Inhibitory Control Training for Healthy Aging
What You Need to Know Before You Apply
What is the purpose of this trial?
In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory/postural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is inhibitory control training safe for humans?
How does inhibitory control training differ from other treatments for healthy aging?
Inhibitory control training is unique because it focuses on enhancing the brain's ability to suppress unwanted thoughts or actions, which is crucial for maintaining cognitive function as we age. Unlike other treatments, it specifically targets the brain's activity and connectivity within networks responsible for inhibition, adapting to age-related changes to improve cognitive control.36789
What data supports the effectiveness of the treatment Inhibitory Control Training for Healthy Aging?
Research shows that cognitive training targeting inhibitory control can improve cognitive functions in older adults, as seen in studies where such training enhanced memory and cognitive control. Additionally, multicomponent cognitive control training has been shown to increase brain activation and improve cognitive performance in older adults.4691011
Who Is on the Research Team?
Fang Jiang, Ph.D
Principal Investigator
University of Nevada, Reno
Are You a Good Fit for This Trial?
This trial is for older adults aged between 65 and 80, as well as a younger group aged between 20 and 35. Participants must not have serious vision or uncorrected hearing problems, early dementia, cognitive impairments, epilepsy, stroke, Parkinson's disease, Alzheimer's disease, ADHD or history of significant head injury.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-training Assessment
Assessment of multisensory temporal processing abilities, postural stability, gait performance, brain GABA concentration, and resting-state network segregation
Training
Participants undergo 20 days of either inhibitory control training or knowledge-based training
Post-training Assessment
Re-assessment of multisensory temporal processing abilities, postural stability, gait performance, brain GABA concentration, and resting-state network segregation
Follow-up
Participants are monitored for the persistence of training effects on multisensory temporal processing and postural control
What Are the Treatments Tested in This Trial?
Interventions
- Active training
- Inhibitory control training
- Knowledge-based training
- Passive training
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Nevada, Reno
Lead Sponsor