HD-EEG for Nervous System Disorders

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Dartmouth-Hitchcock Medical Center

Disqualifiers: Stroke, Tumor, Psychosis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

100 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It might be best to ask the trial organizers for more details.

What data supports the effectiveness of the treatment High-density electroencephalogram (HD-EEG) for nervous system disorders?

Research shows that HD-EEG is effective in improving the localization of seizure onset zones in epilepsy, which helps in better clinical management. This suggests that HD-EEG can provide valuable information for treating nervous system disorders by offering more precise brain activity mapping. ^{1 2 3 4 5}

Is HD-EEG safe for use in humans?

HD-EEG has been used safely in clinical settings for epilepsy and sleep research, with no specific safety concerns reported in the available studies. ^{2 3 4 5 6}

How does HD-EEG treatment differ from other treatments for nervous system disorders?

HD-EEG (high-density electroencephalography) is unique because it uses a higher number of electrodes to provide detailed brain activity maps, which can improve the localization of brain abnormalities compared to standard EEG. This enhanced spatial resolution can be particularly useful in diagnosing and managing conditions like epilepsy, where precise localization of the affected brain areas is crucial. ^{3 4 5 6 7}

What is the purpose of this trial?

The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.

Eligibility Criteria

This trial is for individuals who can perform specific tasks and give consent on their own. It's suitable for those with epilepsy, healthy subjects, or other nervous system disorders. People with conditions like stroke, tumors, or psychosis that could affect EEG results cannot participate.

Inclusion Criteria

Able to give own consent

I can do the tasks required in the study.

Exclusion Criteria

I do not have any brain conditions like stroke or psychosis that could affect EEG tests.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

High-density EEG recordings are conducted to localize brain functions in patients and healthy controls

1-2 weeks

1 visit (in-person)

Follow-up

Participants are monitored for any immediate effects or reactions post-EEG recording

1 week

Treatment Details

Interventions

• High-density electroencephalogram (HD-EEG)

Trial Overview The study is testing a new method called high-density electroencephalogram (HD-EEG) to map brain functions related to movement, sensation, language, emotion, and thinking in people with neurological conditions.

Participant Groups

Group I: High-density EEG localization in tumor patients Experimental Treatment 1 Intervention

High-density EEG will be used for brain localization in tumor patients

Group II: High-density EEG localization in stroke patients Experimental Treatment 1 Intervention

High-density EEG will be used for brain localization in patients who have recently experienced a stroke

Group III: High-density EEG localization in peripheral nerve patients Experimental Treatment 1 Intervention

High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction

Group IV: High-density EEG localization in epilepsy Experimental Treatment 1 Intervention

High-density EEG will be used for brain localization in epilepsy patients

Group V: High-density EEG localization in healthy controls Active Control 1 Intervention

High-density EEG will be used for brain localization in healthy controls

Who Is Running the Clinical Trial?

Dartmouth-Hitchcock Medical Center

Lead Sponsor

Trials

548

Recruited

2,545,000+

References

1. Netherlands pubmed.ncbi.nlm.nih.gov

Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy. [2023]

2. United States pubmed.ncbi.nlm.nih.gov

High-Density Adaptive Ten Ten: Proposal for Electrode Nomenclature for High-Density EEG. [2021]

3. Netherlands pubmed.ncbi.nlm.nih.gov

'High-Density-SleepCleaner': An open-source, semi-automatic artifact removal routine tailored to high-density sleep EEG. [2023]

4. Italy pubmed.ncbi.nlm.nih.gov

Use, experience and perspectives of high-density EEG among Italian epilepsy centers: a national survey. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

High-Density EEG in Current Clinical Practice and Opportunities for the Future. [2023]

6. England pubmed.ncbi.nlm.nih.gov

EEG may serve as a biomarker in Huntington's disease using machine learning automatic classification. [2019]

7. Switzerland pubmed.ncbi.nlm.nih.gov

High density electroencephalography in sleep research: potential, problems, future perspective. [2021]