← Back to Search

Auditory Stimulation for Epilepsy

N/A

Recruiting

Led By Dara Manoach, PhD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Aged 12-65

Inpatients with epilepsy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up three nights of sleep within three weeks

Awards & highlights

Study Summary

This trial will study whether playing noise at specific times can improve memory in epilepsy patients with implanted hippocampal electrodes.

Who is the study for?

This trial is for English-speaking epilepsy patients aged 12-65 who are inpatients with implanted hippocampal electrodes and can consent to the study. It's not suitable for those with intellectual disabilities affecting task performance, anticipated surgery that could affect sleep oscillations, or motor issues preventing finger tapping tasks.Check my eligibility

What is being tested?

The study tests if brief bursts of noise during sleep can enhance brain rhythms and improve memory in epilepsy patients. Participants will perform a motor procedural memory task with and without auditory stimulation while undergoing EEG monitoring.See study design

What are the potential side effects?

Since this trial involves non-invasive auditory stimulation and standard memory tasks, side effects may be minimal but could include discomfort from the noise or fatigue from performing the memory tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 12 and 65 years old.

Select...

I am hospitalized due to epilepsy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ three nights of sleep within three weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~three nights of sleep within three weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and three nights of sleep within three weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in slow oscillation-spindle-hippocampal ripple coupling

Secondary outcome measures

Changes in hippocampal ripples

Changes in sleep spindles

Changes in sleep-dependent consolidation of motor procedural memory

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Epilepsy inpatientsExperimental Treatment3 Interventions

Epilepsy inpatients with implanted hippocampal electrodes and continuous scalp EEG monitoring

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,933 Previous Clinical Trials

13,198,431 Total Patients Enrolled

8 Trials studying Epilepsy

588 Patients Enrolled for Epilepsy

Dara Manoach, PhDPrincipal InvestigatorProfessor

2 Previous Clinical Trials

100 Total Patients Enrolled

Media Library

Motor procedural memory task plus auditory stimulation Clinical Trial Eligibility Overview. Trial Name: NCT04788628 — N/A

Epilepsy Research Study Groups: Epilepsy inpatients

Epilepsy Clinical Trial 2023: Motor procedural memory task plus auditory stimulation Highlights & Side Effects. Trial Name: NCT04788628 — N/A

Motor procedural memory task plus auditory stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04788628 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any remaining openings for individuals to participate in this experiment?

"Affirmative. The clinical trial is currently recruiting, as attested to by the information available on clinicaltrials.gov. This research endeavour was first posted on January 1st 2021 and most recently updated in December 13th 2021; 20 participants are needed from a single medical centre."

Answered by AI

How many participants are allowed to join this medical investigation?

"That is indeed the case. According to information on clinicaltrials.gov, this medical trial was posted in January 1st 2021 and its most recent update occurred December 13th 2021. The experiment needs 20 patients from a single location to take part."

Answered by AI

What type of participants is best suited for this trial?

"This trial is accepting 20 participants aged between 12 and 65 who are currently experiencing aura. Moreover, potential patients must also fit the criteria of being inpatients with epilepsy."

Answered by AI