Training visual sensitivity for Macular Degeneration

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UAB, Birmingham, AL
Macular Degeneration+3 More
Training visual sensitivity - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging population are consistent with the mission of the NIA.

Eligible Conditions

  • Macular Degeneration
  • Central Visual Impairment

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Macular Degeneration

Study Objectives

3 Primary · 0 Secondary · Reporting Duration: Baseline and Within 3 weeks of training completion, training is complete 7 weeks from baseline on average

Week 7
Change from Baseline Acuity after Completion of Training at approximately 7 weeks
Change from Baseline Completion time in the trail making task after Completion of Training at approximately 7 weeks
Change from Baseline Contrast Sensitivity after Completion of Training at approximately 7 weeks
Change from Baseline Cortical thickness in V1, V2 and V3 representations of the PRL and URL after Completion of Training at approximately 7 weeks
Change from Baseline Crowding Threshold after Completion of Training at approximately 7 weeks
Change from Baseline Decoding classification accuracy for an attended character after Completion of Training at approximately 7 weeks
Change from Baseline Decoding classification accuracy for decoding the locus of spatial attention (PRL or URL), regardless of stimulus type after Completion of Training at approximately 7 weeks
Change from Baseline Endogenous Attention after Completion of Training at approximately 7 weeks
Change from Baseline Exogenous Attention after Completion of Training at approximately 7 weeks
Change from Baseline Fixation Stability after Completion of Training at approximately 7 weeks
Change from Baseline Minimal print size from the MNREAD task after Completion of Training at approximately 7 weeks
Change from Baseline Orientation jitter threshold in the contour integration task at PRL or URL after Completion of Training at approximately 7 weeks
Change from Baseline Population receptive field size in V1, V2 and V3 representations of URL and PRL after Completion of Training at approximately 7 weeks
Change from Baseline Precision of Reconstructed Representation of Stimulus Orientation after Completion of Training at approximately 7 weeks
Change from Baseline Radial Bias from the Crowding Task after completion of Training at approximately 7 weeks
Change from Baseline Reading speed in the MNREAD task after Completion of Training at approximately 7 weeks
Change from Baseline Saccadic Precision after Completion of Training at approximately 7 weeks
Change from Baseline Saccadic Re-referencing after Completion of Training at approximately 7 weeks
Change from Baseline Strength of background connectivity between areas with larger receptive fields (V4) to the smaller receptive fields contributing information to that area. after Completion of Training at approximately 7 weeks
Change from Baseline Sustained Attention after Completion of Training at approximately 7 weeks
Change from Baseline Top-down modulation of visual areas after Completion of Training at approximately 7 weeks

Trial Safety

Safety Progress

1 of 3

Other trials for Macular Degeneration

Trial Design

2 Treatment Groups

Combination training
1 of 2
Training visual sensitivity
1 of 2
Experimental Treatment

60 Total Participants · 2 Treatment Groups

Primary Treatment: Training visual sensitivity · No Placebo Group · N/A

Combination training
Behavioral
Experimental Group · 1 Intervention: Combination training · Intervention Types: Behavioral
Training visual sensitivity
Behavioral
Experimental Group · 1 Intervention: Training visual sensitivity · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and within 3 weeks of training completion, training is complete 7 weeks from baseline on average

Trial Background

Prof. Kristina M Visscher, Associate Professor
Principal Investigator
University of Alabama at Birmingham
Closest Location: UAB · Birmingham, AL
Photo of Birmingham  1Photo of Birmingham  2Photo of Birmingham  3
2011First Recorded Clinical Trial
3 TrialsResearching Macular Degeneration
28 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are aged 18-89.
You have a visual acuity of 20/100 or worse in both eyes.
The patient has a light sensitivity in the macular region of the retina that is at least 10 dB units worse than in peripheral regions.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.