesterLead Sponsor

838 Previous Clinical Trials

518,387 Total Patients Enrolled

1 Trials studying Schizophrenia

180 Patients Enrolled for Schizophrenia

Weill Medical College of Cornell UniversityOTHER

1,054 Previous Clinical Trials

1,316,129 Total Patients Enrolled

7 Trials studying Schizophrenia

271 Patients Enrolled for Schizophrenia

Media Library

Contour Integration Training Clinical Trial Eligibility Overview. Trial Name: NCT03314129 — N/A

Schizophrenia Research Study Groups: Contrast sensitivity + Perceptual org., Contrast sensitivity, Perceptual organization, Cognitive remediation

Schizophrenia Clinical Trial 2023: Contour Integration Training Highlights & Side Effects. Trial Name: NCT03314129 — N/A

Contour Integration Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT03314129 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this investigation have any age limitations for prospective participants?

"To be eligible for this trial, participants must be aged 18 years or older and under 60."

Answered by AI

Are participants still being sought for this research project?

"According to records on clinicaltrials.gov, this study is still recruiting patients for participation. It was initially posted on June 1st 2018 and the most recent update occurred May 7th 2022."

Answered by AI

What are the primary goals of this research endeavor?

"Over the course of 5 years, researchers aim to evaluate progress in regards to cognitive integration. Secondary objectives include assessing residential and community functioning with the UCSD Performance-Based Skills Assessment (UPSA), measuring reading speed via Minnesota Low-Vision Reading Test (MNREAD) charts with sentences ranging from 1.3 to -0.5 logMAR at 16 inches away, as well as determining emotion recognition score through Penn Emotion Recognition Test results."

Answered by AI

Am I qualified to be a participant in this trial?

"In order to be accepted for this trial, applicants must suffer from schizophrenia and be between 18-60 years old. 180 patients are required in total."

Answered by AI

What is the upper limit for recruitment for this investigation?

"Affirmative, the clinicaltrials.gov entry for this experiment confirms that it is currently seeking participants. This research endeavour first went on record June 1st 2018 and was most recently altered May 7th 2022. Altogether, 180 patients are expected to be enrolled from one location."

Answered by AI

Recent research and studies

Journal of Psychiatry and Brain ScienceJournal

Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia

“Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia”. 2020. “Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia”. Journal of Psychiatry and Brain Science. Hapres. doi:10.20900/jpbs.20200017.

Psychiatric Rehabilitation JournalJournal

Visual Perceptual Remediation for Individuals with Schizophrenia: Rationale, Method, and Three Case Studies.

Butler, Pamela D., Judy L. Thompson, Aaron R. Seitz, Jenni Deveau, and Steven M. Silverstein. 2017. “Visual Perceptual Remediation for Individuals with Schizophrenia: Rationale, Method, and Three Case Studies.”. Psychiatric Rehabilitation Journal. American Psychological Association (APA). doi:10.1037/prj0000212.

clinicaltrials.govStudy

Remediation of Visual Perceptual Impairments in People With Schizophrenia

Steven Silverstein 2018. "Remediation of Visual Perceptual Impairments in People With Schizophrenia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03314129.

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