Dynamic high-cadence cycling for Parkinson Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Kent State University, Kent, OH
Parkinson Disease
Dynamic high-cadence cycling - Behavioral
Eligibility
18+
All Sexes
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Study Summary

Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability. These symptoms significantly affect PD patients' quality of life, independence, and functional performance. There is currently no cure for PD, but symptoms can be treated with levodopa or deep brain stimulation surgery. Exercise-based rehabilitation has similar beneficial effects to surgical and pharmacological management without the potential negative side effects. Cycling-based interventions have been shown to increases motor function and mobility in individuals with PD. Specifically, benefits are greater when cycling cadence (revolutions per minute, RPM) is 30% greater than a self-selected pace. Although high cadence cycling improves motor function in individuals with PD, there is significant heterogeneity in individual responses. To maximize the treatment effects and minimize the heterogeneity of high-cadence cycling, it is important to determine patient-specific settings. Previous studies have shown that higher variability (entropy) of cadence leads to greater improvement in motor function. The entropy of cadence calculation will be utilized to understand how patient-specific settings can drive improvements. The purpose of this study is to determine patient-specific settings and measure the effects of high cadence stationary (i.e. dynamic) cycling on functional performance in individuals with PD. Volunteers with Parkinson's disease will complete 12 cycling sessions over a 1-month period and measures of motor function, quality of life, functional performance, mood and exercise readiness will be collected.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: 4 weeks

4 weeks
Change in mobility
Change in mood and affect
Change in motor kinematics
Change in motor symptoms
Change in quality of life

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Non-adaptive dynamic cycling
1 of 2
Adaptive dynamic cycling
1 of 2
Active Control
Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Dynamic high-cadence cycling · No Placebo Group · N/A

Adaptive dynamic cycling
Behavioral
Experimental Group · 1 Intervention: Dynamic high-cadence cycling · Intervention Types: Behavioral
Non-adaptive dynamic cycling
Behavioral
ActiveComparator Group · 1 Intervention: Dynamic high-cadence cycling · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 4 weeks

Trial Background

Prof. Angela Ridgel, Professor, School of Health Sciences
Principal Investigator
Kent State University
Closest Location: Kent State University · Kent, OH
2014First Recorded Clinical Trial
2 TrialsResearching Parkinson Disease
7 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.