Motor procedural memory task plus auditory stimulation for Aura
This study is evaluating whether a specific type of noise can help improve memory for individuals with epilepsy.
See full descriptionAbout the trial for Aura
Treatment Groups
This trial involves 2 different treatments. Motor Procedural Memory Task Plus Auditory Stimulation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex of any age. There are 5 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Motor procedural memory task plus auditory stimulation will improve 1 primary outcome and 4 secondary outcomes in patients with Aura. Measurement will happen over the course of Three nights of sleep within three weeks.
Who is running the study
Principal InvestigatorPatient Q & A Section
How many people get aura a year in the United States?
There are differences among the states as to the rates and characteristics of aura episodes. Consideration of the patient's ethnicity and state of residence will help physicians to better identify patients who will most often experience aura.
What are the signs of aura?
Individuals with aura report headache, nausea, vomiting, dyspnea, dysuria, aphasia, loss of consciousness, and other symptoms of stroke. Most subjects with aura continue to have seizures after a stroke.
What are common treatments for aura?
The most common treatment for auras is beta-blockers, with oral or injected, though some also received parenteral injections of thiothixene or phenelzine. There appears to be poor adherence and compliance rates to beta-blocker therapy. More research is needed to determine how to best implement and strengthen thiothixene and phenelzine therapy in patients with auras.
Can aura be cured?
The authors conclude that the evidence that aura can be cured at this time is weak. It is possible that when remission is obtained, some long-term remissions are missed because patients cease to perceive auras before they are totally gone. No other disorder has thus far been shown to be fully curable. Further follow-up may yield better-than-expected outcomes.
What is aura?
In a variety of different circumstances, including some of the most common types of headache, a spectrum of sensations may be experienced that have no known physical or organic causes. These sensations can include the feeling of a ringing in the ears, tingling, electric or other sensation around the mouth, and fluttering sensation in the arms and abdomen. The sensations are typically localized and the pain threshold is generally reduced but can sometimes be painful. Different types of auras appear to have distinct pathophysiology and prognosis. What is aura? answer: The study results show that auras were not rare in children and adolescents and that there are auras in a wide variety of circumstances.
What causes aura?
Results from a recent clinical trial suggest that the most common cause of aura is subarachnoid hemorrhage, and seizure or migraine may occur as a secondary manifestation of the SAH, a possible explanation of aura in other subarachnoid hemorrhages, or that a subarachnoid hemorrhage occurs as a cause of seizure or migraine. There have also been reports of migraines as a consequence of subarachnoid hemorrhage, but the exact mechanism by which an initial subarachnoid hemorrhage triggers a headache remains unknown.
Does aura run in families?
There is evidence that there are predispositions for migraine aura within families, but the relationship is weak. Migraine auras and migraineurs in other families are less strongly associated.
Who should consider clinical trials for aura?
[As well as, ]patient should be counseled about the [potential risks of a trial, should be invited to attend study selection visits, should be asked about [pre-existing conditions, and should be asked if he is willing to undertake follow-up visits to monitor outcomes like, recurrence of aura] for both a short-term assessment and long-term monitoring to determine whether treatments actually have any effect on outcome [sic] for such patients.
What are the latest developments in motor procedural memory task plus auditory stimulation for therapeutic use?
A novel neurobehavioral deficit (incremental auditory feedback errors during a serial tapping task) in an older healthy human subject was demonstrated for the first time. This deficit could be used as a candidate biomarker to identify early stage subjects at higher risk for future cognitive decline. (www.clinicaltrials.gov; NCT 00643921.
Have there been other clinical trials involving motor procedural memory task plus auditory stimulation?
It was concluded that both NMST and NMST+SS may be effective in the therapy of declarative memory disorders in a variety of clinical trials. The findings showed that the combined method, the NMST+SS, may be more effective than NMST only in the treatment of anterograde amnesia.
Is motor procedural memory task plus auditory stimulation safe for people?
Results from a recent clinical trial demonstrates the feasibility of using an auditory stimulation as a tool to reduce the frequency with which procedural memory tasks may have to be repeated. The present results are in line with previous findings showing that auditory stimulation can benefit procedural learning and that this effect is greater over multiple trials than over a single event-encoding session, and that auditory stimulation can reduce the frequency with which procedural-memory tasks must be repeated. Based on the present results, auditory stimulation of procedural memory tasks may become a tool in rehabilitation.
How does motor procedural memory task plus auditory stimulation work?
Auditory stimulation in motor cognition intervention is effective in enhancing PPI, but it is found that auditory stimulation alone does not elicit procedural motor improvement. Therefore, the enhancement may be attributed to procedural memory, memory-based attention, and the interaction effect of both processing the motor learning task and listening to music through the task.