← Back to Search

Behavioural Intervention

Exercise + Ketone Supplement for Parkinson's Disease (CYCLE Trial)

N/A

Recruiting

Led By Chatkaew Pongmala, PhD

Research Sponsored by University of Michigan

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after approximately 2-weeks of intervention

Awards & highlights

CYCLE Trial Summary

This trial tests how an exercise program plus a ketone supplement can improve exercise capacity in people with Parkinson's disease.

Who is the study for?

This trial is for individuals with Parkinson's Disease who can safely perform exercises like cycling. It's not suitable for those with recent heart issues, uncontrolled diabetes, pregnancy, severe dementia, or conditions that make exercise unsafe such as significant pain or active rheumatoid arthritis.Check my eligibility

What is being tested?

The study aims to see if a ketone ester beverage improves muscle strength and cardiovascular response when combined with an exercise program (cycling) in people with Parkinson's compared to just exercising while taking an electrolyte beverage.See study design

What are the potential side effects?

Potential side effects may include digestive discomfort from the ketone ester beverage. Exercise might cause fatigue or muscle soreness. Specific side effects will depend on individual health conditions.

CYCLE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after approximately 2-weeks of intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after approximately 2-weeks of intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and after approximately 2-weeks of intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in duration of 80 rpm endurance test

Change in isometric quadricep muscle strength

Change in oxygen uptake (VO2 max)

CYCLE Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Ketone Ester Beverage & ExerciseExperimental Treatment2 Interventions

Participants will consume ketone ester (KE) beverage, consisting of 2 scoops (=25 g C8-KE) of Juvenescence Cognitive Switch ™ and electrolyte solution diluted in water, before each of 5 1-hour sessions of aerobic exercise.

Group II: Electrolyte Beverage & ExercisePlacebo Group2 Interventions

Participants will consume placebo electrolyte (EL) beverage, consisting of an electrolyte solution diluted in water, before each of 5 1-hour sessions of aerobic exercise

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor

1,798 Previous Clinical Trials

6,378,122 Total Patients Enrolled

Chatkaew Pongmala, PhDPrincipal InvestigatorUniversity of Michigan

1 Previous Clinical Trials

40 Total Patients Enrolled

Media Library

Cycling Intervention (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05948956 — N/A

Parkinson's Disease Research Study Groups: Ketone Ester Beverage & Exercise, Electrolyte Beverage & Exercise

Parkinson's Disease Clinical Trial 2023: Cycling Intervention Highlights & Side Effects. Trial Name: NCT05948956 — N/A

Cycling Intervention (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05948956 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research project currently open to recruitment?

"According to clinicaltrials.gov, this ongoing trial is actively recruiting suitable participants. It was first advertised on July 28th of 2023 and its details were most recently revised the same day."

Answered by AI

How many participants are being accepted into this research endeavor?

"Confirmed. Clinicaltrials.gov verifies that this experiment, first uploaded on July 28th 2023, is actively searching for test subjects. The team seeks 16 participants from a single recruitment site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in Parkinson's Disease

Chatkaew Pongmala 2023. "Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in Parkinson's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05948956.