Virtual Rehab Cycling for Parkinson's Disease
(PDBIKE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease. The investigators will examine the efficacy of novel rehab technique that can be monitored and modified in real-time but over virtual interface using a remotely located device in a paradigm called dynamic cycling. This technology will benefit thousands of Veterans who need customized and cost-effective rehab but cannot travel to specialized facilities due to inevitable limitations such as pandemics or because of lack of resources, social support, frailty, or home-bound status.
Will I have to stop taking my current medications?
The trial requires that participants have a stable medical regimen of antiparkinsonian medication for at least six months, so you will not need to stop taking your current medications if they are stable.
Is virtual rehab cycling safe for humans?
Research on functional electrical stimulation (FES) cycling, which is similar to virtual rehab cycling, shows it is generally safe for humans. Studies involving people with conditions like multiple sclerosis and spinal cord injury have not reported significant safety concerns, suggesting it is a safe exercise option.12345
How is the Virtual Rehab Cycling treatment for Parkinson's disease different from other treatments?
Virtual Rehab Cycling is unique because it uses high-cadence cycling, which involves pedaling at a fast pace, to improve motor symptoms in Parkinson's disease. This approach is different from traditional treatments as it combines physical exercise with virtual environments and cueing strategies to enhance engagement and effectiveness.678910
What data supports the effectiveness of the treatment Virtual Rehab Cycling for Parkinson's Disease?
Research shows that high-cadence cycling, including forced and active-assisted cycling, can improve motor symptoms like tremor and bradykinesia (slowness of movement) in people with Parkinson's disease. Additionally, virtual environments with auditory and visual cues can enhance exercise intensity and engagement, potentially benefiting motor function.678910
Who Is on the Research Team?
Aasef G. Shaikh, MD PhD
Principal Investigator
Louis Stokes VA Medical Center, Cleveland, OH
Are You a Good Fit for This Trial?
This trial is for individuals with Parkinson's Disease who can consent, have been on stable Parkinson's medication for at least six months, and are in stages I-III of the disease without medication. It excludes those with severe cognitive impairment, depression or anxiety disorders, certain other neurological conditions, untreated cardiovascular issues, or significant fatigue or breathlessness during mild activity.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in dynamic cycling exercise regimen, monitored and adjusted remotely, for 4 weeks
Follow-up
Participants are monitored for changes in motor function, balance, and cognitive outcomes at 0, 3, and 6 months after the intervention
What Are the Treatments Tested in This Trial?
Interventions
- Dynamic cycling
- Forced cycling
Dynamic cycling is already approved in United States for the following indications:
- Parkinson's disease rehabilitation
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor